Delivery of Chlorambucil to the Brain Using Surface Modified Solid Lipid Nanoparticles
Swagata Patra,
Joykrishna Dey,
Somnath Kar
et al.
Abstract:The delivery of drugs to the brain in the therapy of diseases of the central nervous system (CNS) remains a continuing challenge because of the lack of delivery systems that can cross the blood-brain barrier (BBB). Therefore, there is a need to develop an innovative delivery method for the treatment of CNS diseases. Thus, we have investigated the interaction of γ-aminobutyric acid (GABA) and S-(−)-γ-amino-α-hydroxybutyric acid (GAHBA) with the GABA receptor by performing a docking study. Both GABA and GAHBA sh… Show more
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