Delta oscillation underlies the interictal spike changes after repeated transcranial direct current stimulation in a rat model of chronic seizures

Wu, Yuan-Hua; Chien, Miao Er; Chiang, Chia Chu; Huang, Ying Zu; Durand, Dominique M.

doi:10.1016/j.brs.2021.04.025

Cited by 9 publications

(5 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1F). Although comparison of the spectral bands before and after the IEDs in the theta (4-10 Hz), gamma (30-70 Hz) and high-frequency oscillations (80 – 160 Hz) bands showed no significant difference (theta p = 0.277, gamma p = 0.749, HFO p=0.338), likely due to the small number of sessions, the direction of changes (increased gamma power and decreased 80 – 160 Hz band power) was similar to those reported previously (Wu et al, 2021; Meisenhelter et al, 2021).…”

Section: Resultssupporting

confidence: 88%

Interictal epileptiform discharges affect memory in an Alzheimer’s Disease mouse model

Soula

Maslarova

Harvey

et al. 2023

Preprint

View full text Add to dashboard Cite

Interictal epileptiform discharges (IEDs) are transient abnormal electrophysiological events commonly observed in epilepsy patients but are also present in other neurological disease, such as Alzheimer's disease (AD). Understanding the role IEDs have on the hippocampal circuit is important for our understanding of the cognitive deficits seen in epilepsy and AD. We characterize and compare the IEDs of human epilepsy patients from microwire hippocampal recording with those of AD transgenic mice with implanted multi-layer hippocampal silicon probes. Both the local field potential features and firing patterns of pyramidal cells and interneurons were similar in mouse and human. We found that as IEDs emerged from the CA3-1 circuits, they recruited pyramidal cells and silenced interneurons, followed by post-IED suppression. IEDs suppressed the incidence and altered the properties of physiological sharp-wave ripples (SPW-Rs), altered their physiological properties, and interfered with the replay of place field sequences in a maze. In addition, IEDs in AD mice inversely correlated with daily memory performance. Together, our work implicates that IEDs may present a common and epilepsy-independent phenomenon in neurodegenerative diseases that perturbs hippocampal-cortical communication and interferes with memory.

show abstract

Section: Resultssupporting

confidence: 88%

Interictal epileptiform discharges affect memory in an Alzheimer’s Disease mouse model

Soula

Maslarova

Harvey

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Results showed that recurrent c-tDCS reduced interictal spikes, increased low-frequency delta oscillation, decreased high-frequency gamma and beta oscillation, and lowered hippocampal brain-derived neurotrophic factor (BDNF) protein expression. These results suggest that c-tDCS have an inhibitory effect on neuronal excitability in the epileptic brain by enhancing the endogenous delta oscillation (42). In 2020, researchers examined the effect of tDCS on seizure severity, EEG activity, and post-SE outcomes in rats' kainic acid-induced SE model.…”

Section: Animal Studiesmentioning

confidence: 99%

The effect of transcranial direct current stimulation (tDCS) on seizure control and epilepsy prevention

Zahedi,

Atabaki,

Khaleghzadeh-Ahangar

2023

Acta fac medic Naissensis

View full text Add to dashboard Cite

Introduction. Epilepsy is one of the most common neurological diseases. It is an uncontrollable neuronal activity of different parts of the brain leading to convulsion and/or fainting. Although epileptic seizure control and therapeutics have significant advances, 20% -30% of individuals still have uncontrolled seizures. Patients under the medication's control are not free from the drug's side effects and complications. Epileptic patients experience many different challenges. Transcranial direct current stimulation (tDCS) is a safe and non-invasive brain stimulation method applied in drug-resistant seizures and epilepsies. It transmits positive/negative electrical current toward deep brain parts, modulating their electrical activity. Methods. This is a review article. All relevant articles which were accessible were reviewed. The effectiveness of tDCS in preventing epilepsy in patients undergoing seizures was reviewed in this article. Conclusion. According to the studies, this method can probably be an auxiliary method in preventing and treating seizures. As epileptic seizures were induced and confirmed in some studies after the application of tDCS, the method should be cautiously applied.

show abstract

“…Antiepileptic therapies can cause side effects, such as rebound excitations, followed by the application of inhibitory stimuli. Acute rebound effects of AEDs [10,11], VNS, DBS [12][13][14], and TMS [15,16], are prolonged, probably because of neuronal plasticity [17,18]. The stimulus frequency [13,19,20] and length [21,22] are significant factors inducing rebound.…”

Section: Introductionmentioning

confidence: 99%

“…The stimulus frequency [13,19,20] and length [21,22] are significant factors inducing rebound. In electrical stimulations, brief stimuli can cause temporary rebound, followed by short inhibition [17,23]. Moreover, fast successive stimulations could exhaust GABA and reinforce excitatory effects, ultimately breaking inhibitory functions [2].…”

Section: Introductionmentioning

confidence: 99%

Rebound Excitation of Epileptiform Activities by Transcranial Focused Ultrasound Stimulation

Choi

Koo

Joo

et al. 2022

Preprint

View full text Add to dashboard Cite

BackgroundConventional neurostimulations to treat epilepsy have adverse effects caused by post-inhibitory rebound excitations. Although ultrasound brain stimulation is feasible in inducing anticonvulsant effects, its association with paradoxical rebound excitations is unknown.ObjectiveThis study aimed at demonstrating rebound excitations with transcranial focused ultrasound. The modulations of epileptiform activities toward both suppressive and excitatory responses were investigated by changing ultrasonic transmit sequences.MethodsIn a pentylenetetrazol-injected acute epilepsy rat model, transcranial focused ultrasound stimulation was applied on the thalamus to modulate epileptiform activities. The parameters differentiated for pulse sequences were the pulse length, pulse pressure, and interval between the pulses. Sonication effects were assessed by electroencephalography (n=38), immuno-histochemical analysis (n=24), and optical measurement of cerebral blood volume changes (n=18).ResultsWhile ultrasonic patterns of stimuli at long intervals showed antiepileptic effects on electroencephalography, those at short intervals showed rebound excitatory responses followed by inhibitory activities. Further, suppressive states induced by inhibitory stimulations were transformed into excitatory states by applying a consecutive series of short bursts at higher acoustic pressure. Cerebral blood volume changes demonstrated consistent results with electroencephalography. Immunohistochemistry revealed that both inhibitory and excitatory neuronal cells were activated to generate rebound excitatory conditions, while inhibitory cells were activated for suppressive conditions.ConclusionsIn our study, variations in ultrasound stimulation patterns could modulate epileptiform activities in both upregulated and downregulated directions.

show abstract

Delta oscillation underlies the interictal spike changes after repeated transcranial direct current stimulation in a rat model of chronic seizures

Cited by 9 publications

References 53 publications

Interictal epileptiform discharges affect memory in an Alzheimer’s Disease mouse model

Interictal epileptiform discharges affect memory in an Alzheimer’s Disease mouse model

The effect of transcranial direct current stimulation (tDCS) on seizure control and epilepsy prevention

Rebound Excitation of Epileptiform Activities by Transcranial Focused Ultrasound Stimulation

Contact Info

Product

Resources

About