Delivery room skin-to-skin contact in preterm infants affects long-term expression of stress response genes

Hucklenbruch‐Rother, Eva; Vohlen, Christina; Mehdiani, Nava; Keller, Titus; Roth, Bernhard; Kribs, Angela; Mehler, Katrin

doi:10.1016/j.psyneuen.2020.104883

Cited by 17 publications

(15 citation statements)

References 46 publications

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“…Previous studies have reported that early SSC with the mother promotes breastfeeding in late preterm and term newborns. 1,28,29 The increase in breastfeeding in the SSC group could result from early involvement and contact with the father through the SSC transfer and the earlier SSC with parents in the unit, which could sustain the mother in implementing and continuing breastfeeding.…”

Section: Discussionmentioning

confidence: 99%

Skin-to-Skin Contact for Transferring Preterm Infants from the Delivery Room to the Neonatal Intensive Care Unit Is Promising Despite Moderate Heat Loss during the Procedure

et al. 2022

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Objective: The principal aim of this prospective observational study was to assess the feasibility of skin-to-skin contact (SSC) with fathers during the transfer of preterm infants from the delivery room to the neonatal intensive care unit (NICU) in comparison with incubator transfers. Study design: The study population comprised preterm singletons born between May and December 2019 in our maternity ward who did not require invasive ventilation. Physiological parameters (axillary temperature, heart rate and fraction of inspired oxygen) of the newborns were recorded at prespecified steps during the transfers. The impact of the transfer mode on early blood glucose level, blood gas, neonatal morbidities and mortality, the delay in the first SSC in the NICU and breastfeeding implementation and maintenance were also analyzed. Results: Twenty-eight preterm infants were transferred in incubators, and 29 infants were transferred using SSC. The SSC transfer induced heat loss (mean 0.45°C, SD 0.58). However, the decrease in temperature was similar to that observed during transfer in the incubator (mean −0.30°C, SD 0.49, p = 0.3). The transfer using SSC was not an independent factor associated with hypothermia at admission in the NICU (adjusted OR 2.6 [0.68−9.75], p = 0.16). Neonatal morbidities and mortality were similar regardless the transfer mode. The SSC transfer promoted early SSC in the neonatal unit (median hour [range] incubator 26 [2−126] vs. SSC 13 [1−136], p = 0.03) and breastfeeding at discharge (incubator 35.7% vs. SSC 69%, p = 0.01). Conclusion: The SSC transfer of preterm infants was feasible and promoted earlier SSC and breastfeeding. Nevertheless, the SSC transfer like the transfer in the incubator induced moderate heat losses that exacerbated hypothermia at admission in the NICU. The improvement of thermal conservation during infant positioning, and the continuation of SSC in the unit could help in preventing hypothermia.

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Section: Discussionmentioning

confidence: 99%

Skin-to-Skin Contact for Transferring Preterm Infants from the Delivery Room to the Neonatal Intensive Care Unit Is Promising Despite Moderate Heat Loss during the Procedure

et al. 2022

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“…This new 2015-2020 integrative review added 15 articles (13 cohorts) all of which described kangaroo care being done for 15 min [50] to 2 h [51,52] starting as early as 24 weeks PMA [53]. Two studies evaluated kangaroo care specifically in the delivery room immediately after birth, starting at 25 weeks PMA [54,55]. The frequency of kangaroo care across studies varied and ranged from 1 time per day [50] to an average of 4 times per day [56,57].…”

