Delivery Systems and Role of Growth Factors for Alveolar Bone Regeneration in Dentistry

Biagi, Marleen De; Brunello, Giulia; Ricci, Drazen Tadic Sara; Marinc, Christiane; Lops, Diego; Ferroni, Letizia; ChiaraGardin,; Bressan, Eriberto; Zavan, Barbara

doi:10.5772/55580

Cited by 6 publications

(18 citation statements)

References 78 publications

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“…With regard to the incorporation of bioactive molecules for localized and controlled delivery [18,19], in one study [115] VEGF, a potent angiogenic factor, was successfully encapsulated within a PEEK/biphasic bioceramic composite scaffold and found to facilitate the vascular remodeling in vivo.…”

Section: Discussionmentioning

confidence: 99%

“…Another strategy to produce scaffolds with tailored mechanical properties and resorbability, based on application needs, consists of the development of composite materials, containing bioceramics and polymers in different ratios [16,17]. To improve the performances of bioceramic scaffolds, the incorporation of growth factors stimulating osteogenesis and angiogenesis has been described [18,19]. Moreover, bone scaffolds could act as stem cell carriers for accelerating bone repair [20].…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Bioceramic Scaffolds on Bone Regeneration in Preclinical In Vivo Studies: A Systematic Review

et al. 2020

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Bioceramic scaffolds are appealing for alveolar bone regeneration, because they are emerging as promising alternatives to autogenous and heterogenous bone grafts. The aim of this systematic review is to answer to the focal question: in critical-sized bone defects in experimental animal models, does the use of a bioceramic scaffolds improve new bone formation, compared with leaving the empty defect without grafting materials or using autogenous bone or deproteinized bovine-derived bone substitutes? Electronic databases were searched using specific search terms. A hand search was also undertaken. Only randomized and controlled studies in the English language, published in peer-reviewed journals between 2013 and 2018, using critical-sized bone defect models in non-medically compromised animals, were considered. Risk of bias assessment was performed using the SYRCLE tool. A meta-analysis was planned to synthesize the evidence, if possible. Thirteen studies reporting on small animal models (six studies on rats and seven on rabbits) were included. The calvarial bone defect was the most common experimental site. The empty defect was used as the only control in all studies except one. In all studies the bioceramic materials demonstrated a trend for better outcomes compared to an empty control. Due to heterogeneity in protocols and outcomes among the included studies, no meta-analysis could be performed. Bioceramics can be considered promising grafting materials, though further evidence is needed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Impact of Bioceramic Scaffolds on Bone Regeneration in Preclinical In Vivo Studies: A Systematic Review

et al. 2020

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“…14 Consequently, a recombinant isoform of PDGF (rhPDGF-BB) was synthesized and found to be potent in exerting chemotactic and osteoproliferative actions through cell surface tyrosine kinase receptors. 22 While several studies have reported beneficial effects on bone healing when combining rhP-DGF-BB with osteoconductive scaffolds, 10,12,21,[30][31][32][33] the present study evaluated the adjunct role of rhPDGF-BB along with equine bone and beta-TCP for GBR of segmental defects (femoral CSSD), which has not been reported earlier. Although, BMPs and MSCs have been reported as adjuncts to GBR, they are associated with disadvantages, such as uncontrolled bone formation seen with BMPs and difficulty in cell culture and isolation of MSCs.…”

Section: Discussionmentioning

confidence: 95%

“…Healing bone tissue expresses BMP and PDGF for mesenchymal cell differentiation and proliferation, and the addition of these factors could potentially render osteoconductive graft materials as osteoinductive. 6,22 PDGF is released from the alpha-granules of platelets in response to injury and is chemically characterized as a dimer derived from PDGF-A/B polypeptide chains. 28,29 Interestingly, PRP which is considered to release PDGF through platelet lysis, availed no clinical benefit towards osseous healing and regeneration.…”

Section: Discussionmentioning

confidence: 99%

“…19,20 Several clinical and pre-clinical studies have reported successful bone growth with GBR using different osteoconductive materials and resorbable collagen membrane (RCM). 8,11,[19][20][21][22][23][24][25] Considering the above facts, it is indeed alluring to hypothesize that GBR could be used for reconstruction and regeneration of SBDs, which are otherwise treatable only with large quantities of autografts. 5,18 GBR as a tissue engineering strategy could facilitate the use of a promising triad of osteoconductive scaffolds, stem cells, and growth factors for bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

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Guided bone regeneration with osteoconductive grafts and PDGF: A tissue engineering option for segmental bone defect reconstruction

Alkindi

Ramalingam

Alghamdi

et al. 2021

Journal of Applied Biomaterials & Functional Materials

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Regeneration and reconstruction of segmental bone defects (SBD) is a clinical challenge in maxillofacial surgery and orthopedics. The present study evaluated efficacy of guided bone-regeneration (GBR) of rat femoral SBD using osteoconductive equine-bone (EB) and beta-tricalcium phosphate (beta-TCP) grafts, either with or without platelet-derived growth-factor (PDGF). Following ethical-approval, 50 male Wistar-Albino rats (aged ~12–15 months and weighing ~450–500 g) were included. A 5 mm femoral critical-size SBD was created and animals were divided into five groups depending on the graft material used for GBR (EB, EB + PDGF, Autograft, beta-TCP, beta-TCP + PDGF; n = 10/group). Following 12-weeks of healing, animals were sacrificed and femur specimens were analyzed through qualitative histology and quantitative histomorphometry. There was new bone bridging femoral SBD in all groups and qualitatively, better bone formation was seen in autograft and EB + PDGF groups. Histomorphometric bone-area (BA %) was significantly high in autograft group, followed by EB + PDGF, beta-TCP + PDGF, EB, and beta-TCP groups. Addition of PDGF to EB and beta-TCP during GBR resulted in significantly higher BA%. After 12-weeks of healing, EB + PDGF for GBR of rat femoral segmental defects resulted in new bone formation similar to that of autograft. Based on this study, GBR with EB and adjunct PDGF could be a potential clinical alternative for reconstruction and regeneration of segmental bone defects.

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Powder-based 3D printing for bone tissue engineering

Brunello

Sivolella

Meneghello

et al. 2016

Biotechnology Advances

245

143

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Delivery Systems and Role of Growth Factors for Alveolar Bone Regeneration in Dentistry

Cited by 6 publications

References 78 publications

The Impact of Bioceramic Scaffolds on Bone Regeneration in Preclinical In Vivo Studies: A Systematic Review

The Impact of Bioceramic Scaffolds on Bone Regeneration in Preclinical In Vivo Studies: A Systematic Review

Guided bone regeneration with osteoconductive grafts and PDGF: A tissue engineering option for segmental bone defect reconstruction

Powder-based 3D printing for bone tissue engineering

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