Delivering modern anticancer therapies in low‐ and middle‐income settings: We can be evidence based

Davidson, Alan; Howard, Scott C.

doi:10.1002/pbc.27347

Cited by 6 publications

(4 citation statements)

References 11 publications

(17 reference statements)

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“…This should then be followed by a systematic evaluation of the results and its publication in peer‐reviewed journals such as this one. Resource‐limited circumstances need not translate into less rigor in patient care and clinical research 56,57 . Pediatric AML is potentially curable with conventional chemotherapy in most patients.…”

Section: Discussionmentioning

confidence: 99%

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SIOP PODC adapted risk stratification and treatment guidelines: Recommendations for acute myeloid leukemia in resource‐limited settings

Bansal

Davidson

Supriyadi

et al. 2019

Pediatric Blood & Cancer

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In low‐ and middle‐income countries (LMICs), limited resources, suboptimal risk stratification, and disproportionate patient‐to‐infrastructure ratio result in low survival of patients with acute myeloid leukemia (AML). A high incidence of relapse, inherent to the biology, renders management arduous. The challenge of treating AML in LMICs is of balancing the intensity of myelosuppressive chemotherapy, which appears necessary for cure, with available supportive care, which influences treatment‐related mortality. The recommendations outlined in this paper are based on published evidence and expert opinion. The principle of this adapted protocol is to tailor treatment to available resources, reduce preventable toxic death, and direct limited resources toward those children who are most likely to be cured.

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Section: Discussionmentioning

confidence: 99%

“…Resourcelimited circumstances need not translate into less rigor in patient care and clinical research. 56,57 Pediatric AML is potentially curable with conventional chemotherapy in most patients. Our aim is for these treatment guidelines to contribute to improved outcomes for children and adolescents with AML in resource-limited settings.…”

Section: Discussionmentioning

confidence: 99%

SIOP PODC adapted risk stratification and treatment guidelines: Recommendations for acute myeloid leukemia in resource‐limited settings

Bansal

Davidson

Supriyadi

et al. 2019

Pediatric Blood & Cancer

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“…SUCCOUR is a comprehensive, inclusive project led by doctors and nurses to promote improvements in supportive care. It builds on the lessons learnt from the Collaborative WT Africa Network with step-by-step development and implementation of simple, effective and cost-effective supportive care interventions, giving priority to those with the highest expected impact on child survival [15, 16] (Figure 1). Each site first conducts a baseline evaluation of current practises and outcomes in several areas of supportive care such as febrile neutropenia, nutrition, abandonment and the use of traditional medicine.…”

Section: Progress In Optimising Management Of the Most Curable Childhmentioning

confidence: 99%

“…A recent study from Chandigarh, India, used methotrexate 5 g/m 2 for children with acute lymphoblastic leukaemia (ALL) in a setting where they could not measure methotrexate levels. Using extra hydration, close monitoring and frequent checks of urine pH and creatinine, they delivered 100 courses of HDMTX without worrisome toxicities [16, 17].…”

Section: Progress In Optimising Management Of the Most Curable Childhmentioning

confidence: 99%

Highlights from the 13th African Continental Meeting of the International Society of Paediatric Oncology (SIOP), 6–9 March 2019, Cairo, Egypt

Khalek

Afungchwi

Beltagy

et al. 2019

ecancer

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The 13th African continental meeting of the international society of paediatric oncology, held on 6–9 March 2019 in Cairo, was organised in collaboration with the Children Cancer Hospital (57357) in Egypt and the global parents’ organisation (Childhood Cancer International) and supported by a large international faculty. With 629 delegates from 37 countries (24 African), this was the largest forum of healthcare professionals focused on children and young people with cancer in Africa to showcase advances and discuss further improvements. Three targeted workshops, on nursing care, pharmacy and nutrition, attracted large numbers and catalysed new collaborative initiatives in supportive care studies, extended roles for pharmacists in quality control and care delivery and addressed malnutrition concurrently with cancer treatment. The Collaborative Wilms Tumour Africa Project, open in seven sub-Saharan countries, and the trials in Burkitt’s lymphoma reported encouraging outcomes with further initiatives in supportive care (the supportive care for children with cancer in Africa project). While acknowledging deficits in radiotherapy provision, available in only 23 of 52 African countries, centres with facilities reported their technical advances that benefit patients. Of great importance for children with brain tumours, who are underdiagnosed in Africa, was the first announcement of African paediatric neuro-oncology society, whose 63 current members aim to tackle the shortage of neurosurgeons through training fellowships, workshops and a dedicated conference. The congress provided the opportunity to discuss how African countries will work with the WHO global initiative aiming to improve childhood cancer survival to 60% in all countries by 2030. This conference report is dedicated to the three Kenyan delegates who died tragically on the Ethiopian Airlines flight ET302 on their way home, full of new ideas and pride in what they had achieved so far. All those who heard their presentations are determined to continue their excellent work to improve cancer care for children in Africa.

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Tumour lysis syndrome

Howard,

Avagyan,

Workeneh

et al. 2024

Nat Rev Dis Primers

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Delivering modern anticancer therapies in low‐ and middle‐income settings: We can be evidence based

Cited by 6 publications

References 11 publications

SIOP PODC adapted risk stratification and treatment guidelines: Recommendations for acute myeloid leukemia in resource‐limited settings

SIOP PODC adapted risk stratification and treatment guidelines: Recommendations for acute myeloid leukemia in resource‐limited settings

Highlights from the 13th African Continental Meeting of the International Society of Paediatric Oncology (SIOP), 6–9 March 2019, Cairo, Egypt

Tumour lysis syndrome

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