Delivery systems for the administration of drugs to the periodontal pocket

In situ forming gel comprising bleached shellac loaded with antimicrobial drugs for periodontitis treatment

“…The treatment of periodontitis by these intra-pocket antibacterial delivery systems is interesting due to the prospects of maintaining effective high levels of drug in the gingival crevicular fluid for a prolonged period of time to produce the desirable clinical benefits [2]. Chitosan gels comprising metronidazole demonstrated the effectiveness in the periodontitis treatment [3].…”

Formulation and release of doxycycline HCL from an ion activated in situ gelling delivery system for the treatment of periodontal disease

“…20 Such agents were studied in a variety of specialized systems like fibers, films, microparticles, semisolids, and gels to maintain the antimicrobial agents in the gingival crevicular fluid (GCF) at a bactericidal concentration for the required period of therapy. 21 Ion activated in situ gel-forming delivery systems have been studied mainly for ophthalmic drug delivery where they exhibit reversible phase transition (sol-gel-sol) and pseudoplastic behavior. 22,23 Such systems were aiming at gel formation upon exposure to physiological conditions, and thus increasing the pre-corneal residence time of the delivery system and improving the ocular bioavailability.…”

Formulation development of smart gel periodontal drug delivery system for local delivery of chemotherapeutic agents with application of experimental design

“…It is a localized inflammatory response due to accumulation of sub-gingival plaque (Medlicott et al, 1994). Various periodontal drug delivery systems (PDDS) have been reviewed for local delivery of chemotherapeutic agents (Flotra, 1973;Pitcher et al, 1980;Greenstein, 1987;Jones et al, 1996).…”