Section: Tactilementioning

confidence: 99%

“…However, multimodal interventions often included a tactile component (see "Multimodal" section below). Positive outcomes associated with increased duration and/or frequency of kangaroo care included stabilized respiratory rate [58,61], improved maternal-infant attachment [54,55,61,62], decreased parental stress [50,54,55,61,63], lower heart rate [58,60], increased shortterm electromyographic activity of the biceps brachii and hamstrings [59], increased oxygen saturation [51], decreased infant salivary cortisol levels [64], increased salivary oxytocin levels for infants and parents [64], decreased anxiety for parents [64], decreased risk of early postpartum depression or impaired bonding [54,55], increased weight gain, fewer episodes of apnea, decreased use of formula, improved sleep, and decreased crying Populations with a purposeful sample of healthy infants (defined as 3 or more of the following factors: never on oxygen, never on medications, no intraventricular hemorrhage or other perinatal brain injury, Apgar scores >7 at 1 or 5 min, or never had sepsis) A systematic search for studies published from October 2015 to October 2020 was performed using databases including MEDLINE (via PubMed), CINAHL (Cumulative Index to Nursing and Allied Health Literature), the Cochrane Library, and Google Scholar. Reference lists of included studies were also searched.…”

Section: Tactilementioning

confidence: 99%

NICU sensory experiences associated with positive outcomes: an integrative review of evidence from 2015–2020

et al. 2023

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To inform changes to the Supporting and Enhancing NICU Sensory Experiences (SENSE) program, studies investigating sensory-based interventions in the NICU with preterm infants born ≤32 weeks were identified. Studies published between October 2015 to December 2020, and with outcomes related to infant development or parent well-being, were included in this integrative review. The systematic search used databases including MEDLINE, Cumulative Index to Nursing and Allied Health Literature, the Cochrane Library, and Google Scholar. Fifty-seven articles (15 tactile, 9 auditory, 5 visual, 1 gustatory/olfactory, 5 kinesthetic, and 22 multimodal) were identified. The majority of the sensory interventions that were identified within the articles were reported in a previous integrative review (1995–2015) and already included in the SENSE program. New evidence has led to refinements of the SENSE program, notably the addition of position changes across postmenstrual age (PMA) and visual tracking starting at 34 weeks PMA.

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“…Changes in the function of the HPA axis, as the primary stress management system in the body, cause a wide range of stress-related disorders (13). In particular, various molecules, such as hypothalamic-derived neuropeptides, corticotropin-releasing hormone (CRH), and arginine vasopressin, are involved in response to stress, regulating the behavioral response to stress (14). Furthermore, several areas of the brain, such as the hippocampus and amygdala, control the stress response.…”

Section: Association Of Slc6a4 Gene With Hpa Axismentioning

confidence: 99%

Association of the Effect of SLC6A4 Gene Polymorphisms on the Risk of Diabetes‏

Haghighat

Mahmoudi

2022

Gene Cell Tissue

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Context: The SLC6A4 gene encodes the serotonin transporter. Mutations in this gene can lead to various diseases, such as diabetes. Diabetes is one of the most common metabolic disorders with a genetic background. This review study evaluated the role of SLC6A4 gene polymorphisms in the risk of diabetes. Evidence Acquisition: In this review article, a literature search was conducted in scientific databases, including Google Scholar and PubMed, to find studies published within 2000 to 2021 on the role of SLC6A4 gene polymorphisms on the risk of diabetes. Results: Some genetic and environmental factors are involved in the development of diabetes. Additionally, the association between diabetes and disorder in different genes has been investigated in numerous studies. The discovery of these genetic changes in diabetes might shed light on the functional role of genetic mutations in the development of diabetes. Conclusions: Further genomic research is needed to determine the possible role of SLC6A4 gene polymorphisms in diabetes and obesity.

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Delivery room skin-to-skin contact in preterm infants affects long-term expression of stress response genes

Cited by 17 publications

References 46 publications

Skin-to-Skin Contact for Transferring Preterm Infants from the Delivery Room to the Neonatal Intensive Care Unit Is Promising Despite Moderate Heat Loss during the Procedure

Skin-to-Skin Contact for Transferring Preterm Infants from the Delivery Room to the Neonatal Intensive Care Unit Is Promising Despite Moderate Heat Loss during the Procedure

NICU sensory experiences associated with positive outcomes: an integrative review of evidence from 2015–2020

Association of the Effect of SLC6A4 Gene Polymorphisms on the Risk of Diabetes‏

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