Delayed-Type Hypersensitivity Reaction to Red Tattoo Ink Triggered by Ledipasvir/Sofosbuvir for Hepatitis C: A Case Report

McPhie, Meghan L.; Ren, Kevin; Hendry, Joy; Molin, Sonja; Herzinger, Thomas

doi:10.1159/000513926

Cited by 4 publications

(2 citation statements)

References 11 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Drug-induced tattoo reactions are not very frequent AEs, although tattoo-associated skin reactions have been reported during immune restoration syndrome with highly active antiretroviral therapy for human immunodeficiency virus [16], therapy for hepatitis C [17,18] and tumor necrosis factor α inhibitors [19]. Immune checkpoint inhibitors are also associated with various dermatologic manifestations, including sarcoidosis and granulomatous reactions to tattoos [8,20].…”

Section: Discussionmentioning

confidence: 99%

Tattoo-Associated Skin Reaction in a Melanoma Patient Receiving B-RAF and MEK Inhibitors: A Case Report with an Emphasis on Etiopathogenic and Histological Features

Baratta,

Cazzato,

Foti

et al. 2024

JCM

View full text Add to dashboard Cite

Tattoo-associated cutaneous reactions have become quite frequent given the increasing percentage of tattooed subjects globally and also in Italy. On the other hand, the increasing use of target therapy is showing the ability of these drugs to affect the immune system and also cause adverse tattoo-related reactions. In this paper, we report a case of a 42-year-old patient with stage-IIID melanoma undergoing treatment with Dabrafenib and Trametinib. The patient reported erythema, oedema and scaling in areas of the body containing a black tattoo, and, conversely, no signs and/or symptoms in areas with tattoos of a different color. Histopathological and immunohistochemical features indicated a lympho-histiocytic reaction with a granulomatous morphology, mainly distributed around the vessels and hair adnexa. By discussing the cases reported in the literature prior to ours, we concluded and provided the possible indications of the pathogenesis.

show abstract

Section: Discussionmentioning

confidence: 99%

Tattoo-Associated Skin Reaction in a Melanoma Patient Receiving B-RAF and MEK Inhibitors: A Case Report with an Emphasis on Etiopathogenic and Histological Features

Baratta,

Cazzato,

Foti

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…As the allergen is usually unidentified, the exact pathomechanism of chronic allergic reaction to red ink tattoo is also not fully explained. Presumably, the mechanism is that metabolism of the ink or reaction of an ink antigen with a carrier protein in the dermis over a long time triggers a delayed hypersensitivity reaction [ 17 , 18 ]. In line with the presumed pathophysiology, chronic allergic tattoo reactions occur months or years following body art completion.…”

Section: Discussionmentioning

confidence: 99%

When Body Art Goes Awry—Severe Systemic Allergic Reaction to Red Ink Tattoo Requiring Surgical Treatment

Szulia

Antoszewski

Zawadzki

et al. 2022

IJERPH

View full text Add to dashboard Cite

The aim of this report is to present a case of a patient who developed unusual systemic hypersensitivity reaction to a red-pigmented tattoo and to discuss diagnostic difficulties in case of systemic reactions to tattoo ink. The patient reported erythroderma on his arms and chest accompanied by plaque elevation of red parts of his most recently performed forearm tattoo as his primary symptoms. His health condition entailed a prolonged topical and intravenous immunosuppressive therapy, which proved ineffective. Over a year after emergence of initial symptoms, he presented to the Plastic Surgery Clinic with generalized erythroderma, systemic lymphadenopathy, elevation and granuloma formation in red tattoos on his forearm and complaints of fatigue and inability to participate fully in work-related and social activities. The patient underwent six staged excisions with direct closures, flap plasties and full-thickness skin grafts. Following completion of each surgical resection, the patient’s symptoms gradually subsided. We find this case illustrative of a clinical challenge that delayed hypersensitivity reactions to red tattoos may pose. Furthermore, we provide insights on management of hypersensitivity reactions. This report underlines the importance of social awareness of and public health approach to tattoo complications as key to successful prevention, identification and treatment of adverse reactions to tattoos.

show abstract

Ledipasvir/sofosbuvir

2022

Reactions Weekly

View full text Add to dashboard Cite

Delayed-Type Hypersensitivity Reaction to Red Tattoo Ink Triggered by Ledipasvir/Sofosbuvir for Hepatitis C: A Case Report

Cited by 4 publications

References 11 publications

Tattoo-Associated Skin Reaction in a Melanoma Patient Receiving B-RAF and MEK Inhibitors: A Case Report with an Emphasis on Etiopathogenic and Histological Features

Tattoo-Associated Skin Reaction in a Melanoma Patient Receiving B-RAF and MEK Inhibitors: A Case Report with an Emphasis on Etiopathogenic and Histological Features

When Body Art Goes Awry—Severe Systemic Allergic Reaction to Red Ink Tattoo Requiring Surgical Treatment

Ledipasvir/sofosbuvir

Contact Info

Product

Resources

About