Delayed reactions to urographic contrast media

Panto, Philip N.; Davies, Peter

doi:10.1259/0007-1285-59-697-41

Cited by 83 publications

(29 citation statements)

References 15 publications

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“…[36] Our reports observe that iodixanol contrast medium is associated with a lower frequency of late reaction compared to iohexol, but the difference was not statistically significant (p > 0.05). Three male patients had a late reaction, different from the female predominance in a previous report.…”

Section: Discussioncontrasting

confidence: 58%

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Comparison of Iodixanol and Iohexol in Patients Undergoing Intravenous Pyelography: A Prospective Controlled Study

et al. 2009

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182F.-R. Chuang et al.Background. Nephropathy associated with contrast medium exposure is a well-known complication of IVP. However, it is uncertain whether iso-osmolar non-iodinated contrast medium (iodixanol) is less nephrotoxic than low-osmolar contrast medium (iohexol). Materials and Methods. In this singlecenter, double-blind, prospective study, 50 patients undergoing IVP were randomized into two groups receiving different contrast medium: iodixanol and iohexol. Patients in high risk for contrast nephropathy were included, 28 with renal insufficiency and 19 with diabetes mellitus. We compared the nephrotoxic effect (contrast nephropathy), complement and cytokines profile between the iodixanol and iohexol groups. The mean volume of contrast medium in each IVP procedure was 0.8 mL/kg. Results. The incidence of contrast nephropathy was 4 percent among all patients (one iodixanol and one iohexol). We found no significant differences in contrast nephropathy and allergic reactions between the two groups. There was no significant difference in cytokine profiles in both groups (p > 0.05).The incidence of allergic reaction was 16 percent among all patients. Twelve percent (3/25) had late reaction after iohexol exposure compared to four percent (2/25) with iodixanol (p = 1.0). One patient had severe skin rash due to late adverse reaction after iodixanol. No mortality was found. Conclusions. New iodixanol and iohexol contrast medium for routine IVP examination are safe and have low nephrotoxicity profile, especially in elderly or high-risk patients. Iodixanol contrast medium has an increased risk to induce severe late adverse reaction compared to iohexol. Allergic reaction may be the main adverse effect after contrast medium infusion.

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Section: Discussioncontrasting

confidence: 58%

“…[30,31] Late reactions are reported with frequencies of between 8.7% and 70.0%, [34][35][36][37] and reports have also suggested that there is an increased frequency of late reaction with non-ionic dimeric CM compared to non-ionic monomeric CM. [31] The physiological background of late reaction is unknown.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Iodixanol and Iohexol in Patients Undergoing Intravenous Pyelography: A Prospective Controlled Study

et al. 2009

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“…Three of these (the hepatocyte sub-set, topical immune system and collagen support network) were taken as axioms for measuring the purely On the basis of our results, it is difficult not to consider biopsies a rich source of information regarding the course of chronic liver inflammation, despite their undeniable limitations [31] . Our perseverance in studying biopsies should be seen in the light of the risks [32][33][34][35][36] currently accepted in many fields of medical practice [37][38][39] (Table 7). Quantifying liver lesions in a biopsy sample raises many questions concerning the status and organization of natural and pathological liver systems that do not seem to be merely subsidiary matters to be dealt with within the confines of a specific investigation [1] .…”

Section: Table 5 Fibrosis Metrical and Semi-quantitative Case Numbersmentioning

confidence: 99%

Metrically measuring liver biopsy: A chronic hepatitis B and C computer-aided morphologic description

Dioguardi¹,

Grizzi²,

Fiamengo³

et al. 2008

WJG

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CONCLUSION:The results are the first standardized metrical evaluation of the geometric properties of the parenchyma, inflammation, fibrosis, and alterations in liver tissue tectonics of the biopsy sections. The present study confirms that biopsies are still valuable, not only for diagnosing chronic hepatitis, but also for quantifying changes in the organization and order of liver tissue structure. INTRODUCTIONThe main purpose of this paper is to describe a rigorous method based on the fundamentals of measurement theory [1] , which metrically defines the changes in magnitude of liver tissue prime basic structural elements that occurring during the course of chronic hepatitis B and C.Each available score to evaluate hepatic lesions is characterized by some methodological inaccuracy [2][3][4] . In fact, transient elastography (Fibro-Scan) [5,6] is limited by the skill of the operator and because liver stiffness is not only dependent from fibrosis, and serological assays not directly involved in tissue evolution, but in patient diagnosis [7][8][9][10][11] . In addition to the inherent risks of excising a liver specimen [12] , current morphometric analyses [13][14][15][16][17] are timeconsuming, depend on subjective choices of the regions of interest, involve the interactive elimination of Glisson's capsule and staining artefacts, and use the International System (IS), which is unsuitable for measuring the irregular shapes found in histology [18][19][20][21] . The study concerning the status of the liver tissue affected by chronic viral hepatitis was suggested by three Abstract AIM:To describe a quantitative analysis method for liver biopsy sections with a machine that we have named "Dioguardi Histological Metriser" which automatically measures the residual hepatocyte mass (including hepatocytes vacuolization), inflammation, fibrosis and the loss of liver tissue tectonics. METHODS: We analysed digitized images of liver biopsy sections taken from 398 patients. The analysis with Dioguardi Histological Metriser was validated by comparison with semi-quantitative scoring system. RESULTS: The method provides: (1) the metrical extension in two-dimensions (the plane) of the residual hepatocellular set, including the area of vacuoles pertinent to abnormal lipid accumulation; (2) the geometric measure of the inflammation basin, which distinguishes intra-basin space and extra-basin dispersed parenchymal leukocytes; (3) the magnitude of collagen islets, (which were considered truncated fractals and classified into three degrees of magnitude); and (4) the tectonic index that quantifies alterations (disorders) in the organization of liver tissue. Dioguardi Histological Metriser machine allows to work at a speed of 0.1 mm 2 /s, scanning a whole section in 6-8 min.

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“…These include hemody namic, chemotoxic, allergic and bactericidal effects. They are usually early but may be delayed [1][2][3][4],…”

Section: Introductionmentioning

confidence: 99%

“…How ever, the identification of antibodies to contrast media in patients with severe adverse reactions tends to contra dict this view [6], The chemotoxic effects are due to a variety of factors: haemodynamic and allergic responses as well as the toxic effects of iodine in large doses [4,7], The organs affected by the toxic effects are cardiovascu lar system [1,2,8], blood [9][10][11] and the salivary glands [4].…”

Section: Introductionmentioning

confidence: 99%

Gaseous Distension of the Gut during Intravenous Urography

Kolawole

Suhaibani²,

Patel³

et al. 1991

Urol Int

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During intravenous urography, the changes in the gastrointestinal tract were assessed in a total of 101 patients within two subgroups: allergic and non-allergic, depending on the patient’s reaction or non-reaction to the intravenously injected Conrary 420. The gastrointestinal changes were either nil (that is normal) or abnormal with definite increase in the total volume of gas in the abdomen. Increased gas was commoner (66%) among the non-allergic group as compared with 34% of the allergic group. The aetiological basis being postulated for this observation includes biochemical and chemical changes as well as allergic response within the gut.

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Delayed reactions to urographic contrast media

Cited by 83 publications

References 15 publications

Comparison of Iodixanol and Iohexol in Patients Undergoing Intravenous Pyelography: A Prospective Controlled Study

Comparison of Iodixanol and Iohexol in Patients Undergoing Intravenous Pyelography: A Prospective Controlled Study

Metrically measuring liver biopsy: A chronic hepatitis B and C computer-aided morphologic description

Gaseous Distension of the Gut during Intravenous Urography

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