“…The advantage of using PEGNPs is that the carriers keep the drugs and additional biologically active fragments protected from the environment and increase the bioavailability and therapeutic index of the drugs [8,9]. It was reported that a coumarin-dihydropyrimidinone formulated in poly(lactic-co-glycolic acid) (PLGA)-PEG 4000 mixed copolymer nanoparticles showed excellent therapeutic effect on a wide variability of cancer cell lines [10].…”