Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma

Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring

“… 51 RHOH encodes a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes and has been implicated in non-Hodgkin’s lymphoma. 52 PHOX2B is a transcription factor involved in neuroblastoma. 53 In contrast to PHOX2B , which is recessive, the tumor-suppressive effects of SLC34A2 and RHOH are dominant, 25 indicating that the perturbation of one copy of these genes is sufficient to contribute to carcinogenesis, and their combined effect due to chr4p loss may be providing a selective advantage in TNBC.…”

Evolution of chromosome arm aberrations in breast cancer through genetic network rewiring

“…These include SLC34A2, which encodes a pH-sensitive sodium-dependent phosphate transporter 47 and N4BP2 , which encodes 5’-polynucleotide kinase, playing a role in DNA repair, which have been implicated in lung cancer 48 . RHOH encodes a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes and has been implicated in non-Hodgkin’s lymphoma 49 . PHOX2B is a transcription factor involved in neuroblastoma 50 .…”

“…N4BP2 encodes 5'-polynucleotide kinase, which may play a role in DNA repair and is involved in lung carcinogenesis 28 . RHOH encodes a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes that is a negative regulator of hematopoietic progenitor cell proliferation, survival and migration contributing to non-Hodgkin's lymphoma 29 . PHOX2B is a transcription factor involved in neuroblastoma 30 .…”