Delayed response tasks and prefrontal lesions in man—Evidence for self generated patterns of behaviour with poor environmental modulation

Vérin, Marc; Partiot, Arnaud; Pillon, B.; Malapani, Chara; Agid, Yves; Dubois, Bruno

doi:10.1016/0028-3932(93)90105-9

Cited by 102 publications

(46 citation statements)

References 34 publications

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“…The importance of the frontal lobes for working memory functions on delay tasks had been demonstrated earlier in lesion-, imaging-and electrophysiological studies on humans and non-human primates (Fuster, 1984;Fuster, 1991;Goldman-Rakic, 1994;Rypma, Prabhakaran, Desmond, Glover, & Gabrieli, 1999;Ve erin et al, 1993;Wilson et al, 1993). The result of a non-specific degradation of working memory functions after frontal lobe lesion is compatible with recent studies indicating poor performance after frontal lobe lesions on temporal as well as on non-temporal tasks (Casini & Ivry, 1999;Mangels et al, 1998), especially when long ISIs were used.…”

Section: Recognition Taskssupporting

confidence: 80%

Processing of temporal duration information in working memory after frontodorsal tumour excisions

Hälbig

Cramon

Schmid

et al. 2002

Brain and Cognition

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This study aimed to test the hypothesis that impairments of temporal duration processing after frontal lobe lesions reflect deficits in executive monitoring functions rather than a domain-specific deficit in the maintenance of duration information in working memory. Patients with frontodorsal lesions, clinical controls with post-central lesions, and healthy controls performed recognition and classification tasks, which should allow for testing maintenance and monitoring functions, respectively. Results showed mild non-selective impairments of the frontal patients on both temporal and spatial recognition tasks, but a marked selective degradation on temporal classification while performance on spatial classification was unimpaired. This suggests that maintenance of duration information in working memory after frontal lesions is basically preserved but that, depending on executive task characteristics, there is a specific deficit in the strategic organization of this type of information.

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Section: Recognition Taskssupporting

confidence: 80%

Processing of temporal duration information in working memory after frontodorsal tumour excisions

Hälbig

Cramon

Schmid

et al. 2002

Brain and Cognition

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“…Certain neuropsychological deficits observed in patients with frontal lobe lesions have been interpreted in terms of working memory impairments (Freedman and Oscar-Berman, 1981;Verin, Partiot, Pillon et al, 1993). It could be argued that the present result can be explained by a general working memory deficit rather than being a specific impairment of action sequence processing.…”

Section: Discussionmentioning

confidence: 64%

Distinct Frontal Regions for Processing Sentence Syntax and Story Grammar

Sirigu

Cohen

Zalla

et al. 1998

Cortex

Self Cite

102

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Time is a fundamental dimension of cognition. It is expressed in the sequential ordering of individual elements in a wide variety of activities such as language, motor control or in the broader domain of long range goal-directed actions. Several studies have shown the importance of the frontal lobes in sequencing information. The question addressed in this study is whether this brain region hosts a single supramodal sequence processor, or whether separate mechanisms are required for different kinds of temporally organised knowledge structures such as syntax and action knowledge. Here we show that so-called agrammatic patients, with lesions in Broca's area, ordered word groups correctly to form a logical sequence of actions but they were severely impaired when similar word groups had to be ordered as a syntactically well-formed sentence. The opposite performance was observed in patients with dorsolateral prefrontal lesions, that is, while their syntactic processing was intact at the sentence level, they demonstrated a pronounced deficit in producing temporally coherent sequences of actions.Anatomical reconstruction of lesions from brain scans revealed that the sentence and action grammar deficits involved distinct, non-overlapping sites within the frontal lobes. Finally, in a third group of patients whose lesions encompassed both Broca's area and the prefrontal cortex, the two types of deficits were found. We conclude that sequence processing is specific to knowledge domains and involves different networks within the frontal lobes.

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“…Furthermore, in neuropsychological terms, dPFC injury or deactivation may impair recall equivalently on object, spatial, haptic, and cross-modal delayed-memory tasks, suggesting generality across stimulus domains (e.g., Bauer & Fuster, 1976;Fuster & Bauer, 1974;Quintana & Fuster, 1993;Verin et al, 1993). Moreover, PET results suggest equivalent dPFC activation in n-back tasks using visual versus auditory stimuli , and single-cell recordings indicate dPFC cells tuned to rule-dependent combinations of stimulus modalities (Fuster, Bodner, & Kroger, 2000;White & Wise, 1999).…”

Section: Discussionmentioning

confidence: 94%

The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: An individual-differences perspective

Kane

Engle

2002

Psychonomic Bulletin & Review

1,859

1,420

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Delayed response tasks and prefrontal lesions in man—Evidence for self generated patterns of behaviour with poor environmental modulation

Cited by 102 publications

References 34 publications

Processing of temporal duration information in working memory after frontodorsal tumour excisions

Processing of temporal duration information in working memory after frontodorsal tumour excisions

Distinct Frontal Regions for Processing Sentence Syntax and Story Grammar

The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: An individual-differences perspective

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