Delivery LL37 by chitosan nanoparticles for enhanced antibacterial and antibiofilm efficacy

Advances of Antimicrobial Peptide‐Based Biomaterials for the Treatment of Bacterial Infections

“…Newly designed or optimized AMP-based biomaterials based on this database may be more prone to exhibit improved in vivo therapeutic efficacy. [85,146] To conclude, the stability and in vivo therapeutic efficacy data of AMP-based biomaterials should be emphasized in future research. Additionally, while striving to develop novel AMPbiomaterial-based bacteriostatic agents, the inherent structures and functions of AMPs and biomaterials should be considered, and parameters need to be tuned to obtain the best performance of the combination.…”

“…Newly designed or optimized AMP‐based biomaterials based on this database may be more prone to exhibit improved in vivo therapeutic efficacy. [ 85,146 ]…”

“…Furthermore, this delivery system has a prolonged half‐life. [ 85 ] Similarly, one study coupled chitosan nanoparticles (CNs) to the AMP microprotein J25 (MccJ25). It was demonstrated that the modified coupling compounds were highly active against gram‐negative and gram‐positive bacteria and had stable activity in various thermal and pH conditions.…”

Non-coding RNA in SARS-CoV-2: Progress toward therapeutic significance

“…Nitric oxide (NO) nanoparticles have been shown to prevent SARS-CoV infection and virulence by providing NO for endothelial cells and inhibiting RNA replication with peroxynitrite residue derived from NO [98] . AuNPs and other similar nanomaterials could be used to bind to coronavirus and, through infrared light emission, obstruct its structure, resulting in the deactivation of the virus [99] , [100] . Along with the antiviral properties, NPs offer a stable delivery system for unstable therapeutics such as microRNAs (miR, miRNA) that are otherwise unstable.…”

Biological activity of lyophilized chitosan scaffolds with inclusion of chitosan and zinc oxide nanoparticles

“…In formulation F2, there is a faster reabsorption and degradation of the material, possibly caused by increased hydrophilicity. This can be explained by the presence of ZnO NPs, which are also rich in -OH groups on their surface besides being biocompatible 87. In formulation F3, the incorporation of NPs-CS results in more controlled degradation and resorption of the scaffold because NPs-CS might act as initiation sites for degradation, affecting the rate at which enzymes, other agents, and biological factors such as lymphocytes, macrophages, and broblasts can access to break down the material and deposit the temporary matrix of connective tissue 88.…”