Deletions of Chromosomes 9 and 8p in Histologically Normal Urothelium of Patients with Bladder Cancer

Stoehr, Robert; Zietz, Sabrina; Burger, Maximilian; Filbeck, Thomas; Denzinger, Stefan; Obermann, Ellen C.; Hammerschmied, Christine G.; Knuechel, Ruth; Hartmann, Arndt

doi:10.1016/j.eururo.2004.07.012

Cited by 64 publications

(32 citation statements)

References 18 publications

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“…Steidl et al [16] showed by FISH analyzes that tumors and their adjacent normal urothelium were affected by similar chromosomal aberrations. Genomic imbalances in normal urotheliun have also repeatedly been shown by CGH and LOH [17,18,19] e.g., Stoehr et al [20] found LOH of chromosomes 9 and 8 in histologically normal epithelium in five out of fifteen patients. Thirty cases with no history of UC were used as controls and no LOH was found.…”

Section: Premalignant Lesions and Morphologically Normal Urothelium Imentioning

confidence: 94%

On the Origin of Syn- and Metachronous Urothelial Carcinomas

Höglund

2007

European Urology

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Word count: 3 994Take home message: An alternative model for the origin of syn-and metachronous tumors that better explain the existing genetic data is described. 2 AbstractObjective: To evaluate existing models for the origin of meta-and synchronous urothelial carcinomas in light of the accumulated genetic data. Methods Conclusion:The proposed model can better account for the existing genetic and histological data on syn-and metachronous urothelial carcinomas.3

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Section: Premalignant Lesions and Morphologically Normal Urothelium Imentioning

confidence: 94%

On the Origin of Syn- and Metachronous Urothelial Carcinomas

Höglund

2007

European Urology

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“…2,[4][5][6][7] It has therefore been suggested that loss of 9q may be the earliest event in the initiation of bladder cancer. 8,9 Deletions at chromosome arm 8p are also frequent but predominantly associated with advanced papillary bladder tumours.…”

mentioning

confidence: 99%

Chromosome 9 deletions are more frequent than FGFR3 mutations in flat urothelial hyperplasias of the bladder

Oers

Adam

Denzinger

et al. 2006

Intl Journal of Cancer

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Flat urothelial hyperplasias (FUHs) in patients with papillary bladder tumours frequently show deletions of chromosome 9, suggesting that FUH could be the first neoplastic step in the development of papillary bladder cancer. FGFR3 mutations are frequent in non-invasive papillary tumours with low risk of progression. Our aim was to investigate the frequency of FGFR3 mutations and deletions of chromosomes 9p/q and 8p/q in FUH. Thirty FUH and 9 simultaneous or consecutive tumours were detected by 5-ALA-based photodynamic cystoscopy. DNA was isolated from frozen sections and whole genome amplification was done by I-PEP-PCR, followed by LOH analysis on chromosomes 8p/q and 9p/q. FGFR3 mutations were detected by SNaPshot analysis. LOH analysis on FUH revealed deletions at 9p/q (11/30, 37%) and 8p/q (3/30, 10%). FGFR3 mutations were found in 7/30 FUH (23%). Only 2 FUH showed an FGFR3 mutation without deletions of chromosome 9. In contrast, 6 FUH revealed chromosome 9 deletions but wild type FGFR3 (p 5 0.03). These results suggest that chromosome 9 deletions are the earliest genetic alterations in bladder cancer. The detection of FGFR3 mutations in FUH further supports the role of this lesion as precursor of papillary bladder cancer. ' 2006 Wiley-Liss, Inc.

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“…[6][7][8] Assessing the differential gene expression profiles between aggressive BTCC and adjacent microscopically normal mucosa is of interest in understanding bladder carcinogenesis and/or progression, identifying specific diagnostic markers, and searching for potential targets for drug therapy. Construction and expressed sequence tag (EST) sequencing of a subtractive cDNA library by suppression subtractive hybridization (SSH) can develop such a gene expression profile of a given biologic source.…”

Section: Introductionmentioning

confidence: 99%