Delivering biotherapeutics – technical opportunities and strategic trends

Shohet, Simon; Wood, Gemma

doi:10.1057/palgrave.jcb.3040008

Cited by 2 publications

(2 citation statements)

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“…The inert polymer protects drugs from degradation [102] Gagomeric microparticles Insulin Preclinical Targeting to the intestinal mucosa using mucoadhesive hyaluronan [103,104] Microparticles coacervated with gelatin Heparin Preclinical Complex coacervation compensates the strong negative charge of drugs [105] BEODAS: Bio-erodible enhanced oral drug absorption system; CS/g-PGA: Chitosan and poly(g-glutamic acid); HDV-I: Hepatic-directed vesicle insulin.…”

Section: Preclinical Preclinicalmentioning

confidence: 99%

“…Nanoparticles prepared with biodegradable poly-"-caprolactone and nondegradable positively charged Eudragit RL facilitated the oral absorption of loaded heparin in rabbits [101]. In addition, oral formulation of LMWH was also investigated by the bio-erodible enhanced oral drug absorption system (BEODAS; Elan Corp PLC, Dublin, Ireland) [102]. BEODAS can be achieved through the entrapment of LMWH in a range of sub-micrometer sizes within a biodegradable polymer matrix.…”

Section: Particulate Systemmentioning

confidence: 99%

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Advances in oral macromolecular drug delivery

Hwang

Byun

2014

Expert Opinion on Drug Delivery

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According to the better understanding of receptor or transporter structure and transport mechanisms in the GI tract, the progress ineffective oral delivery systems for therapeutic macromolecules is anticipated over the next decades. In addition, the advent of numerous particulate systems will also speed up the development of novel drug delivery technologies. This offers an optimistic perspective on the potential clinical usage of oral macromolecular drugs.

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