Delivery of repurposed disulfiram by aminated mesoporous silica nanoparticles for anticancer therapy

Aquib, Md; Zhang, Hang; Raza, Faisal; Banerjee, Parikshit; Bavi, Rohit; Kesse, Samuel; Boakye‐Yiadom, Kofi Oti; Filli, Mensura Sied; Farooq, Muhammad Asim; Wang, Bo

doi:10.1016/j.molliq.2021.117065

Cited by 10 publications

(5 citation statements)

References 89 publications

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“…The zeta-potentials of MSN, MSN-NH 2 , and MSN-PEG ( Figure 1C ) were −31.5 ± 0.2, 0.794 ± 0.47, and 9.25 ± 0.48 mV, respectively. Obviously, when MSN was modified by amination, the surface charge changed to positive ( Aquib et al, 2021 ). The change of surface charge of MSN was attributed to the appearance of amino groups in MSN ( Yang et al, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

Photothermal 2D Nanosheets Combined With Astragaloside IV for Antibacterial Properties and Promoting Angiogenesis to Treat Infected Wounds

Liu

Wang

Hong

et al. 2022

Front. Bioeng. Biotechnol.

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Bacterial infection, inflammatory disorder, and poor angiogenesis of tissue in chronic wounds are the main reasons why wounds are difficult to heal. In this study, a novel MSN-PEG@AS/BP nano-spray was designed to solve these issues. Astragaloside IV (AS) was loaded in mesoporous silica nanoparticles (MSN) to enhance angiogenesis and regulate inflammation, and the two-dimensional (2D) nanosheet black phosphorus (BP) was used to kill bacteria through a photothermal effect. Under thermal decomposition, the covalent bond of polyethylene glycol (PEG) was broken, releasing AS to promote the proliferation of fibroblasts, the formation of blood vessels, and the resolution of inflammation. AS can promote the polarization of the anti-inflammatory (M2) macrophage phenotype to enhance the deposition of extracellular matrix and the formation of blood vessels. Besides, BP showed a significant photothermal effect and nearly 99.58% of Escherichia coli and 99.13% of Staphylococcus aureus were killed in an antibacterial study. This nano-spray would be a novel therapeutic agent for infected wound treatment.

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Section: Resultsmentioning

confidence: 99%

Photothermal 2D Nanosheets Combined With Astragaloside IV for Antibacterial Properties and Promoting Angiogenesis to Treat Infected Wounds

Liu

Wang

Hong

et al. 2022

Front. Bioeng. Biotechnol.

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“…Subsequently, additional functional elements, such as Ca 2+ , -S-S-, and PEG, are introduced onto the surface of mesoporous silica to establish a delivery response to pH, GSH, temperature, etc. (see Table 1 ) [ 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ]. In recent years, enhancing therapeutic effects has led to a focus on constructing multifunctional drug delivery platforms.…”

Section: Applications Of Mesoporous Silicamentioning

confidence: 99%

Synthesis of Mesoporous Silica Using the Sol–Gel Approach: Adjusting Architecture and Composition for Novel Applications

Han,

Zhang,

Yang

2024

Nanomaterials

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The sol–gel chemistry of silica has long been used for manipulating the size, shape, and microstructure of mesoporous silica particles. This manipulation is performed in mild conditions through controlling the hydrolysis and condensation of silicon alkoxide. Compared to amorphous silica particles, the preparation of mesoporous silica, such as MCM-41, using the sol–gel approach offers several unique advantages in the fields of catalysis, medicament, and environment, due to its ordered mesoporous structure, high specific surface area, large pore volume, and easily functionalized surface. In this review, our primary focus is on the latest research related to the manipulation of mesoporous silica architectures using the sol–gel approach. We summarize various structures, including hollow, yolk-shell, multi-shelled hollow, Janus, nanotubular, and 2D membrane structures. Additionally, we survey sol–gel strategies involving the introduction of various functional elements onto the surface of mesoporous silica to enhance its performance. Furthermore, we outline the prospects and challenges associated with mesoporous silica featuring different structures and functions in promising applications, such as high-performance catalysis, biomedicine, wastewater treatment, and CO2 capture.

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“…The high contact surface area of nanoparticles yields more interactions between tumor cells and drug particles. 33,34 To be internalized by tumor cells, nanoparticles need to have a size in the range of 50 to 100 nm, have slight surface charges, either positive or negative, and have negligible interactions. 32,35 Nanoparticles that are cationic lead to better interactions between the cells and nanoparticles and improved uptake of drug nanoparticles because the cell membrane is negatively charged, as shown in Fig.…”

Section: Essential Properties Of Paclitaxel Nanomedicinementioning

confidence: 99%

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

et al. 2022

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Delivery of repurposed disulfiram by aminated mesoporous silica nanoparticles for anticancer therapy

Cited by 10 publications

References 89 publications

Photothermal 2D Nanosheets Combined With Astragaloside IV for Antibacterial Properties and Promoting Angiogenesis to Treat Infected Wounds

Photothermal 2D Nanosheets Combined With Astragaloside IV for Antibacterial Properties and Promoting Angiogenesis to Treat Infected Wounds

Synthesis of Mesoporous Silica Using the Sol–Gel Approach: Adjusting Architecture and Composition for Novel Applications

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

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