Delayed Repair: The Role of Glutathione in a Rat Incisional Wound Model

Adamson, Belinda; Schwarz, Daniel; Klugston, Patty; Gilmont, Robert R.; Perry, Larry; Fisher, Jack; Lindblad, William J.; Rees, Riley S.

doi:10.1006/jsre.1996.0189

Cited by 33 publications

(21 citation statements)

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“…These findings supports Ogle and co-workers suggesting that ME formulation prevents the degradation of peptides in gastrointestinal system [17]. It was reported that intracellular stores of GSH were sensitive to skin ischemia in rats and therefore, may regulate the early temporal course of wound healing [35]. Our results show decreased levels of GSH in duodenum tissue of untreated groups (AU, CU, PS groups) and increased duodenal levels of GSH in TGF-α treated groups ( Figure 3).…”

supporting

confidence: 91%

Effect of Oral TGF-Α Formulations on ASA Induced Duadenal Ulcer and The Role of Lipid Peroxidation in The Healing Process

Özer¹,

Gönül²,

Çelebi³

et al. 2012

Turk J Bioch

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supporting

confidence: 91%

Effect of Oral TGF-Α Formulations on ASA Induced Duadenal Ulcer and The Role of Lipid Peroxidation in The Healing Process

Özer¹,

Gönül²,

Çelebi³

et al. 2012

Turk J Bioch

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“…Depletion of GSH can inhibit lymphocyte activation and modulates the immune function [48,49] . Decreased GSH levels are also associated with attenuated signal transduction [50] .…”

Section: Discussionmentioning

confidence: 99%

Effect of Topical Application of Virgin Coconut Oil on Skin Components and Antioxidant Status during Dermal Wound Healing in Young Rats

Nevin

Rajamohan²

2010

Skin Pharmacol Physiol

123

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Objectives: The present study was undertaken to evaluate the effect of a topical application of virgin coconut oil (VCO) on excision wounds in young rats. Methods: Three sets of experiments with 3 groups of female Sprague-Dawley rats each consisting of 6 animals were used for studying wound closure time, antioxidant status and biochemical parameters. Group 1 was the control; groups 2 and 3 were treated with 0.5 and 1.0 ml VCO, respectively, 24 h after wound creation for 10 days. After the experimental period, the healing property of VCO was evaluated by monitoring the time taken for complete epithelization as well as levels of various parameters of the wound’s granulation tissue. The collagen solubility pattern, glycohydrolase activity, and histopathology of the granulation tissue were also analyzed. The antioxidant status during wound healing was monitored continuously for 14 days. Results: VCO-treated wounds healed much faster, as indicated by a decreased time of complete epithelization and higher levels of various skin components. Pepsin-soluble collagen showed a significant increase in VCO- treated wounds, indicating a higher collagen cross-linking. Glycohydrolase activities were also found to be increased due to a higher turnover of collagen. Antioxidant enzyme activities, and reduced glutathione and malondialdehyde levels were found to be increased on the 10th day after wounding, which were found to have returned to normal levels on day 14 in the treated wounds. The lipid peroxide levels were found to be lower in the treated wounds. A histopathological study showed an increase in fibroblast proliferation and neovascularization in VCO-treated wounds compared to controls. Conclusion: The beneficial effect of VCO can be attributed to the cumulative effect of various biologically active minor components present in it.

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“…Inflammatory and/or infectious events appearing immediately after surgery could induce a huge release of reactive types of oxygen at the corneal level; thus, creating a vicious circle in the degree of maintain themselves and to stimulate the sulfhydryls group in reacting and activation of radical oxidizers, underlining a possible role in the prevention of post-PRK complications and assisting normal corneal re-epithelization [42][43][44] .…”

Section: Discussionmentioning

confidence: 99%

Role of Cysteine in Corneal Wound Healing after Photorefractive Keratectomy

et al. 2008

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Aims: To evaluate the efficacy of cysteine oral supplements in corneal wound healing after photorefractive keratectomy (PRK). Methods: A total of 200 eyes (100 patients) underwent PRK. We divided patients into 2 groups; each group was composed of 50 patients (100 eyes). Group 1 patients were assigned to use oral L-cysteine, with a daily dose of 200 mg (100-mg pills to be taken twice a day) for a duration of 14 days, starting from the week preceding the operation; the patients in group 2 were used as a control, and received the oral supplementation of 40-mg placebo pills to be taken twice a day for a duration of 14 days, starting from the week preceding the operation. Results: All the eyes of patients treated with cysteine oral supplements showed shorter times to re-epithelization than the eyes of the control group. The mean time of corneal wound healing observed in group 1 was 102 ± 15 h, compared to an average of 159 ± 9 h in group 2. Conclusion: Our research showed that oral cysteine supplementation, in a daily dose of 200 mg, reduces mean corneal wound healing time in patients after PRK.

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Delayed Repair: The Role of Glutathione in a Rat Incisional Wound Model

Cited by 33 publications

References 1 publication

Effect of Oral TGF-Α Formulations on ASA Induced Duadenal Ulcer and The Role of Lipid Peroxidation in The Healing Process

Effect of Oral TGF-Α Formulations on ASA Induced Duadenal Ulcer and The Role of Lipid Peroxidation in The Healing Process

Effect of Topical Application of Virgin Coconut Oil on Skin Components and Antioxidant Status during Dermal Wound Healing in Young Rats

Role of Cysteine in Corneal Wound Healing after Photorefractive Keratectomy

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