Delineation of signaling routes that underlie differences in macrophage phenotypic states
Tiberiu Totu,
Jonas Bossart,
Katharina Hast
et al.
Abstract:Macrophages represent a major immune cell type in tumor microenvironments, they exist in multiple functional states and are of a strong interest for therapeutic reprogramming. While signaling cascades defining pro-inflammatory macrophages are better characterized, pathways that drive polarization in immunosuppressive macrophages are incompletely mapped. Here, we performed an in-depth characterization of signaling events in primary human macrophages in different functional states using mass spectrometry-based p… Show more
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