Delivery of twins following heterotopic grafting of frozen-thawed ovarian tissue

Stern, Catharyn; Gook, Debra A.; Hale, Lyndon; Agresta, Franca; Oldham, J. B.; Rozen, Genia; Jobling, Tom

doi:10.1093/humrep/deu119

Cited by 61 publications

(47 citation statements)

References 1 publication

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“…To date worldwide, the only forms of human ovary autotransplantation resulted in healthy live births are cortical ovarian tissue orthotopic transplantation (40 babies) and heterotopic transplantation (2 babies) although an accurate international registry is highly required (Tables 1, 2, and 3) [28-60]. …”

Section: Resultsmentioning

confidence: 99%

“…However, it is a time-consuming method (within several hours) and usually needs a computerized freezing machine [64-71]. To date, several protocols for slow freezing/thawing have been described and at least 39 live births were reported worldwide after slow freezing/thawing of human cortical ovarian tissue (Tables 1 and 2) [28-57, 60]. …”

Section: Resultsmentioning

confidence: 99%

“…To date, this technique has resulted in the first two babies worldwide (Tables 1 and 2) [60]; in addition, it resulted in a four-cell embryo [106], a biochemical pregnancy [107], and a clinical pregnancy [108]. …”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

New advances in ovarian autotransplantation to restore fertility in cancer patients

Salama

Woodruff

2015

Cancer Metastasis Rev

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Human ovary autotransplantation is a promising option for fertility preservation of young women and girls undergoing gonadotoxic treatments for cancer or some autoimmune diseases. Although experimental, it resulted in at least 42 healthy babies worldwide. According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic literature review was performed for all relevant full-text articles published in English from 1 January 2000 to 01 October 2015 in PubMed to explore the latest clinical and research advances of human ovary autotransplantation. Human ovary autotransplantation involves ovarian tissue extraction, freezing/thawing, and transplantation back into the same patient. Three major forms of human ovary autotransplantation exist including (a) transplantation of cortical ovarian tissue, (b) transplantation of whole ovary, and (c) transplantation of ovarian follicles (artificial ovary). According to the recent guidelines, human ovary autotransplantation is still considered experimental; however, it has unique advantages in comparison to other options of female fertility preservation. Human ovary autotransplantation (i) does not need prior ovarian stimulation, (ii) allows immediate initiation of cancer therapy, (iii) can restore both endocrine and reproductive ovarian functions, and (iv) may be the only fertility preservation option suitable for prepubertal girls or for young women with estrogen-sensitive malignancies. As any other fertility preservation option, human ovary autotransplantation has both advantages and disadvantages and may not be feasible for all cases. The major challenges facing this option are how to avoid the risk of reintroducing malignant cells and how to prolong the lifespan of ovarian transplant as well as how to improve artificial ovary results.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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New advances in ovarian autotransplantation to restore fertility in cancer patients

Salama

Woodruff

2015

Cancer Metastasis Rev

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“…Differences in temperature, paracrine factors, and blood supply exist compared with ovaries that are located in the intrapelvic region. Although the restoration of endocrine function has been consistently demonstrated after heterotopic transplantation of cryopreserved ovaries, all except 1 of the 38 deliveries reported in the literature resulted from orthotopic transplantation (17)(18)(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Comparison of markers of ovarian reserve between patients with complete müllerian agenesis and age-matched fertile and infertile controls

Ozekinci

Akar

Şenol

et al. 2015

Fertility and Sterility

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“…Globally, a total of 39 children were born after transplantation of ovarian tissue, although there are still some ongoing pregnancies. There is also data available on 12 births after allogeneic transplantation of fresh ovarian tissue [45,46]. Although orthotopic transplantation of ovarian tissue is considered the standard procedure, as the majority of pregnancies and births have been reported with this technique, a report from Australia last year gave an account of a twin birth after heterotopic transplantation of ovarian tissue and IVF.…”

Section: Cryopreservation Of Ovarian Tissuementioning

confidence: 99%

Fertility Protection in Female Oncology Patients: How Should Patients Be Counseled?

Findeklee

Lotz

Hoffmann

et al. 2015

Geburtshilfe Frauenheilkd

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Protecting the fertility of patients with oncologic disease is becoming more and more important, as fulfilling the wish to have children is increasingly occurring at a later stage in life and long-term survival rates after cancer are continuing to improve. A number of fertility-preserving options exist. In addition to techniques which have been around for some time such as medical ovarian suppression, ovarian transposition, and organ-preserving surgery, there are other, more recent, innovative methods which have developed over the last few years such as cryopreservation of oocytes or ovarian tissue transplantation after completing cancer therapy. As every procedure has its specific advantages and disadvantages, informed patient consent is essential. The physician?s aim must be to select the optimal procedure for each patient. The extent of patients? information about the options to preserve fertility in women with oncologic disease remains limited. One of the main reasons for this is that clinicians are not sure how to inform patients about existing procedures and methods. The aim of this review article is to provide help in clinical practice.

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Delivery of twins following heterotopic grafting of frozen-thawed ovarian tissue

Cited by 61 publications

References 1 publication

New advances in ovarian autotransplantation to restore fertility in cancer patients

New advances in ovarian autotransplantation to restore fertility in cancer patients

Comparison of markers of ovarian reserve between patients with complete müllerian agenesis and age-matched fertile and infertile controls

Fertility Protection in Female Oncology Patients: How Should Patients Be Counseled?

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