Delusions in Patients with Dementia with Lewy Bodies and the Associated Factors

Tzeng, Ray Chang; Tsai, Ching Fang; Wang, Ching Tsu; Wang, Tzu Yuan; Chiu, Pai-Yi

doi:10.1155/2018/6707291

Cited by 12 publications

(13 citation statements)

References 36 publications

(53 reference statements)

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“…A cross-sectional and retrospective study of 1025 patients with dementia in Spain found that delusion and hallucinations were more prevalent in DLB patients than those with AD and PDD [ 23 ]. In a recent comparative study of 207 delusional and nondelusional patients with DLB, the authors concluded that the delusional patients had poorer cognitive function and more severe neuropsychiatric symptoms [ 24 ]. In a cross-sectional study, 21 DLB and 35 PDD patients with recurrent visual hallucinations were evaluated.…”

Section: Methodsmentioning

confidence: 99%

Quality of Life in Patients with Dementia with Lewy Bodies

Lee

Cheng

Lin

et al. 2018

Behavioural Neurology

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Dementia with Lewy bodies (DLB) is a complex, multisymptom disorder. When making decisions regarding the treatment of DLB, the patient's quality of life (QoL) should always be the main consideration. To our knowledge, this is the first review article focusing on the QoL in DLB patients. We searched the PubMed database using the keywords “quality of life” and “dementia with Lewy bodies.” Previously, no specific instrument had been developed for assessing the QoL in DLB patients. Patients with DLB have a decreased QoL compared to patients with Alzheimer's disease, which is reportedly caused by several factors including level of independence in instrumental activities of daily living, whether the patient is living with the caregiver, apathy, delusion, and dysautonomia. The direct effect of visual hallucination, sleep, and movement disorders on the QoL in DLB patients has not been previously studied. The role of cognitive function on the QoL is still controversial. In a randomized controlled study, memantine may improve the QoL in PDD or DLB patients. We concluded that it is important to develop a specific instrument to assess the QoL in DLB patients. Furthermore, there is an urgent need for large clinical trials to identify factors associated with the QoL and how they can be managed.

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Section: Methodsmentioning

confidence: 99%

Quality of Life in Patients with Dementia with Lewy Bodies

Lee

Cheng

Lin

et al. 2018

Behavioural Neurology

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“…Phantom boarder phenomenon and paranoid ideation were the most common delusion in these disorders. Finally, it has been shown that patients with DLB who presented delusions have higher disease severity, more neuropsychiatric symptoms and are more cognitively impaired ( 58 ). Frequent and distressing delusions in DLB have been associated with higher caregiver burden and with worse patient's quality of life compared with patients with other neurodegenerative disorders ( 58 ).…”

Section: Delusions In Neurodegenerative Disordersmentioning

confidence: 99%

Delusion and Delirium in Neurodegenerative Disorders: An Overlooked Relationship?

et al. 2022

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Delusions are part of the neuropsychiatric symptoms that patients suffering from neurodegenerative conditions frequently develop at some point of the disease course and are associated with an increased risk of cognitive and functional decline. Delirium is a syndrome characterized by acute onset of deficits in attention, awareness, and cognition that fluctuate in severity over a short time period. Delusions and delirium are frequently observed in the context of neurodegeneration, and their presence can easily mislead clinicians toward a misdiagnosis of psychiatric disorder further delaying the proper treatment. Risk factors for developing delusion and delirium in neurodegenerative conditions have been investigated separately while the possible interplay between these two conditions has not been explored so far. With this study, we aim to achieve a more comprehensive picture of the relationship between delusions and delirium in neurodegeneration by analyzing prevalence and subtypes of delusions in different neurodegenerative disorders; providing an overview of clinical tools to assess delusions in neurodegenerative patients and how delusions are covered by delirium assessment tools and discussing the possible common pathophysiology mechanisms between delusion and delirium in neurodegenerative patients. A more extensive characterization of the relationship between delusions and delirium may help to understand whether delusions may constitute a risk factor for delirium and may ameliorate the management of both conditions in patients with neurodegenerative disorders.

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“…20 Common delusions observed in patients with DLB include misidentification delusions (52.4%), delusions of others stealing (35.3%), delusions of danger to self (21.3%), and delusions of spousal infidelity (7.2%). 21,22 Of the misidentification delusion subtype, the most common delusions are house misidentification, Capgras delusions (belief that someone familiar has been replaced by an imposter), and reduplicative amnesia (belief that a place has been duplicated and is present in 2 locations simultaneously). Delusions and greater cognitive decline have been associated in DLB.…”

Section: Dementia With Lewy Bodiesmentioning

confidence: 99%

Barriers to Treatment of Hallucinations and Delusions in People With Dementia Residing in Long-Term Care

Khanna¹,

White²,

Bessey³

et al. 2022

J. Clin. Psychiatry

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Importance: Most people with dementia will experience neuropsychiatric symptoms, including psychosis characterized by hallucinations and delusions. Across dementia subtypes, hallucinations and delusions are common, though their prevalence and presentation may vary. These symptoms have been associated with worse outcomes compared with dementia alone, including accelerated functional decline and mortality. Many people with dementia reside in long-term care facilities, and identification and management of hallucinations and delusions in this setting are critical. Observations: For residents in long-term care facilities, the following factors can hinder management of hallucinations and delusions related to dementia: (1) delayed recognition of symptoms; (2) reluctance of staff and family members to acknowledge psychiatric issues; (3) lack of approved pharmacotherapies to treat hallucinations and delusions associated with dementia-related psychosis; and (4) regulatory and institutional guidelines, including the long-term care regulatory guidelines established by the Centers for Medicare and Medicaid Services and the 5-star rating system. Conclusions and Relevance: Barriers to the treatment of hallucinations and delusions in patients with dementia in the long-term care setting are myriad and complex. Early diagnosis of dementia-related psychosis and new treatment options for managing hallucinations and delusions are needed to improve care of this patient population.

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Delusions in Patients with Dementia with Lewy Bodies and the Associated Factors

Cited by 12 publications

References 36 publications

Quality of Life in Patients with Dementia with Lewy Bodies

Quality of Life in Patients with Dementia with Lewy Bodies

Delusion and Delirium in Neurodegenerative Disorders: An Overlooked Relationship?

Barriers to Treatment of Hallucinations and Delusions in People With Dementia Residing in Long-Term Care

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