Delivery of <scp>siRNA</scp> using hyaluronic acid‐guided nanoparticles for downregulation of <scp>CXCR4</scp>

Tunalı, Beste Çağdaş; Çelik, Eda; Yildiran, Fatma Azize Budak; Türk, Mustafa

doi:10.1002/bip.23535

Cited by 5 publications

(3 citation statements)

References 71 publications

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“…Au- and PEI-based couplers, modified with HA and DOX, deliver siRNAs while protecting against degradation and promoting their escape from endosomes. This enables a selective treatment for cancers [ 129 ]. Fan et al developed a nanosystem using HA-AuNRs, to which siRNA against B7-H3 (B7-H3si) and glucose oxidase (GOx) were attached.…”

Section: Research On Polysaccharide-aunps As Drug Delivery Carriersmentioning

confidence: 99%

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Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

Song,

Aipire,

Dilxat

et al. 2024

Pharmaceutics

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Clinical drug administration aims to deliver drugs efficiently and safely to target tissues, organs, and cells, with the objective of enabling their therapeutic effects. Currently, the main approach to enhance a drug’s effectiveness is ensuring its efficient delivery to the intended site. Due to the fact that there are still various drawbacks of traditional drug delivery methods, such as high toxicity and side effects, insufficient drug specificity, poor targeting, and poor pharmacokinetic performance, nanocarriers have emerged as a promising alternative. Nanocarriers possess significant advantages in drug delivery due to their size tunability and surface modifiability. Moreover, nano-drug delivery systems have demonstrated strong potential in terms of prolonging drug circulation time, improving bioavailability, increasing drug retention at the tumor site, decreasing drug resistance, as well as reducing the undesirable side effects of anticancer drugs. Numerous studies have focused on utilizing polysaccharides as nanodelivery carriers, developing delivery systems based on polysaccharides, or exploiting polysaccharides as tumor-targeting ligands to enhance the precision of nanoparticle delivery. These types of investigations have become commonplace in the academic literature. This review aims to elucidate the preparation methods and principles of polysaccharide gold nanocarriers. It also provides an overview of the factors that affect the loading of polysaccharide gold nanocarriers with different kinds of drugs. Additionally, it outlines the strategies employed by polysaccharide gold nanocarriers to improve the delivery efficiency of various drugs. The objective is to provide a reference for further development of research on polysaccharide gold nanodelivery systems.

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Section: Research On Polysaccharide-aunps As Drug Delivery Carriersmentioning

confidence: 99%

“…The surface modification of AuNPs with HA and low molecular weight PEI enables the efficient transport of siRNA. This modified system serves multiple purposes, including gene silencing, photothermal therapy, and chemotherapy, which are vital in breast cancer treatment [ 129 ].…”

Section: Research On Polysaccharide-aunps As Drug Delivery Carriersmentioning

confidence: 99%

Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

Song,

Aipire,

Dilxat

et al. 2024

Pharmaceutics

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“…The effective transport of small interfering RNAs (siRNAs) can be induced with hyaluronic acid receptors and also carriers with low-molecular-weight polyethyleneimine (PEI)-based transport systems. Gold nanoparticles (AuNPs) and their conjugates with PEI and HA ranged from 25 to 690 nm, and CXCR4 gene silencing on the MDA-MB-231 cell line drastically decreased breast cancer progression [171].…”

Section: Nanoparticles As Si-rna Cxcr4 Carriers For Preventing Tumor ...mentioning

confidence: 99%

Nanoparticles and Mesenchymal Stem Cell (MSC) Therapy for Cancer Treatment: Focus on Nanocarriers and a si-RNA CXCR4 Chemokine Blocker as Strategies for Tumor Eradication In Vitro and In Vivo

Merino,

Cabaña-Muñoz

2023

Micromachines

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Mesenchymal stem cells (MSCs) have a high tropism for the hypoxic microenvironment of tumors. The combination of nanoparticles in MSCs decreases tumor growth in vitro as well as in rodent models of cancers in vivo. Covalent conjugation of nanoparticles with the surface of MSCs can significantly increase the drug load delivery in tumor sites. Nanoparticle-based anti-angiogenic systems (gold, silica and silicates, diamond, silver, and copper) prevented tumor growth in vitro. For example, glycolic acid polyconjugates enhance nanoparticle drug delivery and have been reported in human MSCs. Labeling with fluorescent particles (coumarin-6 dye) identified tumor cells using fluorescence emission in tissues; the conjugation of different types of nanoparticles in MSCs ensured success and feasibility by tracking the migration and its intratumor detection using non-invasive imaging techniques. However, the biosafety and efficacy; long-term stability of nanoparticles, and the capacity for drug release must be improved for clinical implementation. In fact, MSCs are vehicles for drug delivery with nanoparticles and also show low toxicity but inefficient accumulation in tumor sites by clearance of reticuloendothelial organs. To solve these problems, the internalization or conjugation of drug-loaded nanoparticles should be improved in MSCs. Finally, CXCR4 may prove to be a promising target for immunotherapy and cancer treatment since the delivery of siRNA to knock down this alpha chemokine receptor or CXCR4 antagonism has been shown to disrupt tumor–stromal interactions.

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