Delayed stress-induced antinociceptive effect of nitric oxide synthase inhibition in the dentate gyrus of rats

Echeverry, Marcela Bermúdez; Guimarães, Francisco Silveira; Oliveira, Marina Amaral de; Prado, Wiliam A.; Bel, Elaine Aparecida Del

doi:10.1016/s0091-3057(02)00964-4

Cited by 13 publications

(11 citation statements)

References 68 publications

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“…The putative involvement of this anomaly is biologically plausible, as CA4 neurons are responsible for visceral sensory and autonomic response [Mollace et al, 2005], via different kinds of neurotransmission. Among these, the 5-HT system is associated with nociception [Echeverry et al, 2002], aggressive behavior [van Goozen and Fairchild, 2006], impulsivity [Cardinal, 2006;Masaki et al, 2006], drug addiction, and threat avoidance [Deakin, 2003] that are all key features in psychopathy [Birbaumer et al, 2005]. As to the lateral expansions in the body and tail of the hippocampus, it is known that the CA3 region is also involved in the processing of emotional and visceral input [Mollace et al, 2005], and in contextual fearconditioning [Daumas et al, 2007].…”

Section: Discussionmentioning

confidence: 99%

Abnormal hippocampal shape in offenders with psychopathy

Boccardi

Ganzola

Rossi

et al. 2009

Human Brain Mapping

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Posterior hippocampal volumes correlate negatively with the severity of psychopathy, but local morphological features are unknown. The aim of this study was to investigate hippocampal morphology in habitually violent offenders having psychopathy. Manual tracings of hippocampi from magnetic resonance images of 26 offenders (age: 32.5 +/- 8.4), with different degrees of psychopathy (12 high, 14 medium psychopathy based on the Psychopathy Checklist Revised), and 25 healthy controls (age: 34.6 +/- 10.8) were used for statistical modelling of local changes with a surface-based radial distance mapping method. Both offenders and controls had similar hippocampal volume and asymmetry ratios. Local analysis showed that the high psychopathy group had a significant depression along the longitudinal hippocampal axis, on both the dorsal and ventral aspects, when compared with the healthy controls and the medium psychopathy group. The opposite comparison revealed abnormal enlargement of the lateral borders in both the right and left hippocampi of both high and medium psychopathy groups versus controls, throughout CA1, CA2-3 and the subicular regions. These enlargement and reduction effects survived statistical correction for multiple comparisons in the main contrast (26 offenders vs. 25 controls) and in most subgroup comparisons. A statistical check excluded a possible confounding effect from amphetamine and polysubstance abuse. These results indicate that habitually violent offenders exhibit a specific abnormal hippocampal morphology, in the absence of total gray matter volume changes, that may relate to different autonomic modulation and abnormal fear-conditioning.

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Section: Discussionmentioning

confidence: 99%

Abnormal hippocampal shape in offenders with psychopathy

Boccardi

Ganzola

Rossi

et al. 2009

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…The putative involvement of this anomaly is biologically plausible, as CA4 neurons are responsible for visceral sensory and autonomic response [Mollace et al,2005], via different kinds of neurotransmission. Among these, the 5‐HT system is associated with nociception [Echeverry et al,2002], aggressive behavior [van Goozen and Fairchild,2006], impulsivity [Cardinal,2006; Masaki et al,2006], drug addiction, and threat avoidance [Deakin,2003] that are all key features in psychopathy [Birbaumer et al,2005]. As to the lateral expansions in the body and tail of the hippocampus, it is known that the CA3 region is also involved in the processing of emotional and visceral input [Mollace et al,2005], and in contextual fear‐conditioning [Daumas et al,2007].…”

Section: Discussionmentioning

confidence: 99%

Biphenyl dioxolanes as circular dichroism probes for the assignment of absolute configuration to aliphatic diols: Extending the scope to anti 1,n‐diols and cyclic syn 1,2‐diols

Scafato

Superchi

2010

Chirality

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We describe herein the use of a flexible biphenyl moiety as efficient chirality probe in the assignment of the absolute configuration (AC) of aliphatic, non-chromophoric diols. The diols are transformed in the corresponding biphenyl dioxolanes in which the biphenyl system has either a P or M torsion depending on the chirality of the diol. As the correlation between biphenyl torsion and diol AC has been established and the sense of torsion is revealed by the sign of the biphenyl A band at 250 nm in the CD spectrum of the dioxolane, then the diols AC can be assigned simply looking at the CD spectra of these derivatives. This approach proved to be general, straightforward, and reliable for anti 1,2- 1,3-, and 1,4-diols bearing both one and two stereogenic centers and for cyclic syn 1,2-diols.

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“…The hippocampus may contributes to the negative affect and avoidance motivation experienced during pain [15] . Stimulation on the hippocampal formation can modulate nociceptive information, and painful stimuli can activate this structure [16,17] . As observed in our research, the discharges of PEN and PIN in the CA1 area were remarkably changed when peripheral traumatic stimulation signal was transferred to the hippocampus.…”

Section: Discussionmentioning

confidence: 99%