Deleterious effects of whole‐body vibration on the spine: A review of in vivo, ex vivo, and in vitro models

Patterson, Folly; Miralami, Raheleh; Tansey, Keith E.; Prabhu, Raj; Priddy, Lauren B.

doi:10.1002/ame2.12163

Cited by 16 publications

(10 citation statements)

References 65 publications

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“…In this context, prolonged exposure to vibration in the construction work environment has been reported to be significantly associated with musculoskeletal disorders, predominantly in the neck, shoulder, and arm [ 7 , 8 ]. Notably, such disorders induced by WBV exposure are manifested by musculoskeletal pain, the chronicity of which, due to the persistence of the stimulus, leads to reduced hours of work activity, impaired emotional well-being and, in general, a worsening of the individual’s quality of life [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Whole Body Vibration: A Valid Alternative Strategy to Exercise?

Bonanni

Cariati

Romagnoli

et al. 2022

JFMK

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Several studies agree that mechanical vibration can induce physiological changes at different levels, improving neuromuscular function through postural control strategies, muscle tuning mechanisms and tonic vibration reflexes. Whole-body vibration has also been reported to increase bone mineral density and muscle mass and strength, as well as to relieve pain and modulate proprioceptive function in patients with osteoarthritis or lower back pain. Furthermore, vibratory training was found to be an effective strategy for improving the physical performance of healthy athletes in terms of muscle strength, agility, flexibility, and vertical jump height. Notably, several benefits have also been observed at the brain level, proving to be an important factor in protecting and/or preventing the development of age-related cognitive disorders. Although research in this field is still debated, certain molecular mechanisms responsible for the response to whole-body vibration also appear to be involved in physiological adaptations to exercise, suggesting the possibility of using it as an alternative or reinforcing strategy to canonical training. Understanding these mechanisms is crucial for the development of whole body vibration protocols appropriately designed based on individual needs to optimize these effects. Therefore, we performed a narrative review of the literature, consulting the bibliographic databases MEDLINE and Google Scholar, to i) summarize the most recent scientific evidence on the effects of whole-body vibration and the molecular mechanisms proposed so far to provide a useful state of the art and ii) assess the potential of whole-body vibration as a form of passive training in place of or in association with exercise.

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Section: Introductionmentioning

confidence: 99%

Whole Body Vibration: A Valid Alternative Strategy to Exercise?

Bonanni

Cariati

Romagnoli

et al. 2022

JFMK

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“…The human lumbar spine has low-frequency vibrations normally within a range of 1-8 Hz. [28,29] We chose a relatively low frequency (0.25 and 0.5 Hz) to ensure the sensing capability even under quasi-static or very low-frequency condition, as well as persevering the spine models under the loading cycles. Also, the axial force on spine usually ranges from 200 N (in relaxed sitting or lying position) to 1000 N (during upright standing or sitting).…”

Section: Resultsmentioning

confidence: 99%

Patient‐Specific Self‐Powered Metamaterial Implants for Detecting Bone Healing Progress

Barri

Zhang

Swink

et al. 2022

Adv Funct Materials

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There is an unmet need for developing a new class of smart medical implants with novel properties and advanced functionalities. Here, the concept of “self‐aware implants” is proposed to enable the creation of a new generation of multifunctional metamaterial implantable devices capable of responding to their environment, empowering themselves, and self‐monitoring their condition. These functionalities are achieved via integrating nano energy harvesting and mechanical metamaterial design paradigms. Various aspects of the proposed concept are highlighted by developing proof‐of‐concept interbody spinal fusion cage implants with self‐sensing, self‐powering, and mechanical tunability features. Bench‐top testing is performed using synthetic biomimetic and human cadaver spine models to evaluate the electrical and mechanical performance of the developed patient‐specific metamaterial implants. The results show that the self‐aware cage implants can diagnose bone healing process using the voltage signals generated internally through their built‐in contact‐electrification mechanisms. The voltage and current generated by the implants under the axial compression forces of the spine models reach 9.2 V and 4.9 nA, respectively. The metamaterial implants can serve as triboelectric nanogenerators to empower low‐power electronics. The capacity of the proposed technology to revolutionize the landscape of implantable devices and to achieve better surgical outcomes is further discussed.

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“…Few studies have addressed the effects of vibration, particularly LMHFV, on the IVD [ 48 ]. Interestingly, acute vibration at 15 Hz (0.3 g peak-to-peak acceleration, 30 min) was shown to induce transient expression of anabolic genes including Acan , Col2a1 , biglycan, decorin, and Sox9 , and suppress expression of Mmp13 by murine IVDs cultured ex vivo, with the most pronounced changes detected 6 h following vibration [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Oestrogen and Vibration Improve Intervertebral Disc Cell Viability and Decrease Catabolism in Bovine Organ Cultures

Widmayer

Neidlinger‐Wilke

Witz

et al. 2023

IJMS

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Postmenopausal women are at an increased risk for intervertebral disc degeneration, possibly due to the decrease in oestrogen levels. Low-magnitude, high-frequency vibration (LMHFV) is applied as a therapeutic approach for postmenopausal osteoporosis; however, less is known regarding possible effects on the intervertebral disc (IVD) and whether these may be oestrogen-dependent. The present study investigated the effect of 17β-oestradiol (E2) and LMHFV in an IVD organ culture model. Bovine IVDs (n = 6 IVDs/group) were treated with either (i) E2, (ii) LMHFV or (iii) the combination of E2 + LMHFV for 2 or 14 days. Minor changes in gene expression, cellularity and matrix metabolism were observed after E2 treatment, except for a significant increase in matrix metalloproteinase (MMP)-3 and interleukin (IL)-6 production. Interestingly, LMHFV alone induced cell loss and increased IL-6 production compared to the control. The combination of E2 + LMHFV induced a protective effect against cell loss and decreased IL-6 production compared to the LMHFV group. This indicates possible benefits of oestrogen therapy for the IVDs of postmenopausal women undergoing LMHFV exercises.

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Deleterious effects of whole‐body vibration on the spine: A review of in vivo, ex vivo, and in vitro models

Cited by 16 publications

References 65 publications

Whole Body Vibration: A Valid Alternative Strategy to Exercise?

Whole Body Vibration: A Valid Alternative Strategy to Exercise?

Patient‐Specific Self‐Powered Metamaterial Implants for Detecting Bone Healing Progress

Oestrogen and Vibration Improve Intervertebral Disc Cell Viability and Decrease Catabolism in Bovine Organ Cultures

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