Delivery of novel vancomycin nanoplexes for combating methicillin resistant Staphylococcus aureus (MRSA) infections

Hassan, Daniel; Omolo, Calvin A.; Gannimani, Ramesh; Waddad, Ayman Y.; Mocktar, Chunderika; Rambharose, Sanjeev; Agrawal, Nikhil

doi:10.1016/j.ijpharm.2019.01.010

Cited by 33 publications

(12 citation statements)

References 66 publications

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“…S. aureus strains isolated from humans, pigs, and cattle have created intermediate resistance to vancomycin [ 92 ]. Vancomycin formulated as nanoplexes of the antibiotic with dextran sulfate sodium salt has recently addressed MRSA infections; the size, polydispersity, and zeta potential of the optimized nanoplexes were 84.6 ± 4.3 nm, 0.449 ± 0.024, and −33.0 ± 4.9 mV, respectively, with 90.4 ± 0.8% complexation efficiency and 62.3 ± 0.2% drug loading; in vivo studies using a BALB/c mouse skin infection model revealed that nanoplexes reduced MRSA burden by 2.3−fold compared to bare vancomycin [ 93 ]. Liposomal vancomycin topical formulations have also produced similar results against MRSA, reconfirming the importance of the formulation for fighting drug−resistant microbia [ 94 ].…”

Section: Asa With Ampsmentioning

confidence: 99%

Antimicrobial Polymer−Based Assemblies: A Review

Carmona-Ribeiro

Araújo

2021

IJMS

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An antimicrobial supramolecular assembly (ASA) is conspicuous in biomedical applications. Among the alternatives to overcome microbial resistance to antibiotics and drugs, ASAs, including antimicrobial peptides (AMPs) and polymers (APs), provide formulations with optimal antimicrobial activity and acceptable toxicity. AMPs and APs have been delivered by a variety of carriers such as nanoparticles, coatings, multilayers, hydrogels, liposomes, nanodisks, lyotropic lipid phases, nanostructured lipid carriers, etc. They have similar mechanisms of action involving adsorption to the cell wall, penetration across the cell membrane, and microbe lysis. APs, however, offer the advantage of cheap synthetic procedures, chemical stability, and improved adsorption (due to multipoint attachment to microbes), as compared to the expensive synthetic routes, poor yield, and subpar in vivo stability seen in AMPs. We review recent advances in polymer−based antimicrobial assemblies involving AMPs and APs.

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Section: Asa With Ampsmentioning

confidence: 99%

Antimicrobial Polymer−Based Assemblies: A Review

Carmona-Ribeiro

Araújo

2021

IJMS

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“…VAN‐loaded liposomes, [ 23 , 24 ] solid lipid nanoparticles, [ 25 ] and polymeric nanoparticles [ 26 ] have been reported to improve the drug accumulation at different sites of infections. Moreover, nanoplexes, [ 27 ] supramolecular self‐assembled drug delivery systems, [ 28 ] and oleic acid nanoparticles [ 29 ] have been successfully employed for improved treatment of MRSA‐caused skin infections in vivo. Intradermal delivery of VAN in vivo has been reported in mediastinitis [ 30 ] by incorporating it in nanoscale phospholipid bilayers containing ethanol combined with iontophoresis.…”

Section: Introductionmentioning

confidence: 99%

Vancomycin‐Loaded Microneedle Arrays against Methicillin‐Resistant Staphylococcus Aureus Skin Infections

Ziesmer

Tajpara

Hempel

et al. 2021

Adv Materials Technologies

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Skin and soft tissue infections (SSTIs) caused by methicillin‐resistant Staphylococcus aureus (MRSA) are a major healthcare burden, often treated with intravenous injection of the glycopeptide antibiotic vancomycin (VAN). However, low local drug concentration in the skin limits its treatment efficiency, while systemic exposure promotes the development of resistant bacterial strains. Topical administration of VAN on skin is ineffective as its high molecular weight prohibits transdermal penetration. In order to implement a local VAN delivery, microneedle (MN) arrays with a water‐insoluble support layer for the controlled administration of VAN into the skin are developed. The utilization of such a support layer results in water‐insoluble needle shafts surrounded by drug‐loaded water‐soluble tips with high drug encapsulation. The developed MN arrays can penetrate the dermal barriers of both porcine and fresh human skin. Permeation studies on porcine skin reveal that the majority of the delivered VAN is retained within the skin. It is shown that the VAN‐MN array reduces MRSA growth both in vitro and ex vivo on skin. The developed VAN‐MN arrays may be extended to several drugs and may facilitate localized treatment of MRSA‐caused skin infections while minimizing adverse systemic effects.

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“…Micro-and nano-carrier systems are among the approaches that have been successfully utilized for encapsulation of various types of drugs such as peptides, proteins, and low-molecular weight drugs [3][4][5]. These systems have been found to overcome limitations of conventional dosages forms such as improving solubility [6], bioavailability, and biodistribution of drugs [7], and targeting disease sites [8], hence contributing to a high proportion of the active drug reaching the targeted site.…”

Section: Introductionmentioning

confidence: 99%

Nano/Microparticles Encapsulation Via Covalent Drug Conjugation

Fasiku¹,

Amuhaya²,

Kingo³

et al. 2021

Nano- And Microencapsulation - Techniques and Applications

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Advancement in chemistry holds a great promise in improving drug encapsulation that leads to superior drug delivery efficiency and the therapeutic efficacy of nano/micro-delivery systems. Drugs are being designed to specifically access the infection sites via covalent conjugation to nano/micro-delivery systems. This chapter focuses on techniques for achieving covalent encapsulation of drugs in nano/micro-delivery systems, how conjugation is applied to selectively influence pharmacokinetic profile, intracellular, and extracellular uptake, specific targeting to disease sites, binding to specific receptors, and controlled/sustained release. In addition, the effect of conjugation on drug efficacy and biosafety of the micro/ nanoparticulate drug delivery systems are discussed.

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Delivery of novel vancomycin nanoplexes for combating methicillin resistant Staphylococcus aureus (MRSA) infections

Cited by 33 publications

References 66 publications

Antimicrobial Polymer−Based Assemblies: A Review

Antimicrobial Polymer−Based Assemblies: A Review

Vancomycin‐Loaded Microneedle Arrays against Methicillin‐Resistant Staphylococcus Aureus Skin Infections

Nano/Microparticles Encapsulation Via Covalent Drug Conjugation

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