Deletion of Epstein-Barr virus latent membrane protein 1 gene in united states and Brazilian Hodgkin's disease and reactive lymphoid tissue: High frequency of a 30-bp deletion

Hayashi, Kazuhiko; Chen, Wen-Gang; Chen, Yuanyuan; Bacchi, Mírian Rumenos Piedade; Bacchi, Carlos E.; Alvarenga, Marcelo; Abreu, Eliane S.; Chang, Karen L.; Weiss, Lawrence M.

doi:10.1016/s0046-8177(97)90231-8

Cited by 32 publications

(26 citation statements)

References 24 publications

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“…Particularly in Argentina, the deleted LMP1 variant was previously preferentially detected in tumor samples rather than in samples from healthy individuals, either adults (8,9) or children (5). The predominance of the del30 variant within tumors also was described in the rest of South America and Mexico, and it is in this geographic region that this distinct distribution scheme is more clearly observed (6,7,11,14,18). In the present series, del30 variants were detected in tumor samples and in IM with a similar high incidence.…”

Section: Discussionmentioning

confidence: 92%

Distinctive Epstein-Barr Virus Variants Associated with Benign and Malignant Pediatric Pathologies: LMP1 Sequence Characterization and Linkage with Other Viral Gene Polymorphisms

et al. 2012

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The ubiquitous Epstein-Barr virus (EBV) is related to the development of lymphoma and is also the etiological agent for infectious mononucleosis (IM). Sequence variations in the gene encoding LMP1 have been deeply studied in different pathologies and geographic regions. Controversial results propose the existence of tumor-related variants, while others argued in favor of a geographical distribution of these variants. Reports assessing EBV variants in IM were performed in adult patients who displayed multiple variant infections. In the present study, LMP1 variants in 15 pediatric patients with IM and 20 pediatric patients with EBV-associated lymphomas from Argentina were analyzed as representatives of benign and malignant infections in children, respectively. A 3-month follow-up study of LMP1 variants in peripheral blood cells and in oral secretions of patients with IM was performed. Moreover, an integrated linkage analysis was performed with variants of EBNA1 and the promoter region of BZLF1. Similar sequence polymorphisms were detected in both pathological conditions, IM and lymphoma, but these differ from those previously described in healthy donors from Argentina and Brazil. The results suggest that certain LMP1 polymorphisms, namely, the 30-bp deletion and high copy number of the 33-bp repeats, are associated with EBV-related pathologies, either benign or malignant, instead of just being tumor related. Additionally, this is the first study to describe the Alaskan variant in EBV-related lymphomas that previously was restricted to nasopharyngeal carcinomas from North America.

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Section: Discussionmentioning

confidence: 92%

Distinctive Epstein-Barr Virus Variants Associated with Benign and Malignant Pediatric Pathologies: LMP1 Sequence Characterization and Linkage with Other Viral Gene Polymorphisms

et al. 2012

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“…9 Studies of Hodgkin's disease and nasal lymphoma showed lower prevalence of del-LMP-1 for the lymphoma group than for the reactive lymphoid tissue group. 28,29 On the other hand, investigations found a high prevalence of del-LMP-1 in Hodgkin's disease patients with HIV infection, in contrast to ordinary Hodgkin's disease cases. 1 -3 In south China and Taiwan, the endemic regions of NPC, a predominance of the 30-bp deleted variant was found.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of LMP‐1 gene in tonsils and non‐neoplastic nasopharynxes by nest‐polymerase chain reaction in Taiwan

et al. 2004

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“…Primary EBV + lymphomas were obtained from an area where an extremely high (f90%) association between EBV and pediatric Burkitt's type histology has been reported (15,16). Pediatric BLs (BL-1, BL-2, BL-3, BL-4, and BL-6) and EBV + DLBCLs from AIDS patients (DLBCL-1, DLBCL-2, and DLBCL-3) were obtained from the residual tumor of patient biopsies.…”

Section: Methodsmentioning

confidence: 99%

EBV MicroRNAs in Primary Lymphomas and Targeting of CXCL-11 by ebv-mir-BHRF1-3

et al. 2008

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EBV-encoded microRNAs (miRNAs) have been identified and their functions are being studied. The expression pattern of these miRNAs in clinical samples of EBV-associated nonHodgkin's lymphomas is unknown. We analyzed five primary ''endemic'' pediatric Burkitt's lymphomas (BL), two acquired immunodeficiency syndrome (AIDS)-related type I latency BL lines, a type III latency line, three EBV + primary effusion lymphomas (PEL), and three AIDS-related diffuse large B-cell lymphomas (DLBCL) for expression of EBV-encoded miRNAs.

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Deletion of Epstein-Barr virus latent membrane protein 1 gene in united states and Brazilian Hodgkin's disease and reactive lymphoid tissue: High frequency of a 30-bp deletion

Cited by 32 publications

References 24 publications

Distinctive Epstein-Barr Virus Variants Associated with Benign and Malignant Pediatric Pathologies: LMP1 Sequence Characterization and Linkage with Other Viral Gene Polymorphisms

Distinctive Epstein-Barr Virus Variants Associated with Benign and Malignant Pediatric Pathologies: LMP1 Sequence Characterization and Linkage with Other Viral Gene Polymorphisms

Prevalence of LMP‐1 gene in tonsils and non‐neoplastic nasopharynxes by nest‐polymerase chain reaction in Taiwan

EBV MicroRNAs in Primary Lymphomas and Targeting of CXCL-11 by ebv-mir-BHRF1-3

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