Delusions of Korean patients with Alzheimer's disease: Study of drug‐naïve patients

Kwak, Yong Tae; Yang, YoungSoon; Kwak, Soongu; Koo, Min-Seong

doi:10.1111/j.1447-0594.2012.00897.x

Cited by 15 publications

(13 citation statements)

References 32 publications

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“…In particular, home misidentification appears to be underestimated in previous studies, 10,12,16,19 whereas the Capgras syndrome (which seems far more frequent in DLB than in AD) was detected in similar percentages and consistently with our result. [10][11][12]16,17,20 Interestingly, even if Capgras syndrome is commonly referred to misidentification of people, our study found that Capgras for objects/animals is not so rare.…”

Section: Discussionmentioning

confidence: 52%

“…[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Even in DLB, where they are observed more frequently, the percentage varies considerably from 38% to 78.3%. 16 The variability of previous reports is probably accounted for by different types of included dementia, different severity of cognitive impairment, and above all different assessment definitions/methods for MD.…”

Section: Discussionmentioning

confidence: 99%

“…Data about the prevalence of these delusions in different types of dementia are so far available from a variety of different tools, from semistructured interviews to more general neuropsychiatric scales: maybe for this reason their reported prevalence is highly variable, ranging from 5.2% to 81.6% (Table 1). [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Moreover, often only limited syndromes are investigated. An extensive and structured selfadministered questionnaire specifically constructed on MD is not available till now.…”

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confidence: 99%

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Misidentification Delusions

Perini

Carlini

Pomati

et al. 2016

Alzheimer Disease &Amp; Associated Disorders

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Misidentification delusions (MDs) are considered relatively rare psychopathologic phenomena that may occur within the context of psychiatric or neurological conditions. The purpose of this study was to assess the prevalence of MD in different types of dementia, correlate the presence of MD with demographic and clinical variables, and validate a specific questionnaire. We examined 146 subjects with Alzheimer disease, 21 with Lewy body dementia, 6 with frontotemporal dementia, and 13 with vascular dementia (subcortical type), who were consecutively enrolled in the study from 2 Memory Clinics. Patients had a mean age of 78.7±6.4 years and an Mini-Mental State Examination average score of 16.9±6.1. The Neuropsychiatric Inventory delusion subscale and a new Misidentification Delusion Questionnaire aimed at specific assessment of 11 delusional misidentification syndromes were administrated to the caregivers. On the basis of the Neuropsychiatric Inventory, MDs were present in 33.3% of the subjects, whereas according to the Misidentification Delusion Questionnaire they were present in 36.0% of the subjects. Specifically, 34.2% of Alzheimer disease, 52.4% of Lewy body dementia, and 46.1% of vascular dementia patients experienced at least 1 MD. None of the patients with frontotemporal dementia developed MD. The most frequent MD was house misidentification, followed by splitting of people and reduplicative paramnesia. Our self-administered questionnaire proved to be an accurate and specific tool for the detection of MD.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Misidentification Delusions

Perini

Carlini

Pomati

et al. 2016

Alzheimer Disease &Amp; Associated Disorders

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“…One possible explanation is that delusion is closely related with agitation and aberrant motor behavior,12,13 and these physical symptoms apparently lead to problems in assessing these time-consuming tests. Moreover, patients with delusions frequently have persecutory delusion,14,15 and as a results some patients with this delusion may resist diagnostic evaluations.…”

Section: Discussionmentioning

confidence: 99%

Missing Data Analysis in Drug-Naïve Alzheimer's Disease with Behavioral and Psychological Symptoms

2013

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PurposeTo clarify the effects of missing values due to behavioral and psychological symptoms in dementia (BPSD) in Alzheimer's disease (AD) patients on the neuropsychological tests, this study describes the pattern of missing values due to BPSD, and its influence on tests.Materials and MethodsDrug-naïve probable AD patients (n=127) with BPSD and without BPSD (n=32) were assessed with Seoul Neuropsychological Screening Battery including measures of memory, intelligence, and executive functioning. Moreover, patients were rated on Korean Neuropsychiatry Inventory (K-NPI).ResultsThe more severe the K-NPI score, the less neuropsychological tests were assessable, leading to many missing values. Patients with BPSD were more severely demented than those without BPSD. K-NPI scores were significantly correlated with the number of missing values. The effect of BPSD was largest for tests measuring frontal functions. The replacement of the missing values due to BPSD by the lowest observed score also showed the largest effect on tests of frontal function.ConclusionThe global cognitive and behavior scales are related with missing values. Among K-NPI sub-domains, delusion, depressing, apathy, and aberrant motor behavior are significantly correlated for missing values. Data imputation of missing values due to BPSD provides a more differentiated picture of cognitive deficits in AD with BPSD.

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“…Persecutory delusions occur early during the progression of AD and associate with disruption of frontostriatal circuits [107]. One study found delusions in 27.4% of AD patients, with paranoid delusions being the most common (60.3%), followed by misidentification delusions (19.0%), and then mixed delusions (17.5%), the latter appearing later and associated with greater cognitive impairment [108]. Psychotic patients show greater A β 1-42 at autopsy [109].…”

Section: Psychosismentioning

confidence: 99%

Behavioral and Psychological Symptoms in Alzheimer’s Disease

Tan

et al. 2014

BioMed Research International

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Neuropsychiatric symptoms (NPS) such as depression, apathy, aggression, and psychosis are now recognized as core features of Alzheimer's disease (AD), and there is a general consensus that greater symptom severity is predictive of faster cognitive decline, loss of independence, and even shorter survival. Whether these symptoms result from the same pathogenic processes responsible for cognitive decline or have unique etiologies independent of AD-associated neurodegeneration is unclear. Many structural and metabolic features of the AD brain are associated with individual neuropsychiatric symptoms or symptom clusters. In addition, many genes have been identified and confirmed that are associated with symptom risk in a few cases. However, there are no single genes strongly predictive of individual neuropsychiatric syndromes, while functional and structural brain changes unique to specific symptoms may reflect variability in progression of the same pathological processes. Unfortunately, treatment success for these psychiatric symptoms may be lower when comorbid with AD, underscoring the importance of future research on their pathobiology and treatment. This review summarizes some of the most salient aspects of NPS pathogenesis.

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Delusions of Korean patients with Alzheimer's disease: Study of drug‐naïve patients

Abstract: This study showed that delusions are associated with global cognitive dysfunction. Although paranoid delusions are the most common, misidentification and mixed delusions comprised significant portions of delusions in AD patients, and appeared in the later stages of dementia.

Cited by 15 publications

References 32 publications

Misidentification Delusions

Misidentification Delusions

Missing Data Analysis in Drug-Naïve Alzheimer's Disease with Behavioral and Psychological Symptoms

Behavioral and Psychological Symptoms in Alzheimer’s Disease

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