Delivery of doxorubicin in vitro and in vivo using bio-reductive cellulose nanogels

Hu, Qian; Wang, Xin; Yuan, Kangjun; Xie, Chen; Wu, Wei; Jiang, Xiqun; Hu, Lijiang

doi:10.1039/c3bm60176e

Cited by 62 publications

(25 citation statements)

References 41 publications

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“…For example, only~10% of the loaded DOX is released within 240 h, suggesting that DOX release from the nanogels in neutral environment is significantly suppressed. This release behavior is well consistent with previous work [22]. However, when the medium pH decreases to 5.5, the release of DOX is still very slow.…”

Section: Drug Loading and Release Of Hep Nanogelssupporting

confidence: 91%

Bioreducible heparin-based nanogel drug delivery system

Yao

Wang

et al. 2015

Biomaterials

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Section: Drug Loading and Release Of Hep Nanogelssupporting

confidence: 91%

Bioreducible heparin-based nanogel drug delivery system

Yao

Wang

et al. 2015

Biomaterials

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“…Subsequently, the cross-linked carboxymethyl cellulose-g-poly(acrylic acid) (CMC-g-PAA) was synthesized by copolymerization of methacrylated carboxymethyl cellulose with acrylic acid in the presence of potassium persulfate. According to previous reports, the degree of methacrylation modification on carboxymethyl cellulose was over 11% [19]. From the calculation, the graft content of CMC-g-PAA was beyond 88%, and more obvious than that for most similar cellulose-based copolymers reported by others [20,21].…”

Section: Characterization Of Cmc-g-paamentioning

confidence: 54%

Synthesis of Poly(acrylic acid)-Grafted Carboxymethyl Cellulose for Efficient Removal of Copper Ions

Lin¹,

Cao²,

Song³

et al. 2019

Journal of Renewable Materials

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Biocompatible and high content grafted carboxymethyl cellulose-gpoly(acrylic acid) powder was successfully synthesized in an aqueous system, and used as adsorbents for the removal of Cu(II) in aqueous solution. The copolymer was characterized by FT-IR and SEM techniques. Graft copolymerization introduced a large number of carboxyl groups in the polymer and caused the micro-surface of the material to be porous. The fundamental adsorption behaviors of the material were studied. The adsorption kinetics was well fitted with pseudo-second order equation, while the adsorption isotherm preferred to be described the Langmuir equation. The maximum adsorption capacity obtained from the Langmuir model was 154.32 mg/g, indicating that the adsorption capacity of carboxymethyl cellulose was improved remarkably after grafting poly(acrylic acid). Moreover, Fourier transform infrared spectroscopy (FT-IR) has been used to investigate the adsorption mechanisms at molecular levels, which revealed that carboxyl groups are facile to form bidentate carboxylates with metal ions. Thus, this environment friendly copolymer will be a promising candidate for application in removal of heavy metal ions.

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“…The crosslinkers may have bi-functional or multi-functional groups, and the nanogels can be crosslinked via covalent bonds [ 48 ], supramolecular interactions [ 49 ], π–π stacking [ 50 ] and electrostatic interactions [ 51 ]. In addition, some crosslinkers contain environmentally responsive moieties such as disulfide bonds, endowing nanogels with responsiveness [ 52 ]. As pure inorganic nanoparticles may have poor biocompatibility and be unstable in physiological conditions, coating biocompatible organic macromolecules onto their surface is a rational choice to enhance the stability and biocompatibility ( Figure 1 b).…”

Section: Preparation Of Crosslinked Nanogelsmentioning

confidence: 99%

Recent Advances in Crosslinked Nanogel for Multimodal Imaging and Cancer Therapy

Zhou

Yang

et al. 2020

Polymers

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Nanomaterials have been widely applied in the field of cancer imaging and therapy. However, conventional nanoparticles including micelles and liposomes may suffer the issue of dissociation in the circulation. In contrast, crosslinked nanogels the structures of which are covalently crosslinked have better physiological stability than micelles and liposomes, making them more suitable for cancer theranostics. In this review, we summarize recent advances in crosslinked nanogels for cancer imaging and therapy. The applications of nanogels in drug and gene delivery as well as development of novel cancer therapeutic methods are first introduced, followed by the introduction of applications in optical and multimodal imaging, and imaging-guided cancer therapy. The conclusion and future direction in this field are discussed at the end of this review.

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Delivery of doxorubicin in vitro and in vivo using bio-reductive cellulose nanogels

Cited by 62 publications

References 41 publications

Bioreducible heparin-based nanogel drug delivery system

Bioreducible heparin-based nanogel drug delivery system

Synthesis of Poly(acrylic acid)-Grafted Carboxymethyl Cellulose for Efficient Removal of Copper Ions

Recent Advances in Crosslinked Nanogel for Multimodal Imaging and Cancer Therapy

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