Deletion of GSTM1 and GSTT1 Genes and Lung Cancer Survival: a Systematic Review

Ramos-Hernández, Cristina; Mouronte-Roibás, Cecilia; Dios, Juan Miguel Barros; Fernández-Villar, Alberto; Ruano-Raviña, Alberto

doi:10.5301/tj.5000621

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…According to reports in the literature, the American GSTM1 gene deletion rate is 23-62%, Europeans 39-62%, Africans 23-48%, and Asians 33-63%. 39 The GSTT1 gene deletion rate is roughly 22-31% for Americans, 10-21% for Europeans, 15-26% for Africans, and 16-64% for Asians. 39 The GSTM1 and GSTT1 gene deletion rates are extensively regional and racially diverse, which may be due to differences in exposure to geographic differences, environment, and diet.…”

Section: Discussionmentioning

confidence: 99%

“…39 The GSTT1 gene deletion rate is roughly 22-31% for Americans, 10-21% for Europeans, 15-26% for Africans, and 16-64% for Asians. 39 The GSTM1 and GSTT1 gene deletion rates are extensively regional and racially diverse, which may be due to differences in exposure to geographic differences, environment, and diet. Our results show that the gene deletion rate of GSTM1 is 36.4%, consistent with the above results.…”

Section: Discussionmentioning

confidence: 99%

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Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population

Yan¹,

Duan²,

Fu³

et al. 2020

NDT

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Background: Glutathione S-transferase (GST) is an important antioxidant enzyme in the body. The weakening of the antioxidant system causes damage to the cells and tissues that make up the organism, adversely affects the function of the nervous system, and ultimately leads to schizophrenia (SCZ). Previous studies have yielded inconsistent results across different ethnic populations. Purpose: This case-control study was carried out to investigate whether genetic polymorphisms in GST could be associated with SCZ in the Chinese Han population. Patients and Methods: A total of 794 participants, including 379 SCZ patients (case group) and 415 healthy individuals (control group), were genotyped by polymerase chain reaction-restriction fragment length for polymorphisms in GST genes. Results: The study found that the frequency of the GSTM1 null genotype was higher in case group than control group (p=0.003). The frequency of the GSTM1 and GSTT1 double null genotype was also higher in case group than control group (p=0.008). Conclusion: We conclude that the GSTM1 null genotype and the GSTM1 and GSTT1 double null genotype may be related to the onset of SCZ in Chinese Han population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population

Yan¹,

Duan²,

Fu³

et al. 2020

NDT

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“…In line with our findings, Ren et al observed that the presence of ERCC1 rs11615 polymorphism (C/T or T/T) was associated with longer survival (p = 0.014) 30 . Furthermore, Ramos et al in a recent systematic review, analyzed the association between GSTM1 and GSTT1 deletion and survival, concluding that most studies showed no effect or a slight trend towards a worse survival 13 . As can be seen, the results reported by these papers cited are heterogeneous.…”

Section: Discussionmentioning

confidence: 99%

“…This could be one reason why no association with survival is observed in never-smokers. GSTM1 and/or GSTT1 deletion produces an absence of enzymatic activity with an enhanced effect of chemotherapy treatment, greater oxidative damage in tumor cells and ensuingly higher toxicity, causing an expected probable increase in survival 13 .…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in the BER and NER pathways and their influence on survival and toxicity in never-smokers with lung cancer

