Delayed Topiramate-induced Bilateral Angle-Closure Glaucoma

Czyz, Craig N.; Clark, Cooper M.; Justice, Joshua D.; Pokabla, Michael J.; Weber, Paul A.

doi:10.1097/ijg.0b013e3182948491

Cited by 22 publications

(15 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The findings of our study were in agreement with many previous case reports [18][19][20][21][22][23][24][25] and one of the previous published prospective studies [14]. On the contrary, other studies described changes that were not found in our study [15][16][17].…”

Section: Discussionsupporting

confidence: 93%

Topiramate-induced ocular side effects in Egyptian patients, idiosyncratic versus dose-dependent effect, a prospective study

Thabit

Farouk

2021

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

Background To test the nature of the ocular side effects induced by topiramate (TPM) whether dose dependent or idiosyncratic, and to test various predictors that might influence the occurrence of those side effects. Methods Twenty patients treated with TPM were included in this study. Patients underwent ophthalmic assessment before and after 4 weeks of treatment by stable doses of oral TPM. We examined non-cycloplegic refraction (RF) in diopters, best corrected visual acuity (BCVA), intraocular pressure (IOP) in mmHg, and anterior chamber depth (ACD) in mm. Results There were no statistically significant differences between baseline and follow-up assessments in all tested ophthalmological parameters including errors of RF, ACD, IOP, and the BCVA. One case suffered from painful drop of vision in both eyes with elevated IOP and decreased ACD, and evident myopic shift 1 week after treatment with small dose of TPM. There was no significant effect of age, TPM dose, disease, and gender on all tested variables. Conclusion TPM can induce idiosyncratic, but not dose dependent, ocular side effects, namely myopic shifts and angle closure glaucoma. Those side effects were not disease, age, or gender dependent. However, ethnicity might play a role in induction of those side effects.

show abstract

Section: Discussionsupporting

confidence: 93%

Topiramate-induced ocular side effects in Egyptian patients, idiosyncratic versus dose-dependent effect, a prospective study

Thabit

Farouk

2021

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

show abstract

“…Onset of angle closure secondary to oral administration of topiramate typically occurs within 2 weeks of initiation of therapy, but has been reported to occur as early as 1 to as long as 262 days after starting the medication. 5,6 This form of secondary angle closure is due to the development of a ciliochoroidal effusion that causes angle closure from forward rotation of the lens-iris diaphragm (as opposed to a pupillary block mechanism seen in most patients with primary angle closure). Rhee et al 2 described a 43-year-old patient with topiramate-associated angle closure with high-frequency ultrasound evidence of ciliary process swelling and forward displacement of the lens-iris diaphragm.…”

Section: Discussionmentioning

confidence: 98%

Bilateral Angle Closure Following Use of a Weight Loss Combination Agent Containing Topiramate

Grewal

Goldstein

Khatana

et al. 2015

Journal of Glaucoma

View full text Add to dashboard Cite

show abstract

“…First, young patients diagnosed with AACG might have plateau iris syndrome, which is often treated with argon laser peripheral iridoplasty or pilocarpine. Second, younger AACG patients could be associated with the use of drugs such as topiramate, which is approved as an anti-convulsant for treatment of seizure disorders and for prevention of migraine headaches, and, however, is commonly used in obesity therapeutics 21222324. Those drugs are known to cause secondary angle closure, and treated with medications.…”

Section: Discussionmentioning

confidence: 99%

Nationwide Incidence of Acute Angle Closure Glaucoma in Korea from 2011 to 2015

Park

Kim

et al. 2019

J Korean Med Sci

View full text Add to dashboard Cite

BackgroundDespite the significant disease burden, there is a paucity of data addressing the population-based incidence of acute angle closure glaucoma (AACG). Therefore, we estimated the nationwide, population-based standardized incidence rate of AACG in Korea.MethodsWe conducted a nationwide, population-based, retrospective study using the database of National Health Insurance (NHI) system, which includes the entire Korean population (approximately 50 million people) from 2009 to 2015. We identified patients with incident AACG during the 5-year study period from 2011 to 2015 based on their diagnosis and AACG-related treatments (laser iridotomy and cataract surgery), and estimated age- and gender-standardized incidence rate of AACG during the study period.ResultsWe identified 11,049 patients (8,022 women, 72.6%) with incident AACG during the 5-year study period. Of these, after excluding 6 patients under 20 years old, 11,043 patients (8,020 women, 72.6%) aged ≥ 20 years were included in the analysis. The average standardized incidence rate during the 5-year study period was 59.95 (95% confidence interval [CI], 58.87–61.03) per 1,000,000 person-years. The incidence rates increased sharply with age and peaked at individuals aged 75–79 years; in men, those peaked at the same age group, however, in women, those peaked at individuals aged 70–74 years. Women has a 2.56 folds higher incidence rate (85.84 [95% CI, 84.03–87.66] per 1,000,000 person-years) than men (33.48 [95% CI, 32.33–34.62] per 1,000,000 person-years).ConclusionThe present study provides detailed estimates for AACG incidence according to all age groups and gender through the 5-year study period.

show abstract

Delayed Topiramate-induced Bilateral Angle-Closure Glaucoma

Abstract: This case provides evidence of delayed bilateral angle closure from topiramate and raises questions as to the cellular mechanism of topiramate-induced angle closure, both immediate and delayed.

Cited by 22 publications

References 6 publications

Topiramate-induced ocular side effects in Egyptian patients, idiosyncratic versus dose-dependent effect, a prospective study

Topiramate-induced ocular side effects in Egyptian patients, idiosyncratic versus dose-dependent effect, a prospective study

Bilateral Angle Closure Following Use of a Weight Loss Combination Agent Containing Topiramate

Nationwide Incidence of Acute Angle Closure Glaucoma in Korea from 2011 to 2015

Contact Info

Product

Resources

About