Delivery of novel coumarin–dihydropyrimidinone conjugates through mixed polymeric nanoparticles to potentiate therapeutic efficacy against triple-negative breast cancer

Abstract

Till date most of the accessible therapeutic options are virtually non-responsive towards Triple-negative breast cancer (TNBC) due to their highly aggressive and metastatic nature. Interestingly, chemotherapy reacts soundly in many...

PEG-4000 formed polymeric nanoparticles loaded with cetuximab downregulate p21 & stathmin-1 gene expression in cancer cell lines

“…The advantage of using PEGNPs is that the carriers keep the drugs and additional biologically active fragments protected from the environment and increase the bioavailability and therapeutic index of the drugs [8,9]. It was reported that a coumarin-dihydropyrimidinone formulated in poly(lactic-co-glycolic acid) (PLGA)-PEG 4000 mixed copolymer nanoparticles showed excellent therapeutic effect on a wide variability of cancer cell lines [10].…”