Casal-Mouriño

Ruano-Raviña

Torres-Durán

et al. 2020

Sci Rep

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Polymorphisms in DNA repair pathways may play a relevant role in lung cancer survival in never-smokers. Furthermore, they could be implicated in the response to chemotherapy and toxicity of platinum agents. The aim of this study was to evaluate the influence of various genetic polymorphisms in the BER and NER DNA repair pathways on survival and toxicity in never-smoker LC patients. The study included never-smokers LC cases diagnosed from 2011 through 2019, belonging to the Lung Cancer Research In Never Smokers study. A total of 356 never-smokers cases participated (79% women; 83% adenocarcinoma and 65% stage IV). Survival at 3 and 5 years from diagnosis was not associated with genetic polymorphisms, except in the subgroup of patients who received radiotherapy or chemo-radiotherapy, and presented with ERCC1 rs3212986 polymorphism. There was greater toxicity in those presenting OGG1 rs1052133 (CG) and ERCC1 rs11615 polymorphisms among patients treated with radiotherapy or chemo-radiotherapy, respectively. In general, polymorphisms in the BER and NER pathways do not seem to play a relevant role in survival and response to treatment among never-smoker LC patients.

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“…Consequently, individuals homozygous for the GSTM1 or GSTT1-null allele have a complete absence of GSTM1 and GSTT1 activity, whereas individuals with two copies of the GSTM1 or GSTT1 genes have reference protein levels. 12,13 There is some evidence that these deletion genotypes may play a role in toxicity, response to treatment, and survival in some cancers, [14][15][16] including cancer of the ovary. 8 In contrast to the commonly studied GSTM1 and GSTT1 genotypes, the GSTP1 c.313A>G (rs1695) is an exonic single nucleotide polymorphism (SNP) that causes an amino acid substitution and results in an isoleucine to valine (Ile > Val) change at codon 105 of the enzyme.…”

Section: What Does This Study Add To Our Knowledge?mentioning

confidence: 99%

GSTP1andABCB1Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel‐Based Chemotherapy in Ovarian Cancer

Ferracini

Lopes‐Aguiar

Lourenço

et al. 2020

Clinical Translational Sci

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Variation in drug disposition genes might contribute to susceptibility to toxicities and interindividual differences in clinical management on chemotherapy for epithelial ovarian cancer (EOC). This study was designed to explore the association of GST and ABCB1 genetic variation with hematologic and neurologic toxicity, changes in chemotherapy, and disease prognosis in Brazilian women with EOC. A total of 112 women with a confirmed histological diagnosis of EOC treated with carboplatin/paclitaxel were enrolled (2014–2019). The samples were analyzed by multiplex polymerase chain reaction (PCR) for the deletion of GSTM1 and GSTT1 genes. GSTP1 (c.313A>G/rs1695) and ABCB1 (c.1236C>T/rs1128503; c.3435C>T/rs1045642; c.2677G>T>A/rs2032582) single nucleotide polymorphisms (SNPs) were detected by real‐time PCR. Subjects with the GSTP1 c.313A>G had reduced risk of anemia (odds ratio (OR): 0.17, 95% confidence interval (CI): 0.04–0.69, P = 0.01, dominant model) and for thrombocytopenia (OR: 0.27, 95% CI: 0.12–0.64, P < 0.01; OR 0.18, 95% CI 0.03–0.85, P = 0.03, either dominant or recessive model), respectively. The GSTP1 c.313A>G AG genotype was associated with a lower risk of dose delay (OR: 0.35, 95% CI: 0.13–0.90, P = 0.03). The ABCB1 c.1236C>T was associated with increased risk of thrombocytopenia (OR: 0.15, 95% CI: 0.03–0.82, P = 0.03), whereas ABCB1 c.3435C>T had increased risk of grade 2 and 3 neurotoxicity (OR: 3.61, 95% CI: 1.08–121.01, P = 0.03) in recessive model (CC + CT vs. TT). This study suggests that GSTP1 c.313A>G, ABCB1 c.1236C>T, and c.3435C>T SNP detection is a potential predictor of hematological toxicity and neurotoxicity and could help predict the clinical management of women with EOC.

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Deletion of GSTM1 and GSTT1 Genes and Lung Cancer Survival: a Systematic Review

Cited by 7 publications

References 22 publications

<p>Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population</p>

<p>Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population</p>

Polymorphisms in the BER and NER pathways and their influence on survival and toxicity in never-smokers with lung cancer

GSTP1andABCB1Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel‐Based Chemotherapy in Ovarian Cancer

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