Delivery systems of therapeutic nucleic acids for the treatment of acute lung injury/acute respiratory distress syndrome

Zhuang, Chuanyu; Kang, Minji; Lee, Minhyung

doi:10.1016/j.jconrel.2023.06.018

Cited by 10 publications

(3 citation statements)

References 140 publications

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“…Among the various complications associated with sepsis, pulmonary injury is particularly severe [ 17 ]. Acute lung injury (ALI) is a clinical syndrome marked by an excessive inflammatory response, increased pulmonary capillary permeability, and severe hypoxemia [ 18 ]. Acute respiratory distress syndrome (ARDS), which has a high mortality rate, can result from ALI in severe cases [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

GDF3 Protects Mice against Sepsis-Induced Acute Lung Injury by Suppression of Macrophage Pyroptosis

Lei,

Wang,

Zou

et al. 2024

Pharmaceuticals

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Sepsis-induced ALI is marked by physiological, pathological, and biochemical irregularities caused by infection. Growth differentiation factor 3 (GDF3) is closely associated with the inflammatory response. Accumulating evidence has demonstrated a close relationship between GDF3 expression and the severity and prognosis of sepsis. However, the precise mechanism by which GDF3 protects against ALI induced by sepsis is still unclear. Following the intravenous administration of GDF3 in this research, we noted a rise in the survival rate, a decrease in the severity of histopathological damage as evaluated through HE staining, a decline in the count of inflammatory cells in bronchoalveolar lavage fluid (BALF), a reduction in the ratio of lung wet/dry (W/D) weight, and a noteworthy decrease in the levels of pro-inflammatory cytokines in both serum and BALF when compared to septic mice who underwent cecal ligation and puncture (CLP). These collective findings unequivocally indicate the protective effects of GDF3 against sepsis-induced ALI. In addition, the GDF3 group showed a significant reduction in the mRNA expression of Caspase-1 and NLRP3 when compared to the CLP group. Following this, we performed in vitro tests to confirm these discoveries and obtained comparable outcomes, wherein the administration of GDF3 notably decreased the levels of Caspase-1 and NLRP3 mRNA and protein in macrophages in comparison to the LPS group. Furthermore, GDF3 exhibited the capacity to reduce the secretion of inflammatory molecules from macrophages. By illuminating the mechanism by which GDF 3 regulates macrophages, this offers a theoretical basis for preventing and treating sepsis-induced ALI.

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Section: Discussionmentioning

confidence: 99%

GDF3 Protects Mice against Sepsis-Induced Acute Lung Injury by Suppression of Macrophage Pyroptosis

Lei,

Wang,

Zou

et al. 2024

Pharmaceuticals

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“…ALI is mainly characterized by alveolar epithelial cell damage, pulmonary interstitial edema, and neutrophil infiltration ( 103 ). Clinically, the main symptoms are decreased lung compliance and bilateral pulmonary inflammatory infiltrates in hypoxemia ( 104 ). Ferroptosis is the main driver of ischemia-reperfusion injury (I/R) and is closely related to the pathogenesis of lipopolysaccharide (LPS) -induced septic ALI, and can aggravate further tissue and organ damage ( 73 , 105 ).…”

Section: Ferroptosis In Pulmonary Diseasementioning

confidence: 99%

A deep insight into ferroptosis in lung disease: facts and perspectives

Zhang,

Xiang,

et al. 2024

Front. Oncol.

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In the last decade, ferroptosis has received much attention from the scientific research community. It differs from other modes of cell death at the morphological, biochemical, and genetic levels. Ferroptosis is mainly characterized by non-apoptotic iron-dependent cell death caused by iron-dependent lipid peroxide excess and is accompanied by abnormal iron metabolism and oxidative stress. In recent years, more and more studies have shown that ferroptosis is closely related to the occurrence and development of lung diseases. COPD, asthma, lung injury, lung fibrosis, lung cancer, lung infection and other respiratory diseases have become the third most common chronic diseases worldwide, bringing serious economic and psychological burden to people around the world. However, the exact mechanism by which ferroptosis is involved in the development and progression of lung diseases has not been fully revealed. In this manuscript, we describe the mechanism of ferroptosis, targeting of ferroptosis related signaling pathways and proteins, summarize the relationship between ferroptosis and respiratory diseases, and explore the intervention and targeted therapy of ferroptosis for respiratory diseases.

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“…Theoretically, gene therapy can achieve lasting or even curative effects. Later in 2019, nucleic acid delivery systems were developed rapidly in order to better prevent and treat pneumonia caused by COVID-19 infection [78][79][80]. In addition to antisense oligonucleotides (ASOs) and mRNAs, which have been extensively studied, miRNAs also have great potential for drug development due to their stability and prominent position in regulating gene expression.…”

Section: Mirnas In Onfhmentioning

confidence: 99%

Insight into Steroid-Induced ONFH: The Molecular Mechanism and Function of Epigenetic Modification in Mesenchymal Stem Cells

Huang,

Qing,

Xiao

et al. 2023

Biomolecules

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Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease, which is one of the common causes of hip pain and dysfunction. ONFH has a very high disability rate, which is associated with a heavy burden to patients, families, and society. The pathogenesis of ONFH is not completely clear. At present, it is believed that it mainly includes coagulation dysfunction, abnormal lipid metabolism, an imbalance of osteogenic/adipogenic differentiation, and poor vascularization repair. The prevention and treatment of ONFH has always been a great challenge for clinical orthopedic surgeons. However, recent studies have emphasized that the use of mesenchymal stem cells (MSCs) to treat steroid-induced ONFH (SONFH) is a promising therapy. This review focuses on the role and molecular mechanism of epigenetic regulation in the progress of MSCs in the treatment of SONFH, and discusses the significance of the latest research in the treatment of SONFH from the perspective of epigenetics.

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Delivery systems of therapeutic nucleic acids for the treatment of acute lung injury/acute respiratory distress syndrome

Cited by 10 publications

References 140 publications

GDF3 Protects Mice against Sepsis-Induced Acute Lung Injury by Suppression of Macrophage Pyroptosis

GDF3 Protects Mice against Sepsis-Induced Acute Lung Injury by Suppression of Macrophage Pyroptosis

A deep insight into ferroptosis in lung disease: facts and perspectives

Insight into Steroid-Induced ONFH: The Molecular Mechanism and Function of Epigenetic Modification in Mesenchymal Stem Cells

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