Delivery of timolol through artificial membranes and pig stratum corneum

Stamatialis, Dimitrios; Rolevink, Hendrikus H.M.; Koops, G.H.

doi:10.1002/jps.10387

Cited by 8 publications

(4 citation statements)

References 4 publications

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“…The SC was fragile and it was supported by a dialysis membrane (Dialysis-5, Table 1). In a previous study [7], we found no contribution of this membrane to the overall TM permeability. In iontophoresis, current density of 0.5 mA/cm 2 was applied using Ag plate electrode and Ag/AgCl as driving electrodes in the anodal and cathodal compartment, respectively.…”

Section: Methodscontrasting

confidence: 59%

“…The average TM permeability from a liquid solution through pig SC alone is 3.9 ± 0.9 × 10 − 6 cm/s [7]. For PL concentration up to 20% (w/w) and for the Polyflux® or PES-30 high pore size membranes, the TM permeability is much higher than through the SC and we expect that if these systems are applied in combination with pig SC, the TM transdermal system will be SC controlled.…”

Section: Resultsmentioning

confidence: 94%

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Transdermal timolol delivery from a Pluronic gel

Stamatialis

Rolevink

Koops

2006

Journal of Controlled Release

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Section: Methodscontrasting

confidence: 59%

Section: Resultsmentioning

confidence: 94%

Transdermal timolol delivery from a Pluronic gel

Stamatialis

Rolevink

Koops

2006

Journal of Controlled Release

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“…In almost all patches, an artificial membrane is used in direct contact with the skin which should be made of biocompatible material to avoid skin irritation and have low drug adsorption. In recent studies in our group, several membranes have been evaluated in transdermal patches containing TM [44,[54][55][56] and salmon calcitonin (sCT) [57]. Tables 1 and 2 present some results of drug adsorption to commercial membranes [44,57].…”

Section: Iontophoresismentioning

confidence: 99%

Medical applications of membranes: Drug delivery, artificial organs and tissue engineering

Stamatialis

Papenburg

Girones

et al. 2008

Journal of Membrane Science

416

218

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This paper covers the main medical applications of artificial membranes. Specific attention is given to drug delivery systems, artificial organs and tissue engineering which seem to dominate the interest of the membrane community this period. In all cases, the materials, methods and the current state of the art are evaluated and future prospects are discussed. Concerning drug delivery systems, attention is paid to diffusion controlled systems. For the transdermal delivery systems, passive as well as iontophoretic systems are described in more detail. Concerning artificial organs, we cover in detail: artificial kidney, membrane oxygenation, artificial liver, artificial pancreas as well as the application of membranes for tissue engineering scaffolds and bioreactors. This review shows the important role of membrane science and technology in medical applications but also highlights the importance of collaboration of membrane scientists with others (biologists, bioengineers, medical doctors, etc.

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“…Electrically driven transport across multiple membrane or multiple pathway systems is commonly encountered in pharmaceutical devices. For example, synthetic membranes are often used in devices for transdermal iontophoretic drug delivery; the result here is a two‐membrane system involving the synthetic membrane and skin 7. Other investigators control drug release from implants with heterogeneous cation‐exchange membranes8 or enhance transdermal and ocular iontophoretic delivery with ion‐exchange membranes 9, 10.…”

Section: Introductionmentioning

confidence: 99%

Iontophoretic Transport Across a Multiple Membrane System

Molokhia

Zhang

Higuchi

et al. 2008

Journal of Pharmaceutical Sciences

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The objective of the present study was to investigate the iontophoretic transport behavior across multiple membranes of different barrier properties. Spectra/Por ® (SP) and Ionac membranes were the synthetic membranes and sclera was the biomembrane in this model study. The barrier properties of SP membranes were determined individually in passive and iontophoresis transport experiments with tetraethylammonium ion (TEA), chloride ion (Cl), and mannitol as the model permeants. Passive and iontophoretic transport experiments were then conducted with an assembly of SP membranes. The contribution of electroosmosis to iontophoresis was assessed using the mannitol data. Model analysis was performed to study the contribution of diffusion and electromigration to electrotransport across the multiple membrane system. The effects of membrane barrier thickness upon ion-exchange membrane-enhanced iontophoresis were examined with Ionac, SP, and sclera. The present study shows that iontophoretic transport of TEA across the membrane system was related to the thicknesses and permeability coefficients of the membranes and the electromobilities of the permeant across the individual membranes in the assembly. Model analysis suggests significant contribution of diffusion within the membranes across the membrane system, and this mechanism is relatively independent of the current density applied across the system in iontophoresis dominant transport.

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Delivery of timolol through artificial membranes and pig stratum corneum

Cited by 8 publications

References 4 publications

Transdermal timolol delivery from a Pluronic gel

Transdermal timolol delivery from a Pluronic gel

Medical applications of membranes: Drug delivery, artificial organs and tissue engineering

Iontophoretic Transport Across a Multiple Membrane System

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