“…In addition, D SIP has been shown to inhibit the release and actions of corticotropin-releasing factor (C'RF) [11 ,22,33]. In man, ef fects on higher mental functions o f synthetic D SIP injected intravenously have also been described [26], DSIP-like immunoreactivity has been demonstrated by radioimmunoassay (RIA) and immunocytochemistry in the rat central nervous system [4,8,9], and by R IA in several peripheral organs of the rat, including the adrenals [10] as well as in plasma o f several mammals [1.9, 12]. The exact nature of the immunoreactive material in tissue extracts and body fluids is still a matter of discussion [7 ,9 ,1 0 ,12].…”