Delayed Visual Evoked Response in Optic Neuritis

Halliday, A. M.; McDonald, W. I.; Mushin, Joan

doi:10.1016/s0140-6736(72)91155-5

Cited by 626 publications

(291 citation statements)

References 8 publications

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“…In clinical applications, in cases of optic neuritis transient stimulation demonstrates an increased peak latency of the P100 component (Halliday et al 1972). …”

Section: Discussionmentioning

confidence: 99%

“…As they did, we tested only one temporal frequency (12 rev/sec). Therefore, we could only compare the phases in two situations but not compute quantitative delays as in previous work (Halliday et al 1972;Adachi-Usami et al 1979) when the phase plots derived from stimulation with different frequencies were employed. But, as stated previously, for the difference between two eyes in a unilateral case, the phase delay difference is a reliable measure and can be directly transformed in the time domain: 360ae is 83 ms. Tobimatsu et al (1991) applied the same method to 5 patients with optic neuropathy and suggested that changes in phase lag of the steady-state VECP was equivalent to changes in the P100 peak for the transient VECP.…”

Section: Discussionmentioning

confidence: 99%

“…The response shows a dominant scalp positive component(P100), while steady-state VECPs at reversal rates above 5Hz approach the sinusoidal shape. Clinically, the transient VECP has a delayed P100 in several pathological conditions of the optic nerve, especially in multiple sclerosis (Halliday et al 1972;Riemslag et al 1982). On the other hand, the quasi-sinusoidal wave form of the steady-state VECPs is very constant, therefore the peak to peak amplitude forms a good criterion for the response.…”

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confidence: 99%

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Steady‐state PVECP is superior to transient PVECP in the diagnosis of optic neuritis

Takasoh

Mizota

1998

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To compare the diagnostic value for optic neuritis between transient pattern visual evoked potentials (PVECP) and steady-state PVECP. Subjects & Methods: We retrospectively studied 86 eyes of 69 patients with optic neuritis who visited our clinic. PVECPs to 3 rev/sec stimulation (transient) and 12 rev/sec stimulation (steady-state), were recorded in all patients. Results: All of the cases with non-recordable transient PVECP showed non recordable steady-state PVECP. Conversely, the cases with non-recordable steady-state PVECP often showed measurable transient PVECP where the latency of the P100 component was delayed. In 51 cases with unilateral optic neuritis, the amplitude ratio of the P100; affected eye/non-affected eye was significantly smaller in the steady-state PVECP than in the transient PVECP. Conclusion:To detect visual dysfunction in optic neuritis, a steady-state PVECP was more sensitive than a transient PVECP.

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“…In clinical applications, in cases of optic neuritis transient stimulation demonstrates an increased peak latency of the P100 component (Halliday et al 1972). …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Steady‐state PVECP is superior to transient PVECP in the diagnosis of optic neuritis

Takasoh

Mizota

1998

Acta Ophthalmologica Scandinavica

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“…Not only was it demonstrated that the PVEP is delayed in patients with optic neuritis, but also that the PVEP delay persists following clinical recovery. 15 They further demonstrated that the VEP could reveal optic nerve conduction delay in the absence of any signs or symptoms of clinical optic nerve involvement. 16 Usually, VEPs showed conduction delay with less marked amplitude change.…”

Section: Optic Nerve Demyelinationmentioning

confidence: 96%

Electrophysiological assessment of optic nerve disease

Holder

2004

Eye

125

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The electrophysiological findings in optic nerve and primary ganglion cell dysfunction are reviewed. The value of the pattern reversal visual-evoked potential (VEP) in the diagnosis of optic nerve disease, and the pattern appearance VEP in the demonstration of the intracranial misrouting associated with albinism, are discussed. The pattern electroretinogram (PERG) is used in the direct assessment of ganglion cell function. The use of PERG or multifocal electroretinography (mfERG), to enable the distinction between VEP delay due to optic nerve disease and that due to macular dysfunction, is described.

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“…In normal subjects, Tr PVECP revealed a positive component around 100 ms generally named P100. The peak latency of the P100 component was used to detect optic nerve disorders, chiasmal lesions (Asselman et al 1975;Halliday et al 1972), and even macular diseases (Lennerstrand 1982;Bass et al 1985). St PVECP showed a quasi-sinusoidal wave form.…”

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confidence: 99%

An amplitude ratio of pattern visually evoked cortical potentials

Fujimoto

1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: We evaluated the amplitude of steady state pattern visually evoked cortical potentials (St PVECP) by comparing the amplitude ratio to transient PVECP (Tr PVECP) with the latency of Tr PVECP in macular, optic nerve, and chiasmal lesions. Methods: PVECPs were obtained by pattern reversal stimulation of both 3 times and 12 times per second from normal subjects and patients. The peak latency of the P100 component of Tr PVECP and the amplitude ratio (St PVECP/ Tr PVECP) were studied. Results: Ratio abnormalities were specifically found in patients with optic and chiasmal lesions who had normal Tr PVECP latency, but not in those with macular lesions. The ratio increased with visual improvement in optic nerve disease and chiasmal lesions. Conclusion: The amplitude ratio was useful in detecting and monitoring optic nerve and chiasmal lesions, and in differentiating optic nerve and chiasmal lesions from macular lesions.

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Delayed Visual Evoked Response in Optic Neuritis

Cited by 626 publications

References 8 publications

Steady‐state PVECP is superior to transient PVECP in the diagnosis of optic neuritis

Steady‐state PVECP is superior to transient PVECP in the diagnosis of optic neuritis

Electrophysiological assessment of optic nerve disease

An amplitude ratio of pattern visually evoked cortical potentials

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