Delta sleep-inducing peptide

Pollard, B. J.; Pomfrett, C.J.D.

doi:10.1046/j.1365-2346.2001.00917.x

Cited by 10 publications

(9 citation statements)

References 37 publications

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“…In the following three decades, extensive studies carried out in a number of laboratories (the total DSIP bibliography could be estimated at not less than 1500 references; Myers 1994) have demonstrated that DSIP, or some structurally closely related peptide(s), is present in both free and bound forms in some cerebral structures, primarily the hypothalamus and limbic system, as well as pituitary and different peripheral organs, tissues and body fluids, where it co‐localizes with several peptide and non‐peptide mediators (Graf and Kastin 1984, 1986; Schoenenberger 1984; Kovalzon 1986, 1994; Inoué and Schneider‐Helmert 1988; Yehuda et al . 1988; Inoué 1989; Bjartell 1990; Inoué and Kruger 1990; Prudchenko and Mikhaleva 1994; Lysenko and Mendzheritsky 1995; Strekalova 1998; Pollard and Pomfrett 2001).…”

Section: Structure Of Delta Sleep‐inducing Peptide (Dsip) and Dermorpmentioning

confidence: 99%

“…1994; Lysenko et al. 1995; Strekalova 1998; Pollard and Pomfrett 2001); stimulates the secretion of luteinizing hormone; stimulates the release of somatoliberin and somatotropin and inhibits somatostatin secretion (Kovalzon 1994). …”

Section: Structure Of Delta Sleep‐inducing Peptide (Dsip) and Dermorpmentioning

confidence: 99%

“…1994; Lysenko et al. 1995; Strekalova 1998; Gershtein and Dovedova 1999; Pollard and Pomfrett 2001); immune responses, where it can play the role of immunomodulator, cell differentiation factor and anti‐tumour agent (Prudchenko et al . 1993b; Fabien et al .…”

Section: Structure Of Delta Sleep‐inducing Peptide (Dsip) and Dermorpmentioning

confidence: 99%

“…1984, 1986; Schoenenberger 1984; Yehuda and Mostofsky 1984; Yehuda et al. 1988; Bjartell 1990; Strekalova 1998; Pollard and Pomfrett 2001). A close correlation between the diurnal rhythm of DSIP‐LI and that of body temperature was detected.…”

Section: Structure Of Delta Sleep‐inducing Peptide (Dsip) and Dermorpmentioning

confidence: 99%

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Delta sleep‐inducing peptide (DSIP): a still unresolved riddle

Kovalzon

Strekalova

2006

Journal of Neurochemistry

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Delta sleep-inducing peptide (DSIP) was isolated from rabbit cerebral venous blood by Schoenenberger-Monnier group from Basel in 1977 and initially regarded as a candidate sleep-promoting factor. However, the link between DSIP and sleep has never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor. Thus the hypothesis regarding DSIP as a sleep factor is extremely poorly documented and still weak. Although DSIP itself presented a focus of study for a number of researchers, its natural occurrence and biological activity still remains obscure. DSIP structure is different from any other known representative of the various peptide families. In this mini-review we hypothesize the existence of a DSIP-like peptide(s) that is responsible (at least partly) for DSIP-like immunoreactivity and DSIP biological activity. This assumption is based on: (i) a highly specific distribution of DSIP-like immunoreactivity in the neurosecretory hypothalamic nuclei of various vertebrate species that are not particularly relevant for sleep regulation, as revealed by the histochemical studies of the Geneva group (Charnay et al.); (ii) a large spectrum of DSIP biological activity revealed by biochemical and physiological studies in vitro; (iii) significant slow-wave sleep (SWS) promoting activity of certain artificial DSIP structural analogues (but not DSIP itself!) in rabbits and rats revealed by our early studies; and (iv) significant SWS-promoting activity of a naturally occurring dermorphin-decapeptide that is structurally similar to DSIP (in five of the nine positions) and the sleep-suppressing effect of its optical isomer, as revealed in rabbits. Potential future studies are outlined, including natural synthesis and release of this DSIP-like peptide and its role in neuroendocrine regulation.

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Section: Structure Of Delta Sleep‐inducing Peptide (Dsip) and Dermorpmentioning

confidence: 99%

Section: Structure Of Delta Sleep‐inducing Peptide (Dsip) and Dermorpmentioning

confidence: 99%

Section: Structure Of Delta Sleep‐inducing Peptide (Dsip) and Dermorpmentioning

confidence: 99%

Section: Structure Of Delta Sleep‐inducing Peptide (Dsip) and Dermorpmentioning

confidence: 99%

See 2 more Smart Citations

Delta sleep‐inducing peptide (DSIP): a still unresolved riddle

Kovalzon

Strekalova

2006

Journal of Neurochemistry

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“…Anabolic activity of delta sleep-inducing peptide depended on the purpose of adaptation corresponding to the type of stress.Delta sleep-inducing peptide (Trp-Ala-Gly-Gly-AspAla-Ser-Gly-Glu, DSIP) is an endogenous neuromodulator with a wide range of biological properties [4][5][6]. This peptide increases organism's resistance to stress, alleviates stress-induced abnormalities, and maintains metabolic processes at the physiological level.…”

mentioning

confidence: 99%