Abstract:Gene therapy using plasmid DNA (pDNA) is well-explored for variety of genetic diseases. However, its susceptibility to enzymatic degradation desires an optimal delivery system for efficient cellular uptake, transfection, and stability in vivo. Non-viral vectors like lipoplexes and LNPs have gained traction but there is no comparative evaluation of these lipid nanocarriers to deliver pDNA. Here, we demonstrated parallel comparison of both formulation components and technology for proficient pDNA delivery. Catio… Show more
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