Delirium in the Intensive Care Unit: Occurrence and Clinical Course in Older Patients

McNicoll, Lynn; Pisani, Margaret A.; Zhang, Ying; Ely, E. Wesley; Siegel, Mark D.; Inouye, Sharon K.

doi:10.1034/j.1600-0579.2003.00201.x

Cited by 498 publications

(306 citation statements)

References 36 publications

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“…Delirium, a transient cognitive dysfunction, can result in increased morbidity, higher 6-month mortality, delayed functional recovery, and prolonged hospital stay in intensive care unit (ICU) patients [1][2][3]. Delirium has an incidence ranging between 5% and 50% [4].…”

mentioning

confidence: 99%

EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit

Plaschke

Hill²,

Engelhardt

et al. 2007

Anaesthesia

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SummaryThe aim of this study was to examine whether serum anticholinergic activity (SAA) is a reliable indicator of delirium in the ICU, and whether there is a significant correlation between SAA and quantitative electroencephalographic (EEG) data in delirious patients. In a prospective cohort study, we assessed ICU patients diagnosed with delirium (n = 37). EEG measurements and blood analysis including SAA were performed 48 h following ICU admission. The presence of delirium was evaluated using the Confusion Assessment Method for critically ill patients in ICU (CAM-ICU). The SAA level was measured using a competitive radioreceptor binding assay for muscarinergic receptors and quantitative EEG was measured using the CATEEM Ò system. We found that, under comparable conditions, patients in the delirium group showed a higher relative EEG theta power and a reduced alpha power (n = 17) than did the non-delirious patients (n = 20). No difference in measured SAA levels were seen; therefore, there was no correlation between SAA and EEG measurements in delirious patients. We conclude that, in contrast to the EEG, the SAA level cannot be proposed as a tool for diagnosing delirium in ICU patients.

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mentioning

confidence: 99%

EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit

Plaschke

Hill²,

Engelhardt

et al. 2007

Anaesthesia

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“…Predispozan faktörler arasında ileri yaş, erkek cinsiyet, önceden var olan kognitif bozukluk ve demans, zayıf fonksiyonel kapasite, malnütrisyon, madde ve alkol bağımlılığı, eşlik eden medikal bozukluk, primer nörolojik hastalıklar, enfeksiyon, şok, hipoksi, elektrolit bozuklukları, cerrahi, bazı ilaçlar yer almaktadır (2)(3)(4). Tanı konulamadığı ve tedavi edilemediği takdirde hastane yatış süresinde uzama, işlevsellikte bozulma, mortalite ve morbidite oranlarında artışa neden olmaktadır (5,6).…”

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Effect of Magnesium Level to the Development of Delirium in Patients Under Sedation in Intensive Care Unit

Aslan¹,

Şentürk²,

Özcan³

et al. 2015

tybdd

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“…Critical care areas, for which high rates have been reported, (40) were not included because of the potentially negative impact on the patients in these areas. Emergency departments, which have prevalence rates of approximately 10%, (41,42) were also excluded.…”

Section: Limitationsmentioning

confidence: 99%

A Quality Assurance Study to Assess the One-Day Prevalence of Delirium in Elderly Hospitalized Patients

et al. 2012

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BackgroundResearch indicates that 40% of hospital-acquired delirium cases may be preventable. However, despite its clinical significance, delirium often goes unrecognized or is misdiagnosed. The purpose of this study was to assess the need for delirium education in acute care hospitals in Hamilton, Ontario.MethodsApproximately 100 health professionals were trained as delirium screeners. On ‘Delirium Day’, all patients ≥ 65 years of age in non-critical care areas in all acute care sites in Hamilton were identified. Those willing to take part in the prevalence study were assessed for delirium using the Standardized Mini-Mental State Examination and the Confusion Assessment Method. The Research Ethics Boards at Hamilton Health Sciences and St. Joseph’s Healthcare Hamilton approved this quality assurance project.ResultsOf the 562 patients eligible for screening, eight were excluded and six did not have sufficient data collected to assess for delirium. Of the 548 individuals screened for delirium, 10.6% screened positive. Prevalence estimates ranged by site from 0% to 21% and type of unit from 3.8% to 16%. Recognition of delirium by nursing staff was fair; but, documentation was usually absent.ConclusionWhile the prevalence rates were somewhat lower than in other studies, the results support the need for education among health-care providers in the prevention, identification, and management of delirium.

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Delirium in the Intensive Care Unit: Occurrence and Clinical Course in Older Patients

Cited by 498 publications

References 36 publications

EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit

EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit

Effect of Magnesium Level to the Development of Delirium in Patients Under Sedation in Intensive Care Unit

A Quality Assurance Study to Assess the One-Day Prevalence of Delirium in Elderly Hospitalized Patients

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