Delayed Renal Graft Function: The Influence of Immunosupression

A cutaneous disease with multisystem involvement: hypomelanosis of Ito may be associated with proteinuria, focal segmental glomerulosclerosis and end-stage renal disease

“…Hypomelanosis of Ito is a neuroectodermal disease frequently involving different organ systems [1,2]. Involvement of the kidneys has been reported very rarely [3].…”

“…Sir, Rapamycin-induced hypokalaemic nephropathy is rarely reported in renal transplant patients. Rapamycin, an mammalian target of rapamycin (MTOR) inhibitor, acts by preventing cell-cycle progression; it prolongs delayed graft function (DGF) and decreases repair of tubular cells [1]. There are reports of thrombotic microangiopathy when rapamycin is used with calcineurin inhibitors [2].…”

“…At the molecular level, MTOR is necessary for maintaining the integrity and regeneration of tubular epithelial cells, which account for the majority of potassium reabsorption [1]. The sustained improvement in creatinine and potassium following discontinuation of rapamycin strongly implicates this agent in the development of hypokalaemic nephropathy.…”