Delayed Renal Graft Function: The Influence of Immunosuppression

Boletis, John; Balitsari, Anthi; Filiopoulos, V.; Stamataki, E.; Lionaki, Sophia; Zavos, G.; Kostakis, A.

doi:10.1016/j.transproceed.2005.03.052

Cited by 16 publications

(6 citation statements)

References 29 publications

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“…It is known that drugs used for immunosuppression may affect DGF and gene expression profile [11]. For example, it has been described that sirolimus prolongs recovery from delayed graft function after cadaveric renal transplantation [12].…”

Section: Discussionmentioning

confidence: 99%

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Gene Expression Profile in Delay Graft Function: Inflammatory Markers Are Associated with Recipient and Donor Risk Factors

Guerrieri

Petroni

et al. 2014

Mediators of Inflammation

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Background. Delayed graft function (DGF) remains an important problem after kidney transplantation and reduced long-term graft survival of the transplanted organ. The aim of the present study was to determine if the development of DGF was associated with a specific pattern of inflammatory gene expression in expanded criteria of deceased donor kidney transplantation. Also, we explored the presence of correlations between DGF risk factors and the profile that was found. Methods. Seven days after kidney transplant, a cDNA microarray was performed on biopsies of graft from patients with and without DGF. Data was confirmed by real-time PCR. Correlations were performed between inflammatory gene expression and clinical risk factors. Results. From a total of 84 genes analyzed, 58 genes were upregulated while only 1 gene was downregulated in patients with DGF compared with no DGF (P = 0.01). The most relevant genes fold changes observed was IFNA1, IL-10, IL-1F7, IL-1R1, HMOX-1, and TGF-β. The results were confirmed for IFNA1, IL-1R1, HMOX-1 and TGF-β. A correlation was observed between TGF-β, donor age, and preablation creatinine, but not body mass index (BMI). Also, TGF-β showed an association with recipient age, while IFNA1 correlated with recipient BMI. Furthermore, TGF-β, IFNA1 and HMOX-1 correlated with several posttransplant kidney function markers, such as diuresis, ultrasound Doppler, and glycemia. Conclusions. Overall, the present study shows that DGF is associated with inflammatory markers, which are correlated with donor and recipient DGF risk factors.

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Section: Discussionmentioning

confidence: 99%

“…In fact, there are much more factors that influence the DGF, such as immunosuppression therapy [11]. The relative impact of each of the markers on DGF is difficult to assess.…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profile in Delay Graft Function: Inflammatory Markers Are Associated with Recipient and Donor Risk Factors

Guerrieri

Petroni

et al. 2014

Mediators of Inflammation

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“…This complication is caused by a number of factors: donor type (deceased or live), warm and cold ischemia time, presence of special means for donor organ perfusion (for example, machine perfusion), induction and maintenance immunosupression regime, etc. (McTaggard et al, 2003;Sanchez-Fructuoso et al, 2004;Boletis et al, 2005;Lodhi et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Delayed Renal Graft Function in the Early Post-Transplant Period and its Impact on the Late Post-Transplant Results

Jušinskis¹,

Amerika²,

Maļcevs³

2013

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences

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Delayed renal graft function (DGF) is a frequent complication with negative impact on the course of early post-transplantation period. The data concerning the impact on the late results are contradictory. This study describes results of 5-year follow-up of 248 recipients after deceased donor renal transplantation. All patients were divided into two groups: with delayed graft function (DGF, n = 53) and immediate graft function, considered as the control group (IGF, n = 195). We evaluated factors that were associated with development of DGF and its impact on the survival of graft and recipient, and frequency of acute rejections and chronic dysfunctions. The rate of observed DGF was 21.4%. Its development was associated with the following factors: age of recipient and their weight, age of donor and their body mass index, high frequency of asystole/hypotension in donors prior to organ explantation (P < 0.05 for all), and longer time of cold ischemia (P = 0.058). The DGF group had higher rate of acute rejections (P < 0.001), and also lower 1.5 and 5-year graft survival and 1.5-year patient survival (P < 0.05 for all). The conclusion is that DGF has negative impact on the survival of renal grafts and patients, especially during the first 1.5 years after transplantation.

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“…Kidney IRI is of great importance occurring in various clinical settings including shock, vascular and cardiac surgery, sepsis, and kidney transplantation. During kidney transplantation, IRI causes delayed graft function (DGF) that has been associated with more frequent episodes of acute rejection and progression to chronic allograft nephropathy [ 2 – 4 ]. Complex interplay of pathophysiological processes linking inflammation, abnormal repair, and fibrosis makes AKI an important risk factor for progression of chronic kidney disease [ 5 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

Mitochondria‐Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury

Kezic

Spasojević

Ležaić

et al. 2016

Oxidative Medicine and Cellular Longevity

107

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Kidney ischemia/reperfusion injury emerges in various clinical settings as a great problem complicating the course and outcome. Ischemia/reperfusion injury is still an unsolved puzzle with a great diversity of investigational approaches, putting the focus on oxidative stress and mitochondria. Mitochondria are both sources and targets of ROS. They participate in initiation and progression of kidney ischemia/reperfusion injury linking oxidative stress, inflammation, and cell death. The dependence of kidney proximal tubule cells on oxidative mitochondrial metabolism makes them particularly prone to harmful effects of mitochondrial damage. The administration of antioxidants has been used as a way to prevent and treat kidney ischemia/reperfusion injury for a long time. Recently a new method based on mitochondria-targeted antioxidants has become the focus of interest. Here we review the current status of results achieved in numerous studies investigating these novel compounds in ischemia/reperfusion injury which specifically target mitochondria such as MitoQ, Szeto-Schiller (SS) peptides (Bendavia), SkQ1 and SkQR1, and superoxide dismutase mimics. Based on the favorable results obtained in the studies that have examined myocardial ischemia/reperfusion injury, ongoing clinical trials investigate the efficacy of some novel therapeutics in preventing myocardial infarct. This also implies future strategies in preventing kidney ischemia/reperfusion injury.

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Delayed Renal Graft Function: The Influence of Immunosuppression

Cited by 16 publications

References 29 publications

Gene Expression Profile in Delay Graft Function: Inflammatory Markers Are Associated with Recipient and Donor Risk Factors

Gene Expression Profile in Delay Graft Function: Inflammatory Markers Are Associated with Recipient and Donor Risk Factors

Delayed Renal Graft Function in the Early Post-Transplant Period and its Impact on the Late Post-Transplant Results

Mitochondria‐Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury

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