Delirium and quality of life in critically ill patients: a prospective cohort
            study

Luz, Lúcia Fabiane da Silva; Santos, Moreno Calcagnotto dos; Ramos, Tiago Almeida; Almeida, Clarissa Balbão de; Rover, Márcia Cristina; Dal’Pizzol, Claudia Pellizzer; Pohren, Cristiane Letícia da Silva; Martins, Aline Vanessa da Silva; Boniatti, Márcio Manozzo

doi:10.5935/0103-507x.20200072

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…The EQ VAS evidenced that they had a better perception of their health status than expected, which could be related to the feeling of being a survivor of the pandemic. Additionally, there is controversy about the impact of ICU‐delirium on QoL after hospital discharge (Abelha et al, 2013 ; Luz et al, 2020 ). In this study, ICU‐delirium was included as inclusion criteria, although not a mandatory one and it might have led to the underestimation of HRQoL scores.…”

Section: Discussionmentioning

confidence: 99%

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Characteristics and influence on quality of life of new‐onset pain in critical COVID‐19 survivors

Ojeda

Calvo

Cuñat

et al. 2021

European Journal of Pain

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Background: Pain is a clinical feature of COVID-19, however, data about persistent pain after hospital discharge, especially among ICU survivors is scarce. The aim of this study was to explore the incidence and characteristics of new-onset pain and its impact on Health-Related Quality of Life (HRQoL), and to quantify the presence of mood disorders in critically ill COVID-19 survivors.Methods: This is a preliminary report of PAIN-COVID trial (NCT04394169) presenting a descriptive analysis in critically ill COVID-19 survivors, following in person interview 1 month after hospital discharge. Pain was assessed using the Brief Pain Inventory, the Douleur Neuropathique 4 questionnaire and the Pain Catastrophizing Scale. HRQoL was evaluated with the EQ 5D/5L, and mood disorders with the Hospital Anxiety and Depression Scale (HADS).Results: From 27 May to 19 July 2020, 203 patients were consecutively screened for eligibility, and 65 were included in this analysis. Of these, 50.8% patients reported new-onset pain; 38.5% clinically significant pain (numerical rating score ≥3 for average pain intensity); 16.9% neuropathic pain; 4.6% pain catastrophizing thoughts, 44.6% pain in ≥2 body sites and 7.7% widespread pain. Patients with new-onset pain had a worse EQ-VAS and EQ index value (p < 0.001). Pain intensity was negatively correlated to both the former (Spearman ρ: −0.546, p < 0.001) and the latter (Spearman ρ: −0.387, p = 0.001). HADS anxiety and depression values equal or above eight were obtained in 10.8% and 7.7% of patients, respectively. Conclusion: New-onset pain in critically ill COVID-19 survivors is frequent, and it is associated with a lower HRQoL. Trial registration No.: NCT04394169. Registered 19 May 2020. https://clini caltr ials.gov/ct2/show/NCT04 394169. Significance: A substantial proportion of severe COVID-19 survivors may develop clinically significant persistent pain, post-intensive care syndrome and chronic ICU-related pain. Given the number of infections worldwide and the unprecedented size of the population of critical illness survivors, providing

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Section: Discussionmentioning

confidence: 99%

“…Additionally, there is controversy about the impact of ICU-delirium on QoL after hospital discharge (Abelha et al, 2013;Luz et al, 2020). In this study, ICU-delirium was included as inclusion criteria, although not a mandatory one and it might have led to the underestimation of HRQoL scores.…”

Section: Hrqolmentioning

confidence: 99%

Characteristics and influence on quality of life of new‐onset pain in critical COVID‐19 survivors

Ojeda

Calvo

Cuñat

et al. 2021

European Journal of Pain

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Prophylactic Minocycline for Delirium in Critically Ill Patients

Dal-Pizzol,

Coelho,

Simon

et al. 2024

CHEST

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Investigating the effect of implementing a sensory stimulation program by family members on delirium status of brain injury patients hospitalized in the intensive care unit: A randomized clinical trial

Molavynejad

Adineh

Elahi

et al. 2023

Journal of Education and Health Promotion

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BACKGROUND: Delirium is the most common psychological disorder in brain injury patients hospitalized in the intensive care unit (ICU), one of the leading causes of which can be sensory deprivation or sensory overload. This study aimed to determine the effect of implementing a sensory stimulation program by family members on the delirium status of ICU-hospitalized brain injury patients. MATERIALS AND METHODS: In this randomized controlled clinical trial, 66 brain injury patients hospitalized in the ICUs were assigned to intervention and control groups using stratified random sampling. For the intervention group, a sensory stimulation program was implemented by family members for 1 h a day during the ICU stay. The control group received routine care. Patients' delirium status was assessed daily using the confusion assessment method for the intensive care unit (CAM-ICU). Data were analyzed by the SPSS software version 22, using Chi-square, independent t-test, and Binary logistic regression model tests, at a significance level of 0.05. RESULTS: Odds of delirium Incidence in the intervention group was 94% lower than in the control group (OR = 0.057, 95% CI 0.017, 0.19, P = 0.001). There is a significant difference between the two groups in terms of length of delirium (P = 0.001), stay in ICU (P = 0.001) and mechanical ventilation (P = 0.001). The mean of all three variables in the intervention group was lower than the control group. CONCLUSIONS: Implementing of sensory stimulation program by the family members, as a non-pharmacological method, can reduce the incidence of delirium in brain injury patients admitted to ICU.

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Delirium and quality of life in critically ill patients: a prospective cohort study

Cited by 3 publications

References 28 publications

Characteristics and influence on quality of life of new‐onset pain in critical COVID‐19 survivors

Characteristics and influence on quality of life of new‐onset pain in critical COVID‐19 survivors

Prophylactic Minocycline for Delirium in Critically Ill Patients

Investigating the effect of implementing a sensory stimulation program by family members on delirium status of brain injury patients hospitalized in the intensive care unit: A randomized clinical trial

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