Delivery of drug macromolecules from thermally responsive gel implants to the posterior eye

Ninawe, Pravin R.; Hatziavramidis, Dimitri; Parulekar, Satish J.

doi:10.1016/j.ces.2010.06.014

Cited by 17 publications

(12 citation statements)

References 18 publications

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“…21 Recently, a great deal of attention has been devoted to multicomponent supramolecular gels. 7,8,12 In this case, the use of supramolecular gels responsive to different pH and temperature conditions or enzymatic action could favour the release of active molecules within the target organ. 19,22,23 Furthermore, most of gel phase applications are based on twocomponent gels.…”

Section: Introductionmentioning

confidence: 99%

Organic salts and aromatic substrates in two-component gel phase formation: the study of properties and release processes

et al. 2015

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To identify gel phases able to act as confined reaction media or materials for the removal of organic pollutants, we studied two-component gel phases formed by naphthalenedisulfonate diimidazolium salts in the presence of some organic guests, in 1-propanol solution. Guests differing in π-surface area, bulkiness and electronic properties were taken into account. Soft materials obtained were investigated for their thermal stability, self-repairing ability and morphology. Furthermore, two-component gel phase formation was studied using resonance light scattering (RLS) measurements. Guest release processes from the gel phase were also studied. These processes were monitored as a function of time using both UV-vis and RLS measurements and considering important parameters such as the gelator concentration, the nature of extraction solvent and the extension of contact surface area between solvent and gel phase. Data collected shed light on the properties of the two-component gels and could represent a useful tool to better plan the application of these soft materials.

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Section: Introductionmentioning

confidence: 99%

Organic salts and aromatic substrates in two-component gel phase formation: the study of properties and release processes

et al. 2015

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“…Unless mentioned otherwise, the values of key parameters listed in Table 1 were used to obtain the results presented and discussed next. These parameters are representative of immunoglobulin G (IgG) (drug, molecular mass ¼ 150 kDa) and PNIPAAm gel, which has LCST of 32 C. 37,[42][43][44] The drug and the hydrogel have been popular candidates in prior experimental investigations.…”

Section: Resultsmentioning

confidence: 99%

“…In compartmental models reported in biomedical engineering and pharmacokinetics literature, however, it is a common practice to consider the surrounding tissue to be equivalent to a well-mixed region. 36,37 Hydrogel cylinders suspended in a well-mixed solution is a popular setting for laboratory drug delivery studies. 1,5,17,25 Network displacement during hydrogel swelling and deswelling…”

Section: Problem Formulationmentioning

confidence: 99%

Drug loading into and drug release from pH‐ and temperature‐responsive cylindrical hydrogels

Ninawe

Parulekar

2011

Biotechnology Progress

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Hydrogels that undergo deformation upon appropriate changes in pH or temperature have considerable promise as drug delivery vehicles. Drug uptake in swelling and nonswelling cylindrical hydrogels and drug release from these into a target fluid are investigated here. A mathematical model for hydrogel-solution composite, a composite of a distributed parameter system (cylindrical hydrogel) and a lumped parameter system (surrounding solution), is developed. The polymer network displacement in a swelling/deswelling hydrogel is described by a stress diffusion coupling model. The analytical solution for network displacement is used to predict solvent intake by swelling hydrogels, solvent efflux from deswelling hydrogels, and changes in pressure, porosity, and effective drug diffusivity. These in turn influence drug uptake during and after hydrogel swelling and drug release from hydrogel during and after deswelling. Numerical results illustrate benefits of hydrogel swelling for drug loading and merits of different modes of drug release. Drug uptake and drug release by temperature-responsive hydrogels are compared with those by hydrogels not subject to deformation.

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“…Responsive hydrogels are especially good for sustained delivery of proteins and peptides as their aqueous environment is able to protect these fragile drugs [44]. An example of investigated responsive delivery of proteins is a poly( N -isopolyacrylamide) (NIPAM)-based implantable hydrogel designed by Ninawe and colleagues [45]. In this study NIPAM with LCST of 32 °C was used as the temperature responsive gelling polymer and a model protein immunoglobulin G (IgG) was loaded into the gel for delivery to the posterior segment of the eye via implantation in the sclera as the treatment of age-related macular degeneration (AMD).…”

Section: Responsive Protein and Peptide Deliverymentioning

confidence: 99%

Stimuli-Responsive Polymeric Systems for Controlled Protein and Peptide Delivery: Future Implications for Ocular Delivery

et al. 2016

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Therapeutic proteins and peptides have become notable in the drug delivery arena for their compatibility with the human body as well as their high potency. However, their biocompatibility and high potency does not negate the existence of challenges resulting from physicochemical properties of proteins and peptides, including large size, short half-life, capability to provoke immune responses and susceptibility to degradation. Various delivery routes and delivery systems have been utilized to improve bioavailability, patient acceptability and reduce biodegradation. The ocular route remains of great interest, particularly for responsive delivery of macromolecules due to the anatomy and physiology of the eye that makes it a sensitive and complex environment. Research in this field is slowly gaining attention as this could be the breakthrough in ocular drug delivery of macromolecules. This work reviews stimuli-responsive polymeric delivery systems, their use in the delivery of therapeutic proteins and peptides as well as examples of proteins and peptides used in the treatment of ocular disorders. Stimuli reviewed include pH, temperature, enzymes, light, ultrasound and magnetic field. In addition, it discusses the current progress in responsive ocular drug delivery. Furthermore, it explores future prospects in the use of stimuli-responsive polymers for ocular delivery of proteins and peptides. Stimuli-responsive polymers offer great potential in improving the delivery of ocular therapeutics, therefore there is a need to consider them in order to guarantee a local, sustained and ideal delivery of ocular proteins and peptides, evading tissue invasion and systemic side-effects.

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Delivery of drug macromolecules from thermally responsive gel implants to the posterior eye

Cited by 17 publications

References 18 publications

Organic salts and aromatic substrates in two-component gel phase formation: the study of properties and release processes

Organic salts and aromatic substrates in two-component gel phase formation: the study of properties and release processes

Drug loading into and drug release from pH‐ and temperature‐responsive cylindrical hydrogels

Stimuli-Responsive Polymeric Systems for Controlled Protein and Peptide Delivery: Future Implications for Ocular Delivery

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