Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance

Zhang, Xu; Zhu, Yanfei; Fan, Lihong; Ling, Junhong; Yang, Li‐Ye; Wang, Nan; Ouyang, Xiaolong

doi:10.1016/j.ijbiomac.2022.05.086

Cited by 28 publications

(12 citation statements)

References 64 publications

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“…Next, 2 g of CTAC was dissolved in 20 mL of deionized water, and 0.32 mL of TEA was dropped into the solution, followed by stirring at 95 • C for 1 h. TEOS (1.5 mL) was then added slowly into the solution. The reaction was completed after 1 h. The products were washed with deionized water and ethanol three times, vacuum-dried at −60 • C, and calcined in a Muffle furnace at 550 • C for 6 h to remove the template and obtain MSN-3 [45].…”

Section: Preparation Of Msnsmentioning

confidence: 99%

Efficient Delivery of Curcumin by Alginate Oligosaccharide Coated Aminated Mesoporous Silica Nanoparticles and In Vitro Anticancer Activity against Colon Cancer Cells

et al. 2022

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We designed and synthesized aminated mesoporous silica (MSN-NH2), and functionally grafted alginate oligosaccharides (AOS) on its surface to get MSN-NH2-AOS nanoparticles as a delivery vehicle for the fat-soluble model drug curcumin (Cur). Dynamic light scattering, thermogravimetric analysis, and X-ray photoelectron spectroscopy were used to characterize the structure and performance of MSN-NH2-AOS. The nano-MSN-NH2-AOS preparation process was optimized, and the drug loading and encapsulation efficiencies of nano-MSN-NH2-AOS were investigated. The encapsulation efficiency of the MSN-NH2-Cur-AOS nanoparticles was up to 91.24 ± 1.23%. The pH-sensitive AOS coating made the total release rate of Cur only 28.9 ± 1.6% under neutral conditions and 67.5 ± 1% under acidic conditions. According to the results of in vitro anti-tumor studies conducted by MTT and cellular uptake assays, the MSN-NH2-Cur-AOS nanoparticles were more easily absorbed by colon cancer cells than free Cur, achieving a high tumor cell targeting efficiency. Moreover, when the concentration of Cur reached 50 μg/mL, MSN-NH2-Cur-AOS nanoparticles showed strong cytotoxicity against tumor cells, indicating that MSN-NH2-AOS might be a promising tool as a novel fat-soluble anticancer drug carrier.

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Section: Preparation Of Msnsmentioning

confidence: 99%

Efficient Delivery of Curcumin by Alginate Oligosaccharide Coated Aminated Mesoporous Silica Nanoparticles and In Vitro Anticancer Activity against Colon Cancer Cells

et al. 2022

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“…17−20 Moreover, it has been described to be a mediator of enhanced drug-loading capacity into mesoporous SiNPs. 21,22 Considering the above-mentioned biologically relevant characteristics of SiNPs, sulfates/sulfonic moieties, GAGs, and fucoidan, we combined them and developed bioactive SiNPs coated with fucoidan (a mimic of the sulfated GAGs) or functionalized with sulfonic groups (−SO 3 H) and evaluated their ability to induce the osteogenic differentiation of bmMSCs.…”

Section: Introductionmentioning

confidence: 99%

“…. It has also been recently reported that its low-molecular-weight (<30 kDa) fraction is able to promote osteogenic differentiation. − Moreover, it has been described to be a mediator of enhanced drug-loading capacity into mesoporous SiNPs. , …”

Section: Introductionmentioning

confidence: 99%

Fucoidan-Coated Silica Nanoparticles Promote the Differentiation of Human Mesenchymal Stem Cells into the Osteogenic Lineage

Amorim

Dudik

Costa

et al. 2023

ACS Biomater. Sci. Eng.

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Silica nanoparticles (SiNPs) are widely used in biomedical applications, such as cancer therapy/diagnosis or tissue engineering and regenerative medicine. Herein, we synthesized SiNPs and modified them with sulfonic acid groups (by organosilylation followed by oxidation) or a sulfated polysaccharide (i.e., fucoidan, a seaweed biopolymer, by using electrostatic surface immobilization) due to the known capacity of the sulfonic/sulfate moieties to stabilize proteins and promote stem cell differentiation toward the osteogenic lineage. The developed pristine and functionalized nanoparticles were characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS), showing the monodisperse size distribution (between 360 and 450 nm) and the success of the coating/functionalization with fucoidan or sulfonic groups. The developed SiNPs (at a concentration of 50 μg/mL) were assessed through their contact with SaOs2 cells evidencing their cytocompatibility. Furthermore, the osteogenic differentiation of bmMSCs was evaluated by the quantification of ALP activity, as well as the expression profile of osteogenic-related genes, such as Runx2, ALP, and OP. We found that the coating of the SiNPs with fucoidan induced the osteogenic differentiation of bmMSCs, being an effective mediator of bone regeneration.

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“…[14][15][16] In particular, MBG can be used as a good drug carrier for many active monomers in Chinese medicine, and it was found that slow release could be achieved through loading of drugs onto the surface and mesoporous structure, such as curcumin, icariin (ICA), and naringin (NG). [17][18][19] Moreover, NG loading into MBG particles could achieve slow release and improve bioavailability, but studies on NG to promote bone repair by modulating the local bone immune microenvironment are scarce.…”

Section: Introductionmentioning

confidence: 99%

Direct osteogenesis and immunomodulation dual function via sustained release of naringin from the polymer scaffold

Xiong,

Yuan,

Huang

et al. 2023

J. Mater. Chem. B

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Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance

Cited by 28 publications

References 64 publications

Efficient Delivery of Curcumin by Alginate Oligosaccharide Coated Aminated Mesoporous Silica Nanoparticles and In Vitro Anticancer Activity against Colon Cancer Cells

Efficient Delivery of Curcumin by Alginate Oligosaccharide Coated Aminated Mesoporous Silica Nanoparticles and In Vitro Anticancer Activity against Colon Cancer Cells

Fucoidan-Coated Silica Nanoparticles Promote the Differentiation of Human Mesenchymal Stem Cells into the Osteogenic Lineage

Direct osteogenesis and immunomodulation dual function via sustained release of naringin from the polymer scaffold

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