Delineation of cryptogenic Lennox–Gastaut syndrome and myoclonic astatic epilepsy using multiple correspondence analysis

Kamińska, Anna; Ickowicz, Abel; Plouin, Perrine; Bru, M.; Dellatolas, Georges; Dulac, Olivier

doi:10.1016/s0920-1211(99)00021-2

Cited by 127 publications

(113 citation statements)

References 10 publications

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“…Myoclonic-astatic epilepsy with favourable outcome was considered as being generalised idiopathic and myoclonic-astatic epilepsy with unfavourable outcome as being part of the cryptogenic or symptomatic group (Kaminska et al 1999); (2) aetiology; (3) age at onset of epilepsy; (4) duration of epilepsy, i.e. time interval between age at onset and age at examination; (5) seizure frequency at the time of neuropsychological evaluation (coded in five categories: 0, no seizures in the last year; 1, <1 seizure per trimester; 2, seizures occurring >1 per week to 1 per trimester to; 3, seizures occurring 1 per day to 1 per week; 4, >1 seizure per day); (6) topography of EEG and brain imaging abnormalities, especially in localisation-related epilepsies; (7) AEDs at the time of neuropsychological evaluation.…”

Section: Epilepsy Variablesmentioning

confidence: 99%

Epileptic syndromes, cognitive assessment and school placement: a study of 251 children

Bulteau¹,

Jambaqué²,

Viguier³

et al. 2000

Develop Med Child Neuro

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Two-hundred and fifty-one children (98 girls and 153 boys, aged from 3 to 17 years) with documented diagnosis of epileptic syndrome, IQ measurement, and information on school placement were included in this retrospective study. The relations between these three parameters as well as effects of age at onset and duration of epilepsy, seizure frequency, and number of antiepileptic drugs (AEDs) were analysed. Both IQ and schooling were univariately related to epileptic syndrome, age at onset and duration of epilepsy, and number of AEDs; seizure frequency was related to IQ but not to school placement. Multiple regression showed that IQ was independently related to epileptic syndrome and AED; multiple logistic regression showed that type of school (mainstream versus adapted or special) was independently related to IQ and AED. Children with idiopathic generalised or with localisation-related epilepsy had higher IQ scores and higher probability of mainstream schooling than those with symptomatic or cryptogenic generalised epilepsies or epileptic syndromes which were undetermined. Subtests profile of intelligence scale in localisation-related epilepsies showed different specific cognitive deficits, according to the location of the epileptic focus.

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Section: Epilepsy Variablesmentioning

confidence: 99%

Epileptic syndromes, cognitive assessment and school placement: a study of 251 children

Bulteau¹,

Jambaqué²,

Viguier³

et al. 2000

Develop Med Child Neuro

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“…Myoclonic-atonic epilepsy is considered a presumably genetic syndrome with variable prognosis, and although most of patients reach seizure remission, the cognitive development remains uncertain [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…Later on, a few studies highlighted familial history for epilepsy in up to 32% of affected children [1][2][3]. During the last years, several mutations in SCN1A, SCN1B, GABRG2, and SLC2A1 genes have been reported in single cases of MAE [4,5].…”

Section: Introductionmentioning

confidence: 99%

CHD2 mutations are a rare cause of generalized epilepsy with myoclonic–atonic seizures

Trivisano

Striano

Sartorelli

et al. 2015

Epilepsy & Behavior

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“…Seizures begin as generalized tonic-clonic, but are eventually followed by myoclonic astatic seizures of increasing frequency. Neuropsychological outcome in children with myoclonic astatic epilepsy is quite variable and depends on the course of the seizure disorder (Kaminska et al 1999;Oguni et al 2002). Patients who present with developmental delay are sometimes misdiagnosed, because they share features of patients with idiopathic LennoxGastaut syndrome.…”

Section: Myoclonic Astatic Epilepsymentioning

confidence: 99%

“…However, several studies have argued that these are indeed two separate entities. Kaminska et al (1999) examined the clinical profiles and outcome of 72 children with idiopathic generalized epilepsy and found that they were able to classify them into three distinct groups:…”

Section: Myoclonic Astatic Epilepsymentioning

confidence: 99%

Neuropsychological Deficits in Childhood Epilepsy Syndromes

MacAllister

Schaffer

2007

Neuropsychol Rev

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Seizure disorders are relatively common in childhood, and the International League Against Epilepsy (ILAE) provides a hierarchical classification system to define seizure types. At the final level of classification, specific epilepsy syndromes are defined that represent a complex of signs and symptoms unique to an epilepsy condition. The present review discusses the issues related to several of these epilepsy syndromes in childhood, including those classified as generalized idiopathic epilepsies (e.g., childhood absence epilepsy, juvenile absence epilepsy, juvenile myoclonic epilepsy), focal epilepsies (benign rolandic epilepsy, occipital epilepsy, temporal lobe epilepsy, frontal lobe epilepsy) and the "epileptic encephalopathies," including Dravet's Syndrome, West Syndrome, Lennox-Gastaut Syndrome, Myoclonic Astatic Epilepsy, and Landau-Kleffner Syndrome. For each syndrome, the epidemiology, clinical manifestations, treatments, and neuropsychological findings are discussed.

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Delineation of cryptogenic Lennox–Gastaut syndrome and myoclonic astatic epilepsy using multiple correspondence analysis

Cited by 127 publications

References 10 publications

Epileptic syndromes, cognitive assessment and school placement: a study of 251 children

Epileptic syndromes, cognitive assessment and school placement: a study of 251 children

CHD2 mutations are a rare cause of generalized epilepsy with myoclonic–atonic seizures

Neuropsychological Deficits in Childhood Epilepsy Syndromes

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