Delta sleep-inducing peptide and Deltaran: Potential approaches to antistress protection

Коплик, Е. В.; Umryukhin, P. E.; Конорова, И. Л.; Terekhina, O. L.; Mikhaleva, I. I.; Gannushkina, I. V.; Судаков, К. В.

doi:10.1007/s11055-008-9076-4

Cited by 9 publications

(3 citation statements)

References 4 publications

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“…A reduced volume of infarction in ischemic tissues may be due to the ability of DSIP (and possibly its analogs) to increase the blood flow in the tissues [4]. Increased cerebral blood flow and a decrease in mortality after cerebral ischemia were demonstrated in the study by Koplik et al [18], in which male Wistar rats were subjected to global cerebral ischemia caused by bilateral occlusion of the carotid arteries, and preventively received DSIP at a dose of 10 µg/kg.…”

Section: Discussionmentioning

confidence: 99%

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

et al. 2021

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A structural analogue of the DSIP, peptide KND, previously showed higher detoxification efficacy upon administration of the cytotoxic drug cisplatin, compared to DSIP. DSIP and KND were investigated using the model of acute myocardial infarction in male SD rats and the model of acute focal stroke in C57Bl/6 mice. A significant decrease in the myocardial infarction area was registered in KND-treated animals relative to saline-treated control animals (19.1 ± 7.3% versus 42.1 ± 9.2%). The brain infarction volume was significantly lower in animals intranasally treated with KND compared to the control saline-treated animals (7.4 ± 3.5% versus 12.2 ± 5.6%). Injection of KND in the first minute of reperfusion in the models of myocardial infarction and cerebral stroke reduced infarction of these organs, indicating a pronounced cardioprotective and neuroprotective effect of KND and potentiality for the treatment of ischemia-reperfusion injuries after transient ischemic attacks on the heart and brain, when administered during the reperfusion period. A preliminary pilot study using the model of myocardial infarction with the administration of DSIP during occlusion, and the model of cerebral stroke with the administration of KND during occlusion, resulted in 100% mortality in animals. Thus, in the case of ischemia-reperfusion injuries of the myocardium and the brain, use of these peptides is only possible during reperfusion.

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Section: Discussionmentioning

confidence: 99%

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

et al. 2021

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“…Therefore, additional structural changes or coupling are necessary to ensure intestinal membrane permeability for DSIP [52]. A successful attempt in DSIP application was the creation of Deltaran in which DSIP is combined with glycine for intranasal administration of an aqueous solution [53]. Subsequent studies demonstrated geroprotective, anticarcinogenic and neuroprotective effects of DSIP and Deltaran [53,54].…”

Section: Discussionmentioning

confidence: 99%

Modulatory effects of delta sleep-inducing peptide in a lindane model of generalized seizures

Hrnčić¹,

Grubač²,

Šutulović³

et al. 2018

ARCH BIOL SCI BELGRA

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“…Accordingly, the treatment of Wistar rats with DSIP several hours prior to global brain ischemia improved locomotor functions and reduced lethality [ 23 ]. DSIP reduced neuronal activity and improved blood supply of the brain of stressed animals subjected to brain ischemia [ 24 ]. There are several reports suggesting that DSIP reduces stress-induced overproduction of free radicals in CNS and prevents neuronal death [ 16 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke

et al. 2021

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Background and Objectives: Mutual effect of the preliminary and therapeutic intranasal treatment of SD rats with DSIP (8 days) on the outcome of focal stroke, induced with intraluminal middle cerebral occlusion (MCAO), was investigated. Materials and Methods: The groups were the following: MCAO + vehicle, MCAO + DSIP, and SHAM-operated. DSIP or vehicle was applied nasally 60 (±15) minutes prior to the occlusion and for 7 days after reperfusion at dose 120 µg/kg. The battery of behavioral tests was performed on 1, 3, 7, 14, and 21 days after MCAO. Motor coordination and balance and bilateral asymmetry were tested. At the end of the study, animals were euthanized, and their brains were perfused, serial cryoslices were made, and infarction volume in them was calculated. Results: Although brain infarction in DSIP-treated animals was smaller than in vehicle-treated animals, the difference was not significant. However, motor performance in the rotarod test significantly recovered in DSIP-treated animals. Conclusions: Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.

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Delta sleep-inducing peptide and Deltaran: Potential approaches to antistress protection

Cited by 9 publications

References 4 publications

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

Modulatory effects of delta sleep-inducing peptide in a lindane model of generalized seizures

Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke

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