Deletion allele of the angiotensin-converting enzyme gene as a risk factor for pneumonia in elderly patients

Morimoto, Shigeto; Okaishi, Kohya; Onishi, Masanori; Katsuya, Tomohiro; Yang, Jin; Okuro, Masashi; Sakurai, Shoroku; Onishi, Toshio; Ogihara, Toshio

doi:10.1016/s0002-9343(01)01071-3

Cited by 45 publications

(49 citation statements)

References 29 publications

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“…The role of the ACE polymorphism has received extensive study in several disease states but relatively little is known of its role in determining the outcome of infections. 17,18,22 The frequency of the D allele (0.60) in our study population of mechanically ventilated VLBW infants is not different than previously reported in our local population or for other groups. 16,21,23 This finding suggests that the D allele is not a risk or protective factor for either premature birth or the need for mechanical ventilation.…”

Section: Discussioncontrasting

confidence: 54%

“…The majority of late BSI infections were CONS which is not associated with high mortality rates. 4 Morimoto et al 17 found that the D allele is a risk factor for pneumonia in the elderly. We found a nonsignificant trend for increased nosocomial pneumonia in patients with the D allele in our study group.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 The ACE I/D polymorphism may alter risk for and outcome from sepsis. 17,18 Since tissue ACE regulates inflammatory responses, the DD genotype or D allele (associated with higher tissue ACE levels) might be associated with adverse outcome from sepsis in VLBW infants.…”

Section: Introductionmentioning

confidence: 99%

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Angiotensin Converting Enzyme Insertion/Deletion Polymorphism Does Not Alter Sepsis Outcome in Ventilated Very Low Birth Weight infants

2004

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OBJECTIVE:This study compared the effect of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphisms on the incidence and outcome of sepsis in ventilated very low birth weight infants. STUDY DESIGN:Infectious complications were retrospectively determined in 295 (234 African-American, 58 Caucasian and three Hispanic) mechanically ventilated very low birth weight (VLBW) infants (<1500 g at birth) and compared ACE I/D genotype. RESULTS:The incidence of the D allele in the study population was 0.60. A total of 113 (38.3%) infants were homozygous DD, 128 (43.4%) were heterozygous ID and 54 (18.3%) were homozygous II. One or more episodes of late BSI developed in 28 (52%) of 54 infants with the II genotype, 66 (52%) of 128 infants with the ID genotype and 52 (46%) of 113 infants with the DD genotype (p ¼ 0.618). Neither the rates of non-CONS BSI (II: 24%, ID: 23%, DD: 22%; p ¼ 0.937) nor multiple bacteremic/fungemic episodes (II: 13%, ID: 16%, DD: 12%; p ¼ 0.641) were different between genotype groups. The ACE I/D polymorphism had no effect on sepsis-related mortality (II: 7%, ID: 5%, DD: 4%; p ¼ 0.692). Sepsis mortality for infants with late BSI was 14% in infants with the II genotype, 9% with the ID genotype and 10% with the DD genotype (p ¼ 0.764). CONCLUSIONS:The ACE I/D polymorphism does not have a significant effect on the incidence or outcome of sepsis in ventilated VLBW infants.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

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Angiotensin Converting Enzyme Insertion/Deletion Polymorphism Does Not Alter Sepsis Outcome in Ventilated Very Low Birth Weight infants

2004

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“…In the recent study of Morimoto et al, 21 the relative risks (DD vs IIϩID) were 2.9 for pneumonia and 4.4 for fatal pneumonia. To detect a clinical significant effect of ACE I/D polymorphism on pneumonia outcome, we hypothesized that carriers with the DD genotype of the ACE gene would have a threefold-increased mortality risk compared with carriers of the II and ID genotypes.…”

Section: Sample-size Calculationmentioning

confidence: 89%

“…17 The ACE I/D polymorphism can also been linked to pneumonia because persons with the DD genotype have a lower cough reflex compared with II and ID, 18,19 and the DD genotype carriers have higher serum levels of the proinflammatory angiotensin-II. 20 Morimoto et al 21 already showed that the ACE D allele is an independent risk factor for (fatal) pneumonia in an Asian population. We have explored the hypothesis that the ACE I/D polymorphism affects the risk and clinical outcome of CAP in a Dutch white population.…”

mentioning

confidence: 99%

Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Risk and Outcome of Pneumonia

Garde

Endeman

Deneer

et al. 2008

Chest

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Angiotensin‐converting enzyme insertion/deletion gene polymorphism in Egyptian children with CAP: A case‐control study

Abouzeid

Alkholy

Abdou

et al. 2017

Pediatric Pulmonology

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Deletion allele of the angiotensin-converting enzyme gene as a risk factor for pneumonia in elderly patients

Cited by 45 publications

References 29 publications

Angiotensin Converting Enzyme Insertion/Deletion Polymorphism Does Not Alter Sepsis Outcome in Ventilated Very Low Birth Weight infants

Angiotensin Converting Enzyme Insertion/Deletion Polymorphism Does Not Alter Sepsis Outcome in Ventilated Very Low Birth Weight infants

Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Risk and Outcome of Pneumonia

Angiotensin‐converting enzyme insertion/deletion gene polymorphism in Egyptian children with CAP: A case‐control study

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