Delayed Results of Experimental Afobazole Therapy in Rats after Acute Myocardial Infarction

Крыжановский, С. А.; Цорин, И. Б.; Stolyaruk, V. N.; Ионова, Е. О.; Вититнова, М. Б.

doi:10.1007/s10517-017-3761-7

Cited by 3 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study also showed delayed cardioprotective effects of afobazole, evaluated by using echocardiography in an experim ental myocardial infarction model (rat model of acute myocardial ischemia) (Kryzhanovskii et al, 2017). It has been proposed that the cardiotropic effects of the anxiolytic afobazole were associated with Sigmar1 agonistic effects in cardiomyocytes (Kryzhanovskii et al, 2017(Kryzhanovskii et al, , 2018. However, a recent study showed that chronic Sigmar1 activation ameliorated ventricular remodeling and decreased susceptibility to ventricular arrhythmias after myocardial infarction in rats (Fo et al, 2020).…”

Section: Myocardial Infarctionmentioning

confidence: 99%

“…Interestingly, afobazole treatment down-regulated the mRNA expression of angiotensin, vasopressin, glucocorticoid receptor, and Epac2 protein level in the infarcted myocardium ( Kryzhanovskii et al, 2018 ). Another study also showed delayed cardioprotective effects of afobazole, evaluated by using echocardiography in an experim ental myocardial infarction model (rat model of acute myocardial ischemia) ( Kryzhanovskii et al, 2017 ). It has been proposed that the cardiotropic effects of the anxiolytic afobazole were associated with Sigmar1 agonistic effects in cardiomyocytes ( Kryzhanovskii et al, 2017 , 2018 ).…”

Section: Physiological and Pathological Role Of Sigmar1mentioning

confidence: 99%

See 1 more Smart Citation

Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology

et al. 2021

View full text Add to dashboard Cite

The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in Sigmar1 have been identified as a causative gene for neuronal and neuromuscular disorder. Since the discovery over 40 years ago, Sigmar1 has been shown to contribute to numerous cellular functions, including ion channel regulation, protein quality control, endoplasmic reticulum-mitochondrial communication, lipid metabolism, mitochondrial function, autophagy activation, and involved in cellular survival. Alterations in Sigmar1’s subcellular localization, expression, and signaling has been implicated in the progression of a wide range of diseases, such as neurodegenerative diseases, ischemic brain injury, cardiovascular diseases, diabetic retinopathy, cancer, and drug addiction. The goal of this review is to summarize the current knowledge of Sigmar1 biology focusing the recent discoveries on Sigmar1’s molecular, cellular, pathophysiological, and biological functions.

show abstract

Section: Myocardial Infarctionmentioning

confidence: 99%

Section: Physiological and Pathological Role Of Sigmar1mentioning

confidence: 99%

Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology

et al. 2021

View full text Add to dashboard Cite

show abstract

Role of Sigma-1 Receptors in the Regulation of Heart Function: II. Cardioprotective Role of Sigma-1 Receptors

2021

View full text Add to dashboard Cite

Assessment of ethylthiobenzimidazole and fabomotizole activity in a model of hypercapnic hypoxia with cutting off the brain hemispheres work

Marysheva

Mikheev

Shabanov

2022

Rev Clin Pharm Drug Ther

View full text Add to dashboard Cite

BACKGROUND: Resistance to hypoxia depends on the type of animal, its condition (fatigue, pre-exposure, pregnancy in females) and the conditions of the experiments. AIM: study the effect of ethylthiobenzimidazole (Metaprot, Bemityl) and fabomotizole (Afobazole), which were antihypoxants with an isothiourea group, on the resistance of male outbred mice to acute hypoxia with hypercapnia under conditions of isolated functioning of one of the cerebral hemispheres. MATERIALS AND METHODS: Acute hypoxia with hypercapnia was simulated by the cupping method by placing male mice in a closed hermetic volume (200 cm3) until the death of the animal. Previously, in some mice, one of the cerebral hemispheres was temporarily switched off according to the Leao method. RESULTS: It has been shown that ethylthiobenzimidazole and fabomotizole, administered intraperitoneally in equimolar doses (25 and 32.8 mg/kg, respectively) 30 min before a hypoxic episode, increase the life time of experimental animals when either of the hemispheres (right or left) is turned off approximately equally. CONCLUSIONS: Data are considered in terms of the possibility of using both drugs in the prevention and treatment of ischemic strokes.

show abstract

Delayed Results of Experimental Afobazole Therapy in Rats after Acute Myocardial Infarction

Cited by 3 publications

References 11 publications

Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology

Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology

Role of Sigma-1 Receptors in the Regulation of Heart Function: II. Cardioprotective Role of Sigma-1 Receptors

Assessment of ethylthiobenzimidazole and fabomotizole activity in a model of hypercapnic hypoxia with cutting off the brain hemispheres work

Contact Info

Product

Resources

About