Delta-Aminolevulinic Acid Dehydratase (Alad) Genetic Polymorphism in Turkish Population : Türk Populasyonunda Delta-Ami̇nolevuli̇ni̇k Asi̇t Dehi̇drataz (Alad) Geneti̇k Poli̇morfi̇zmi̇

Süzen, Sinan

doi:10.1501/eczfak_0000000353

Cited by 2 publications

(1 citation statement)

References 22 publications

(28 reference statements)

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“…In addition, the enzyme Delta-aminolevulinic acid dehydratase (ALAD) is adversely affected by lead [41,43]. As a result of the lead effect, D-aminolevulinic acid (ALA) accumulation is observed and this accumulation increases the amount of ROS and thus causes the formation of oxidative stress.…”

Section: Relationship Of Lead With Ros and Oxidative Stressmentioning

confidence: 99%

Relationship of Lead With Free Radicals, Reactive Oxygen Species, Oxidative Stress and Antioxidant Enzymes

VURAL AYDIN

2024

Eskişehir Teknik Üniversitesi Bilim Ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji

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Heavy metals, which are high in the environment, are substances that have a high toxic effect even at low concentrations. Heavy metals taken into the organism through mouth, respiration and skin cannot be eliminated by the body's excretory pathways. In addition, since they have a durable structure, they participate in the food chain and accumulate in various body tissues. With the increase in industrial activities, heavy metal pollution has also emerged and has increased day by day. Lead is an element that is widely used in industry because it has a low melting temperature. However, it is known that lead, like other heavy metals, has an effect on problems such as environmental pollution and health problems. Occupational diseases such as lead poisoning occur as a result of direct exposure to lead. Direct exposure in this way can also cause death. Lead causes undesirable conditions such as increase of reactive oxygen species (ROS), emergence of oxidative stress and weakening of antioxidant system. Lead disrupts the prooxidant/antioxidant ratio. As a result, effects such as an increase in ROS and thus damage to the basic components of the cell such as lipid, protein and nucleic acid are observed.In particular, lead inhibits enzymes and prevents some enzymes from acting as antioxidants. As a result of exposure to lead, there is a decrease in the defense abilities of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), glutathione (GSH) and ascorbic acid in blood and tissues. Lead increases lipid peroxidation and thus causes oxidative damage. Evaluation of the effect of lead at the cellular level is important in terms of developing solutions for the toxic effects of lead. In this study, the effect of lead on the cellular level in the organism and its effects on free radicals, ROS and oxidative stress were evaluated.

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Section: Relationship Of Lead With Ros and Oxidative Stressmentioning

confidence: 99%

Relationship of Lead With Free Radicals, Reactive Oxygen Species, Oxidative Stress and Antioxidant Enzymes

VURAL AYDIN

2024

Eskişehir Teknik Üniversitesi Bilim Ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji

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Molecular Analysis of -Aminolevulinic Acid Dehydratase (ALAD) Gene Polymorphism in a Turkish Population

Süzen

Duydu

Aydın³

2004

Biochem Genet

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delta-Aminolevulinic acid dehydratase (ALAD) is a cytosolic enzyme in the heme biosynthetic pathway. ALAD is a polymorphic enzyme showing marked ethnic group differences. In this study, ALAD polymorphism is studied in a Turkish population. Genomic DNA extracted from 230 individuals and polymerase chain reaction (PCR) coupled with the restriction fragment length polymorphism (RFLP) technique were used to identify variants. The frequencies of the alleles ALAD1 and ALAD2 in Turkey were 0.887 and 0.113, respectively. This study provides the first analysis of the allele frequency distribution of the ALAD gene in a Turkish population. The results are compared with other world populations.

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Delta-Aminolevulinic Acid Dehydratase (Alad) Genetic Polymorphism in Turkish Population : Türk Populasyonunda Delta-Ami̇nolevuli̇ni̇k Asi̇t Dehi̇drataz (Alad) Geneti̇k Poli̇morfi̇zmi̇

Abstract: Delta-aminolevulinic acid dehydratase (ALAD) is an enzyme involved in

Cited by 2 publications

References 22 publications

Relationship of Lead With Free Radicals, Reactive Oxygen Species, Oxidative Stress and Antioxidant Enzymes

Relationship of Lead With Free Radicals, Reactive Oxygen Species, Oxidative Stress and Antioxidant Enzymes

Molecular Analysis of -Aminolevulinic Acid Dehydratase (ALAD) Gene Polymorphism in a Turkish Population

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