Delayed recovery and exaggerated infarct size by post-lesion stress in a rat model of focal cerebral stroke

Kirkland, Scott W.; Coma, Adrian K.; Colwell, Keri L.; Metz, Gerlinde A. S.

doi:10.1016/j.brainres.2008.01.032

Cited by 44 publications

(31 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present stress-induced alterations in skilled limb use resemble those described earlier [16,17,69]. Acute and chronic restraint stress led to reduction in reaching success along with an increase in number of attempts needed to grasp a pellet.…”

Section: Discussionsupporting

confidence: 80%

Sex differences in skilled movement in response to restraint stress and recovery from stress

Jadavji

Metz

2008

Behavioural Brain Research

Self Cite

View full text Add to dashboard Cite

Sex differences exist in skilled movement, and skilled motor performance is also influenced by stress. As shown for cognitive function, the effects of stress are usually characterized by considerable sexual dimorphism. The purpose of this study was to investigate sex differences in skilled motor function in response to stress. Male and female Long-Evans rats were trained and tested in skilled reaching and skilled walking tasks. Both groups of animals were then exposed to daily restraint stress for 15 days. Recovery from daily stress was assessed by comparing reaching performance at 10 min versus 60 min after restraint stress, and recovery from chronic stress was tested for 21 days after cessation of stress. Animals were tested daily in skilled reaching for the entire period. Observations showed that females performed significantly better than males during the stress period in terms of reaching success and number of attempts needed to grasp a food pellet. No difference between testing at 10 or 60 min after daily stress was found. Analysis of movement patterns and recovery from stress indicated that males and females use different strategies to overcome stress-induced motor disturbance. While male rats preferred to use original movement patterns, females tended to modify these patterns in order to increase reaching success. Modification of movement patterns in female rats was accompanied by a faster recovery in success rate after the cessation of stress. These results indicate sex differences in skilled reaching in response to stress, and in the recovery period after stress.

show abstract

Section: Discussionsupporting

confidence: 80%

Sex differences in skilled movement in response to restraint stress and recovery from stress

Jadavji

Metz

2008

Behavioural Brain Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Indeed, systemic administration of CORT or stress disturbs skilled and non-skilled movement at both acute and long-term intervals [19,20]. Moreover, motor function seems to be equally impaired by treatment with either stress or CORT [20,21,22,23]. These observations also apply to studies of brain damage.…”

Section: Introductionmentioning

confidence: 67%

“…For example, conditions such as Parkinson’s disease and stroke may become exaggerated by the experience of stress [21,22,24,81]. Blockade of MR and GR may represent a potential therapeutic target to facilitate symptomatic relief.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Blockade of Mineralocorticoid and Glucocorticoid Receptors Reverses Stress-Induced Motor Impairments

Jadavji

Supina²,

Metz³

2011

Neuroendocrinology

Self Cite

View full text Add to dashboard Cite

Aim: Stress and glucocorticoids can influence movement performance and pathologies of the motor system. The classic notion assumes that the glucocorticoid receptor (GR) mediates the majority of stress-induced behavioral changes. Nevertheless, recent findings have attributed a more prominent role to the mineralocorticoid receptor (MR) in modulating behavior. The purpose of this study was to dissociate the impact of MR versus GR activation in movement and stress-associated motor disruption. Methods: Groups of male and female rats were tested in skilled reaching and open field behavior and treated peri-orally with either agonists or antagonists for MR and GR, respectively. Results: Selective acute activation of MR (aldosterone) and GR (dexamethasone) decreased movement success with a magnitude similar to stress-induced impairment in male and female animals. By contrast, antagonist treatment to block MR (RU-28318) or GR (Mifepristone, RU-486) prevented motor impairments caused by acute restraint stress or corticosterone treatment. Moreover, both antagonists reversed chronic stress- and glucocorticoid-induced motor impairments to values comparable to baseline levels. Higher success rates in treated animals were accompanied by improved performance of skilled limb movements. In addition, combined treatment with MR and GR antagonists had additive benefit on aim and advance towards the reaching target. Conclusion: These observations suggest that MR or GR equally influence motor system function with partially synergistic effects. Males and females show comparable responses to MR and GR activation or blockade. The need for balanced activation of MRs and GRs in motor control requires consideration in intervention strategies to improve performance in health and disease.

show abstract

“…Sustained high levels of glucocorticoids may compromise the ability to overcome ischemia-induced deficits both on the neuronal and functional level [18][19][20][21][22]. Complex physiological changes involving activity of the HPA axis may explain, at least in part, the large variability of stroke recovery among aged individuals.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effects of age and stress in a rodent model of stroke

Merrett

Kirkland

Metz

2010

Behavioural Brain Research

Self Cite

View full text Add to dashboard Cite

Ageing and stress represent critical influences on stroke risk and outcome. These variables are intricately linked, as ageing is frequently associated with gradual dysregulation of the hypothalamic-pituitary-adrenal axis. This study determined the effects of stress on motor function in aged rats, and explored possible interactions of age and stress on motor recovery following stroke in a rat model. Young adult (4 months) and aged (18 months) male Wistar rats were tested in skilled and non-skilled movement before and after focal ischemia in motor cortex. One group of each age received restraint stress starting seven days pre-lesion until three weeks post-lesion. Aged rats were less mobile and stress further diminished their overall exploratory activity. Aged rats were also less proficient in motor skill acquisition and slower to improve after lesion. Stress diminished post-lesion improvement and prevented recovery of endpoint measures. The larger functional loss in aged rats vs. young rats was accompanied by greater damage of cortical tissue and persistent elevations in corticosterone levels. The behavioural and physiological measures suggest limited ability of aged animals to adapt to chronic stress. These findings show that age or stress alone can modulate motor performance but may have greater influence by synergistically affecting stroke recovery.

show abstract

Delayed recovery and exaggerated infarct size by post-lesion stress in a rat model of focal cerebral stroke

Cited by 44 publications

References 53 publications

Sex differences in skilled movement in response to restraint stress and recovery from stress

Sex differences in skilled movement in response to restraint stress and recovery from stress

Blockade of Mineralocorticoid and Glucocorticoid Receptors Reverses Stress-Induced Motor Impairments

Synergistic effects of age and stress in a rodent model of stroke

Contact Info

Product

Resources

About