Abstract:Mother's awareness of potential obstetric danger signs during pregnancy, child birth and immediate post-delivery are crucial to influence their decisions to seek immediate health care. However, their awareness and health care practice were not well known in Haramaya district. Thus, this study was to assess mother's awareness of obstetric danger signs and their health care seeking practice. Community based cross sectional study was conducted in June, 2012 on 757 mothers who gave birth for the last two years and reside in Haramaya District. Sample size was estimated by using a single population proportions formula. Multistage sampling method was used to select study subjects. Data was collected by interview using structured questionnaires. Bivariate and multivariate were used to analyze predictors. Results: Only 86 (11.3%) of respondents mentioned three and above key obstetric danger signs during pregnancy. About half of 402(53%) of respondents did not aware for at least one obstetric danger signs. 234 (31%) respondents were reported to have experienced one or more key danger signs but 31.2% of them did not sought for medical treatment. Mothers who followed primary education 2.7 times [AOR 2.7; 95% CI 1.5-7.2], and secondary and above education 2.4 times [AOR 2.4; 95% CI 1.3-5.4] more likely to have awareness on obstetric danger signs during pregnancy as compared to those didn't attained formal education. Mothers who attended antenatal care were 4.28 times [AOR 4.28; 95% CI 2.01-9.12] more likely of having awareness on obstetric danger sign than mother who did not attended ANC. Similarly, the odds of giving birth at health institutions increased the level of awareness about obstetric danger signs about three fold [AOR 3.23;] than those who giving birth at home. Conclusion: Awareness of mothers on obstetric danger signs in the study area and health seeking practice were low. Thus, community education and information during antenatal Care utilization, institutional delivery services and postnatal care about obstetric danger signs and its consequence if the mother will not seeking care are important steps in improving the awareness and health seeking practice.