Déleucocytation des produits sanguins et infections post-transfusionnelles

A multicentre evaluation of a new filtration protocol for leucocyte depletion of high‐haematocrit red blood cells collected by an automated blood collection system

“…It has been established that leucoreduction can reduce the number of non‐haemolytic febrile transfusion reactions [1], as well as the occurrence of alloimmunization [2,3], in patients receiving multiple transfusions. Reduction of transfusion‐transmitted disease [4]– especially cytomegalovirus (CMV) [5,6]– is generally also considered to be an established benefit of leucodepletion. Aside from these proven benefits, some studies have additionally suggested further potential advantages of leucoreduction, for instance, improvement in the functional quality of erythrocytes during storage [7,8] and a slower decline of important parameters of metabolism (such as intraerythrocyte ATP and extracellular potassium levels) in filtered products, which is thought to be linked to the lower levels of contaminating enzymes released from lysed leucocytes or platelets in the filtered product [9–11].…”