DEM-DDM Investigation of the Tablet Coating Process Using Different Particle Shape Models

Liu, Zihan; Ma, Huaqing; Zhou, Lianyong; Liu, Yanlei; Huang, Ze; Liao, Xiaoling; Zhao, Yongzhi

doi:10.1021/acs.iecr.2c04030

Cited by 7 publications

(2 citation statements)

References 58 publications

(110 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The DEM is an effective method to solve and analyze the motion of dense particles in the rotating drum . The soft sphere model is used to deal with the collision between particles, and the Hertz–Mindlin (no slip) model is used to calculate the particle contact force. , The effect of gas on particles in the rotating drum is ignored . Newton’s second law of motion is used to describe the translation and rotation of particles in the Lagrangian system.…”

Section: Methodsmentioning

confidence: 99%

Study on Segregation and Heat Transfer of Polydisperse Particles in a Three-Dimensional Rotating Drum by Using the DEM

Zhang

Liu

et al. 2023

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

The segregation and heat transfer of polydisperse particles in the rotating drum have an important impact on many industrial fields, and the theory is not completely clear. Based on the verified discrete element method model, the segregation and heat transfer of polydisperse particles in the rotating drum indirectly heated by the side wall are studied. The results show that the polydisperse particles form the segregation structure of the radial core and axial band in the rolling regime rotating drum. The comparison with monodisperse particles indicates that the heat transfer of polydisperse particles is influenced by the segregation structure. Small changes in rotation speed and filling level in the rolling regime do not alter the particle segregation and heat transfer structure. The addition of lifters is an effective means to reduce particle segregation and improve the heat transfer effect. This work provides a reference for revealing the segregation and heat transfer theory of polydisperse particles in the rotating drum.

show abstract

Section: Methodsmentioning

confidence: 99%

Study on Segregation and Heat Transfer of Polydisperse Particles in a Three-Dimensional Rotating Drum by Using the DEM

Zhang

Liu

et al. 2023

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

show abstract

“…The describes implementation works in-place, so whilst simulation runtime, properties (liquid content, particle mass, friction coefficients or cohesive forces) can change and alter the granular flow. Another approach to simulate spray is a kind of a droplet fog, shown in [6].…”

Section: Dem -Specialized For Pharmaceutical Processingmentioning

confidence: 99%

Oblong True Shape Tablets as an Industrial Scale Digital Twin

Radeke,

Wang,

Rabold

2023

Preprint

View full text Add to dashboard Cite

Tablets are the most used solid dosage form in medical treatments. The realistic modeling 1 of such specific object shapes in computer simulations has been demonstrated already by the author 2 for bi-convex round tablets but needs to be extended for a wider range of tablet shapes. Moreover, 3 the number of tablets must be large enough to simulate industrial drum coaters, which are typically 4 used for film coating processes. Whilst this long lasting process where tablets flow continuously, 5 tablets are loaded by frequent changes of individual contacts. Using a tailored simulation tool named 6 pharmAssist , written for GPUs (modern massively parallel processors in graphics cards and HPC 7 accelerators), we implemented the widely used oblong tablet shape. We are able to simulate flows 8 involving industrial scale number of such tablets. Data mining allows for statistical analyzis of 9 pair-wise contacts of different geometric features. Our simulation results serves as an observation 10 space, which cannot be addressed by experimental analyzis and will help to avoid degradation of 11 tablets like chipping or other defect phenomena. This paper reflects current development work in 12 order to extend the DEM with a new shape class, which comprises the modelling of compacted or 13 extruded objects, which have a smooth exterior, a flat band and sharp contour edges

show abstract

Understanding the correlations between tablet flow dynamics and coating uniformity in a pan coater: Experiments and simulations

Chen

Jin

et al. 2023

Chemical Engineering Journal

View full text Add to dashboard Cite

DEM-DDM Investigation of the Tablet Coating Process Using Different Particle Shape Models

Cited by 7 publications

References 58 publications

Study on Segregation and Heat Transfer of Polydisperse Particles in a Three-Dimensional Rotating Drum by Using the DEM

Study on Segregation and Heat Transfer of Polydisperse Particles in a Three-Dimensional Rotating Drum by Using the DEM

Oblong True Shape Tablets as an Industrial Scale Digital Twin

Understanding the correlations between tablet flow dynamics and coating uniformity in a pan coater: Experiments and simulations

Contact Info

Product

Resources

About