“…DELTEX family in human is composed of five members, namely DTX1, DTX2, DTX3, DTX4 and DTX3L (Takeyama et al, 2003; Wang et al, 2021). Different family members have distinct N-terminal domains, either WWE domains (in DTX1, DTX2 and DTX4), or KH domain(s) (in DTX3 and DTX3L)(Figure EV8) (Zhu et al, 2023). WWE domains in proteins are known to bind poly(ADP-ribose) chains (DaRosa et al , 2015) whereas KH domains are known for binding to single stranded nucleic acids (Nicastro et al , 2015a; Suskiewicz et al , 2023a; Valverde et al , 2008).…”